2014
Chapter Six The Role of Guanfacine as a Therapeutic Agent to Address Stress-Related Pathophysiology in Cocaine-Dependent Individuals
Fox H, Sinha R. Chapter Six The Role of Guanfacine as a Therapeutic Agent to Address Stress-Related Pathophysiology in Cocaine-Dependent Individuals. Advances In Pharmacology 2014, 69: 217-265. PMID: 24484979, PMCID: PMC4017947, DOI: 10.1016/b978-0-12-420118-7.00006-8.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsAdaptive goal-directed behaviorNegative emotional statesGoal-directed behaviorCompulsive drug useDrug-seeking behaviorCocaine dependenceStress-related pathophysiologyCognitive regulationNegative affectEmotional controlEmotional statesAnxiety pathophysiologyPrefrontal cortexDrugs of abuseNeural systemsBehavioral processesRecent research findingsBrain regionsCocaine addictionGuanfacinePolydrug abusersResearch findingsCocaine withdrawal symptomsDrug use
2012
Stress system changes associated with marijuana dependence may increase craving for alcohol and cocaine
Fox HC, Tuit KL, Sinha R. Stress system changes associated with marijuana dependence may increase craving for alcohol and cocaine. Human Psychopharmacology Clinical And Experimental 2012, 28: 40-53. PMID: 23280514, PMCID: PMC3660143, DOI: 10.1002/hup.2280.Peer-Reviewed Original ResearchConceptsAlcohol cravingCue-related cravingTreatment-seeking individualsStress-induced cortisolMeasures of cravingCue-induced anxietyMarijuana relapseMotivational processesImagery conditionAnxiety ratingsDrugs of abuseMarijuana dependenceEarly abstinenceCravingCocaine cravingMarijuana abuseAnxietyLittle researchCardiovascular outputRecovery time pointsCuesDependent groupInpatient treatmentAbuseHealthy controls