1990
Aldosterone and glucocorticoid receptor-specific agonists regulate ion transport in rat proximal colon
Turnamian S, Binder H. Aldosterone and glucocorticoid receptor-specific agonists regulate ion transport in rat proximal colon. American Journal Of Physiology 1990, 258: g492-g498. PMID: 2138421, DOI: 10.1152/ajpgi.1990.258.3.g492.Peer-Reviewed Original ResearchConceptsDietary sodium depletionBody wt-1RU 28362Receptor-specific agonistsSodium depletionPotassium secretionProximal colonDay 1Glucocorticoid receptorWT-1Cl absorptionAdministration of spironolactoneActive potassium secretionRat proximal colonSecondary hyperaldosteronismContinuous infusionAldosteroneGlucocorticoid agonistAgonistsElectrolyte transportSecretionStimulationSignificant increaseInfusionColon
1988
Glucocorticoids have a different action than aldosterone on target tissue
Halevy J, Boulpaep E, Budinger M, Binder H, Hayslett J. Glucocorticoids have a different action than aldosterone on target tissue. American Journal Of Physiology 1988, 254: f153-f158. PMID: 3337244, DOI: 10.1152/ajprenal.1988.254.1.f153.Peer-Reviewed Original ResearchConceptsRU 28362Same doseInhibitory actionDexamethasone-treated animalsBody wt-1Effects of glucocorticoidsEffect of dexamethasoneReceptor-independent actionsRat distal colonSodium channel blockersMarked inhibitory actionEquivalent short-circuit currentBasolateral potential differenceAldosterone receptorsEpithelial changesDistal colonChannel blockersAldosteroneSynthetic glucocorticoidDay 1WT-1Large intestineGlucocorticoidsEpithelial resistanceMarked inhibition