2005
Cross-Sectional Relations of Peripheral Microvascular Function, Cardiovascular Disease Risk Factors, and Aortic Stiffness
Mitchell G, Vita J, Larson M, Parise H, Keyes M, Warner E, Vasan R, Levy D, Benjamin E. Cross-Sectional Relations of Peripheral Microvascular Function, Cardiovascular Disease Risk Factors, and Aortic Stiffness. Circulation 2005, 112: 3722-3728. PMID: 16330686, DOI: 10.1161/circulationaha.105.551168.Peer-Reviewed Original ResearchConceptsCarotid-femoral pulse wave velocityCardiovascular disease risk factorsDisease risk factorsBrachial pulse pressureMean arterial pressureAortic stiffnessAortic wall stiffnessRisk factorsArterial pressurePulse pressureBlood flowConventional cardiovascular disease risk factorsHyperemic forearm blood flowRisk factor-adjusted modelsFramingham Heart Study Offspring CohortAbnormal aortic stiffnessForearm blood flowBrachial artery diameterPeripheral microvascular functionForward pressure wave amplitudePulse wave velocitySmall artery structureHigh-resolution ultrasoundWall stiffnessMicrovascular reactivity
2004
Local Shear Stress and Brachial Artery Flow–Mediated Dilation
Mitchell G, Parise H, Vita J, Larson M, Warner E, Keaney J, Keyes M, Levy D, Vasan R, Benjamin E. Local Shear Stress and Brachial Artery Flow–Mediated Dilation. Hypertension 2004, 44: 134-139. PMID: 15249547, DOI: 10.1161/01.hyp.0000137305.77635.68.Peer-Reviewed Original ResearchConceptsHyperemic shear stressFlow-mediated dilationBrachial artery flow-mediated dilationArtery flow-mediated dilationRisk factorsPercent dilationBrachial arteryMultivariable analysisReactive hyperemiaEndothelium-dependent flow-mediated dilationCardiovascular disease risk factorsLipid medication useLocal endothelial dysfunctionStepwise multivariable analysisHormone replacement therapyMean arterial pressureDisease risk factorsBrachial artery flowPostischemic reactive hyperemiaBody mass indexSex-adjusted modelsFramingham Offspring StudyHigh-resolution ultrasoundArtery responsesEndothelial dysfunction