2014
Reversible Modulation of Myofibroblast Differentiation in Adipose-Derived Mesenchymal Stem Cells
Desai VD, Hsia HC, Schwarzbauer JE. Reversible Modulation of Myofibroblast Differentiation in Adipose-Derived Mesenchymal Stem Cells. PLOS ONE 2014, 9: e86865. PMID: 24466271, PMCID: PMC3900664, DOI: 10.1371/journal.pone.0086865.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueBlotting, WesternCell DifferentiationCell MovementCells, CulturedExtracellular Matrix ProteinsFibroblast Growth Factor 2HumansMesenchymal Stem CellsMyofibroblastsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSignal TransductionConceptsAdipose-derived mesenchymal stem cellsMesenchymal stem cellsExtracellular matrixERK/MAP kinaseMyofibroblastic phenotypeStem cellsRegulation of tenascinProtein type IActivation of Smad2Abundant extracellular matrixFocal adhesionsGrowth factorKinase downstreamHuman adipose-derived mesenchymal stem cellsCytoskeletal proteinsMAP kinaseStress fibersECM proteinsCell differentiationADSC differentiationDifferentiation processFibroblast-like cellsMyofibroblast differentiationNovel therapeutic strategiesRegenerative medicine
2011
The Fiber Diameter of Synthetic Bioresorbable Extracellular Matrix Influences Human Fibroblast Morphology and Fibronectin Matrix Assembly
Hsia HC, Nair MR, Mintz RC, Corbett SA. The Fiber Diameter of Synthetic Bioresorbable Extracellular Matrix Influences Human Fibroblast Morphology and Fibronectin Matrix Assembly. Plastic & Reconstructive Surgery 2011, 127: 2312-2320. PMID: 21617465, PMCID: PMC3103705, DOI: 10.1097/prs.0b013e3182139fa4.Peer-Reviewed Original ResearchConceptsFibronectin matrix assemblyMatrix assemblyActin cytoskeletal morphologyFocal adhesion complexesFocal adhesion sizeActin stress fibersCell proliferationAdhesion complexesAdhesion sizeEnvironmental cuesStress fibersCellular responsesAbility of scaffoldsCytoskeletal morphologyScaffold fiber diameterHuman dermal fibroblastsFibril formationCell functionImmunofluorescent microscopyBiological responsesMicrofiber scaffoldsFibroblast morphologyDermal fibroblastsHigher cell proliferationCells
2006
Modulation of Cell–Fibronectin Matrix Interactions during Tissue Repair
Midwood KS, Mao Y, Hsia HC, Valenick LV, Schwarzbauer JE. Modulation of Cell–Fibronectin Matrix Interactions during Tissue Repair. Journal Of Investigative Dermatology Symposium Proceedings 2006, 11: 73-78. PMID: 17069013, DOI: 10.1038/sj.jidsymp.5650005.Peer-Reviewed Original ResearchConceptsFocal adhesion kinaseExtracellular matrixAlpha 4 beta 1Fibronectin matrixActin stress fibersECM protein tenascinAlpha v beta 3Cell surface receptorsFibrin-fibronectin matrixOrganization of fibronectinAlpha 5 beta 1 integrin receptorBeta 3 integrinActin cytoskeletonBeta 1 integrin receptorsEnvironmental signalsMotile phenotypeTransmembrane proteoglycansAdhesion kinaseRho GTPaseRho signalingWound provisional matrixBeta 1Stress fibersIntegrin functionMultiple intracellular