Alcohol-mediated renal denervation in patients with hypertension in the absence of antihypertensive medications.
Pathak A, Rudolph U, Saxena M, Zeller T, Müller-Ehmsen J, Lipsic E, Schmieder R, Sievert H, Halbach M, Sharif F, Parise H, Fischell T, Weber M, Kandzari D, Mahfoud F. Alcohol-mediated renal denervation in patients with hypertension in the absence of antihypertensive medications. EuroIntervention 2023, 19: 602-611. PMID: 37427416, PMCID: PMC10493775, DOI: 10.4244/eij-d-23-00088.Peer-Reviewed Original ResearchConceptsSystolic blood pressureRenal denervationBlood pressureAntihypertensive medicationsRDN groupMedication burdenMean office blood pressureOffice systolic blood pressureSystolic BP 140Office blood pressurePrimary efficacy endpointMajor adverse eventsSystolic BP changeDiastolic blood pressureLower blood pressureRadiofrequency renal denervationLower medication burdenSignificant BP differencesMedication escalationEfficacy endpointSafety endpointAdverse eventsSham groupBP changesMedication washout