2019
Mouse Model of Pressure Ulcers After Spinal Cord Injury.
Kumar S, Tan Y, Yarmush ML, Dash BC, Hsia HC, Berthiaume F. Mouse Model of Pressure Ulcers After Spinal Cord Injury. Journal Of Visualized Experiments 2019 PMID: 30907872, DOI: 10.3791/58188.Peer-Reviewed Original ResearchConceptsSpinal cord injuryLevel of SCIPressure ulcersSCI miceCord injuryMouse modelComplete spinal cord injuryImpact of SCITraumatic spinal cord injuryComplete spinal cord transectionSpinal cord transectionAdult male miceRelevant mouse modelCord transectionIschemic areaMale miceTissue edemaPU developmentTherapeutic approachesAnimal modelsBony prominencesSuch woundsMiceSoft tissueHealing
2018
Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair
Shook BA, Wasko RR, Rivera-Gonzalez GC, Salazar-Gatzimas E, López-Giráldez F, Dash BC, Muñoz-Rojas AR, Aultman KD, Zwick RK, Lei V, Arbiser JL, Miller-Jensen K, Clark DA, Hsia HC, Horsley V. Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair. Science 2018, 362 PMID: 30467144, PMCID: PMC6684198, DOI: 10.1126/science.aar2971.Peer-Reviewed Original ResearchConceptsDifferential gene expressionAdipocyte precursorsExtracellular matrix moleculesGene expressionTransplantation assaysMatrix moleculesFactor C.Factor 1Insulin-like growth factor-1Cell populationsTissue resilienceDistinct subpopulationsGrowth factor-1Profibrotic cellsTissue repairMultiple mouse modelsECM depositionSkin repairTissue dysfunctionProliferationMouse modelMyofibroblastsWoundingMacrophagesRepairImpact of Complete Spinal Cord Injury on Healing of Skin Ulcers in Mouse Models
Kumar S, Yarmush ML, Dash BC, Hsia HC, Berthiaume F. Impact of Complete Spinal Cord Injury on Healing of Skin Ulcers in Mouse Models. Journal Of Neurotrauma 2018, 35: 815-824. PMID: 29160147, DOI: 10.1089/neu.2017.5405.Peer-Reviewed Original ResearchConceptsComplete spinal cord injurySpinal cord injuryPressure ulcersSCI miceSCI groupCord injuryMouse modelControl groupImpact of SCIExcisional woundsTraumatic spinal cord injuryAlpha-smooth muscle actinAdult male miceRelevant mouse modelLower blood vessel densitySuitable animal modelBlood vessel densityFull-thickness excisional woundsDynamics of skinBacks of miceIschemic areaMale miceTissue edemaSkin ulcersAnimal models