2005
Response: Flow-Mediated Dilation: Just a Marker of Local Shear Stress?
Mitchell G, Warner E, Parise H, Vita J, Keaney J, Keyes M, Levy D, Larson M, Vasan R, Benjamin E. Response: Flow-Mediated Dilation: Just a Marker of Local Shear Stress? Hypertension 2005, 45: e11-e12. PMID: 15642771, DOI: 10.1161/01.hyp.0000154362.35209.b9.Peer-Reviewed Original Research
2004
Local Shear Stress and Brachial Artery Flow–Mediated Dilation
Mitchell G, Parise H, Vita J, Larson M, Warner E, Keaney J, Keyes M, Levy D, Vasan R, Benjamin E. Local Shear Stress and Brachial Artery Flow–Mediated Dilation. Hypertension 2004, 44: 134-139. PMID: 15249547, DOI: 10.1161/01.hyp.0000137305.77635.68.Peer-Reviewed Original ResearchConceptsHyperemic shear stressFlow-mediated dilationBrachial artery flow-mediated dilationArtery flow-mediated dilationRisk factorsPercent dilationBrachial arteryMultivariable analysisReactive hyperemiaEndothelium-dependent flow-mediated dilationCardiovascular disease risk factorsLipid medication useLocal endothelial dysfunctionStepwise multivariable analysisHormone replacement therapyMean arterial pressureDisease risk factorsBrachial artery flowPostischemic reactive hyperemiaBody mass indexSex-adjusted modelsFramingham Offspring StudyHigh-resolution ultrasoundArtery responsesEndothelial dysfunctionChanges in Arterial Stiffness and Wave Reflection With Advancing Age in Healthy Men and Women
Mitchell G, Parise H, Benjamin E, Larson M, Keyes M, Vita J, Vasan R, Levy D. Changes in Arterial Stiffness and Wave Reflection With Advancing Age in Healthy Men and Women. Hypertension 2004, 43: 1239-1245. PMID: 15123572, DOI: 10.1161/01.hyp.0000128420.01881.aa.Peer-Reviewed Original ResearchConceptsPulse wave velocityCarotid-femoral pulse wave velocityArterial stiffness gradientArterial stiffnessPulse pressureHigher carotid-femoral pulse wave velocityElevated central pulse pressureHigher mean arterial pressureCardiovascular disease risk factorsPeripheral pulse wave velocityFramingham Heart Study Offspring CohortClinical cardiovascular diseaseMean arterial pressurePeripheral arterial stiffnessCentral pulse pressureDisease risk factorsMultivariable linear regression modelsAge 50 yearsAge-related increaseArterial tonometryAortic stiffnessArterial pressureAugmentation indexHealthy menUnfavorable prognosis