1994
Apical membrane Cl-butyrate exchange: Mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon
Rajendran V, Binder H. Apical membrane Cl-butyrate exchange: Mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon. The Journal Of Membrane Biology 1994, 141: 51-58. PMID: 7966245, DOI: 10.1007/bf00232873.Peer-Reviewed Original ResearchConceptsRat distal colonFatty acid stimulationDistal colonShort-chain fatty acidsNa-H exchangeActive chloride absorptionHalf maximal inhibitory concentrationAcid stimulationApical membrane vesiclesChain fatty acidsChloride absorptionFatty acid exchangeCl- gradientInhibitory concentrationOutward Cl gradientButyrate concentrationExtravesicular ClColonCellular modelMembrane vesiclesFatty acidsStimulationFunctional NaDisulfonic acidCompelling evidence
1989
Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon
Binder H, Mehta P. Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon. Gastroenterology 1989, 96: 989-996. PMID: 2925072, DOI: 10.1016/0016-5085(89)91614-4.Peer-Reviewed Original ResearchConceptsRat distal colonShort-chain fatty acidsCl absorptionDistal colonNa absorptionNet NaFatty acid stimulationNa-H exchangeHCO3- Ringer's solutionStimulation of NaColonic NaNet Cl- absorptionVoltage-clamp conditionsCarbonic anhydrase inhibitorsFatty acidsCoupling of NaMucosal amilorideChloride absorptionUnidirectional 22NaClamp conditionsButyrate stimulationStimulationColonActive sodiumAcid stimulation