2024
Clinical Significance of Diffusion-Weighted Brain MRI Lesions After TAVR Results of a Patient-Level Pooled Analysis
Lansky A, Grubman D, Dwyer M, Zivadinov R, Parise H, Moses J, Shah T, Pietras C, Tirziu D, Gambone L, Leon M, Nazif T, Messé S. Clinical Significance of Diffusion-Weighted Brain MRI Lesions After TAVR Results of a Patient-Level Pooled Analysis. Journal Of The American College Of Cardiology 2024, 84: 712-722. PMID: 39142725, DOI: 10.1016/j.jacc.2024.05.055.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementClinical ischemic strokeAcute brain infarctionDW-MRIReceiver operating characteristicIschemic strokeTranscatheter aortic valve replacement resultBrain infarctionPatient-level pooled analysisC-statisticBrain MRI lesionsAcute ischemic brain injuryDiffusion-weighted magnetic resonance imagingAortic valve replacementIndividual lesion volumesCore laboratory analysisIschemic brain injuryPredicting ischemic strokeMagnetic resonance imagingStroke Prevention TrialMRI lesionsValve replacementDW-MRI acquisitionsPatient-level dataPooled analysis
2016
Simplified prediction of postoperative cardiac surgery outcomes with a novel score: R2CHADS2
Peguero J, Presti S, Issa O, Podesta C, Parise H, Layka A, Brenes J, Lamelas J, Lamas G. Simplified prediction of postoperative cardiac surgery outcomes with a novel score: R2CHADS2. American Heart Journal 2016, 177: 153-159. PMID: 27297861, DOI: 10.1016/j.ahj.2016.04.019.Peer-Reviewed Original ResearchConceptsR2CHADS2 scoresOperative mortalityPermanent strokePostoperative eventsRenal failureCoronary artery bypass graft surgeryArtery bypass graft surgeryThoracic Surgeons scoreBypass graft surgeryCHA2DS2-VASc scorePostoperative renal failurePredictor of morbidityCongestive heart failureCardiac surgery outcomesEnd-point variablesCHA2DS2-VAScPrior strokeGraft surgeryPostoperative outcomesValve surgerySurgeons scoreHeart failureSurgery outcomesCardiovascular surgeryInclusion criteria
2007
Pulse Pressure and Risk of New-Onset Atrial Fibrillation
Mitchell G, Vasan R, Keyes M, Parise H, Wang T, Larson M, D’Agostino R, Kannel W, Levy D, Benjamin E. Pulse Pressure and Risk of New-Onset Atrial Fibrillation. JAMA 2007, 297: 709-715. PMID: 17312290, DOI: 10.1001/jama.297.7.709.Peer-Reviewed Original ResearchConceptsIncident atrial fibrillationMean arterial pressureAtrial fibrillationPulse pressureRisk factorsArterial pressureCommunity-based observational cohortNew-onset atrial fibrillationIncidence of AFAF incidence ratesClinical risk factorsModifiable risk factorsVentricular fractional shorteningFramingham Heart Study participantsImportant risk factorCommunity-based sampleAtrial dimensionObservational cohortAortic stiffnessConsiderable morbidityFractional shorteningSystolic pressureAF riskDiastolic pressureVentricular mass
2005
Cross-Sectional Relations of Peripheral Microvascular Function, Cardiovascular Disease Risk Factors, and Aortic Stiffness
Mitchell G, Vita J, Larson M, Parise H, Keyes M, Warner E, Vasan R, Levy D, Benjamin E. Cross-Sectional Relations of Peripheral Microvascular Function, Cardiovascular Disease Risk Factors, and Aortic Stiffness. Circulation 2005, 112: 3722-3728. PMID: 16330686, DOI: 10.1161/circulationaha.105.551168.Peer-Reviewed Original ResearchConceptsCarotid-femoral pulse wave velocityCardiovascular disease risk factorsDisease risk factorsBrachial pulse pressureMean arterial pressureAortic stiffnessAortic wall stiffnessRisk factorsArterial pressurePulse pressureBlood flowConventional cardiovascular disease risk factorsHyperemic forearm blood flowRisk factor-adjusted modelsFramingham Heart Study Offspring CohortAbnormal aortic stiffnessForearm blood flowBrachial artery diameterPeripheral microvascular functionForward pressure wave amplitudePulse wave velocitySmall artery structureHigh-resolution ultrasoundWall stiffnessMicrovascular reactivityMetabolic Syndrome as a Precursor of Cardiovascular Disease and Type 2 Diabetes Mellitus
Wilson P, D’Agostino R, Parise H, Sullivan L, Meigs J. Metabolic Syndrome as a Precursor of Cardiovascular Disease and Type 2 Diabetes Mellitus. Circulation 2005, 112: 3066-3072. PMID: 16275870, DOI: 10.1161/circulationaha.105.539528.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseMetabolic syndromeCardiovascular diseaseRelative riskAge-adjusted relative riskType 2 diabetes mellitusPopulation attributable risk estimatesNew cardiovascular diseaseMetabolic syndrome traitsMiddle-aged adultsDiabetes mellitusIncident casesHeart diseaseNew T2DMT2DMType 2SyndromeEvent ratesRisk estimatesDiseaseSyndrome traitsMellitusWomenMenRisk
2004
Obesity and the Risk of New-Onset Atrial Fibrillation
Wang T, Parise H, Levy D, D’Agostino R, Wolf P, Vasan R, Benjamin E. Obesity and the Risk of New-Onset Atrial Fibrillation. JAMA 2004, 292: 2471-2477. PMID: 15562125, DOI: 10.1001/jama.292.20.2471.Peer-Reviewed Original ResearchConceptsBody mass indexNew-onset atrial fibrillationEchocardiographic left atrial diameterLeft atrial diameterAtrial fibrillationRisk factorsAtrial diameterBMI categoriesMass indexAF riskCommunity-based observational cohortNormal body mass indexAge-adjusted incidence ratesInterim myocardial infarctionCardiovascular risk factorsVentricular diastolic dysfunctionBaseline atrial fibrillationClinical risk factorsModifiable risk factorsInfluence of obesityDiastolic dysfunctionAtrial dilatationAtrial dimensionClinical confoundersHazard ratioLocal Shear Stress and Brachial Artery Flow–Mediated Dilation
Mitchell G, Parise H, Vita J, Larson M, Warner E, Keaney J, Keyes M, Levy D, Vasan R, Benjamin E. Local Shear Stress and Brachial Artery Flow–Mediated Dilation. Hypertension 2004, 44: 134-139. PMID: 15249547, DOI: 10.1161/01.hyp.0000137305.77635.68.Peer-Reviewed Original ResearchConceptsHyperemic shear stressFlow-mediated dilationBrachial artery flow-mediated dilationArtery flow-mediated dilationRisk factorsPercent dilationBrachial arteryMultivariable analysisReactive hyperemiaEndothelium-dependent flow-mediated dilationCardiovascular disease risk factorsLipid medication useLocal endothelial dysfunctionStepwise multivariable analysisHormone replacement therapyMean arterial pressureDisease risk factorsBrachial artery flowPostischemic reactive hyperemiaBody mass indexSex-adjusted modelsFramingham Offspring StudyHigh-resolution ultrasoundArtery responsesEndothelial dysfunctionMitral annular calcification is a predictor for incident atrial fibrillation
Fox C, Parise H, Vasan R, Levy D, O’Donnell C, D’Agostino R, Plehn J, Benjamin E. Mitral annular calcification is a predictor for incident atrial fibrillation. Atherosclerosis 2004, 173: 291-294. PMID: 15064104, DOI: 10.1016/j.atherosclerosis.2003.12.018.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedAged, 80 and overAtrial FibrillationCalcinosisCohort StudiesComorbidityEchocardiography, DopplerElectrocardiographyFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedMitral Valve StenosisProbabilityProportional Hazards ModelsRetrospective StudiesRisk AssessmentSeverity of Illness IndexSex DistributionConceptsMitral annular calcificationIncident atrial fibrillationAtrial fibrillationAnnular calcificationAdverse cardiovascular disease outcomesSex-adjusted incidence ratesRisk of AFLeft atrial sizeMultivariable-adjusted analysesCardiac valvular calcificationCardiovascular disease outcomesCommunity-based cohortM-mode echocardiographyProportional hazards modelLong-term riskFramingham Heart StudyIncident AFHazard ratioAtrial enlargementAtrial sizeEchocardiographic assessmentValvular calcificationOriginal cohortProspective dataIncidence rate
2003
Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study
Roubenoff R, Parise H, Payette H, Abad L, D'Agostino R, Jacques P, Wilson P, Dinarello C, Harris T. Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study. The American Journal Of Medicine 2003, 115: 429-435. PMID: 14563498, DOI: 10.1016/j.amjmed.2003.05.001.Peer-Reviewed Original ResearchConceptsIGF-1 levelsInsulin-like growth factor-1Growth factor-1Fat-free massFramingham Heart StudyMass indexInterleukin-6TNF-alphaHeart StudyHigh serum interleukin-6 levelsHigher serum IGF-1 levelsBlood mononuclear cell productionOlder community-dwelling menSerum IGF-1 levelsSerum interleukin-6 levelsCommunity-dwelling older personsFat-free mass indexCommunity-dwelling elderly adultsSerum interleukin-6Interleukin-6 levelsCommunity-dwelling menMononuclear cell productionBody mass indexCytokines TNF-alphaFactor 1