Varicella-Zoster Virus Infection of Human Fibroblast Cells Activates the c-Jun N-Terminal Kinase Pathway
Zapata HJ, Nakatsugawa M, Moffat JF. Varicella-Zoster Virus Infection of Human Fibroblast Cells Activates the c-Jun N-Terminal Kinase Pathway. Journal Of Virology 2006, 81: 977-990. PMID: 17079291, PMCID: PMC1797429, DOI: 10.1128/jvi.01470-06.Peer-Reviewed Original ResearchMeSH KeywordsCell LineEnzyme ActivationFibroblastsHerpesvirus 3, HumanHumansJNK Mitogen-Activated Protein KinasesMAP Kinase Kinase 4MAP Kinase Kinase 7Proto-Oncogene Proteins c-junVirionConceptsPhospho-c-JunC-JunPhospho-JNKKinase pathwayC-Jun N-terminal kinaseC-Jun N-terminal kinase (JNK) pathwayTranscription factor ATF-2N-terminal kinase pathwayProtein kinase pathwayImmunofluorescent confocal microscopyN-terminal kinaseBiochemical fractionationKinase assaysUseful drug targetC-Jun levelsATF-2Phosphorylated formVirus genesJNK pathwayDrug targetsHuman fibroblast cellsPhosphorylated JNKJNKMain activatorHuman foreskin fibroblasts