2020
Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults
Avey S, Mohanty S, Chawla DG, Meng H, Bandaranayake T, Ueda I, Zapata HJ, Park K, Blevins TP, Tsang S, Belshe RB, Kaech SM, Shaw AC, Kleinstein SH. Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults. The Journal Of Immunology 2020, 204: 1661-1673. PMID: 32060136, PMCID: PMC7755271, DOI: 10.4049/jimmunol.1900922.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAgingAntibodies, ViralCohort StudiesFemaleGene Expression ProfilingHemagglutination Inhibition TestsHumansImmunogenicity, VaccineInfluenza A virusInfluenza VaccinesInfluenza, HumanMaleNK Cell Lectin-Like Receptor Subfamily BOligonucleotide Array Sequence AnalysisSeasonsTranscriptomeVaccinationVaccines, InactivatedYoung AdultConceptsVaccine-induced Ab responsesOlder adultsInfluenza vaccinationDays postvaccinationInfluenza vaccineAb responsesMore effective influenza vaccinesImportant public health toolInactivated influenza vaccinationSeasonal influenza vaccineVaccine-induced immunityEffective influenza vaccinesMolecular signaturesEffects of immunosenescencePublic health toolImmune signaturesVaccination seasonVaccine responsesVaccine compositionSubset of individualsAge groupsHealth toolsSingle age groupAdultsPostvaccination
2015
The Microbiota and Microbiome in Aging: Potential Implications in Health and Age‐Related Diseases
Zapata HJ, Quagliarello VJ. The Microbiota and Microbiome in Aging: Potential Implications in Health and Age‐Related Diseases. Journal Of The American Geriatrics Society 2015, 63: 776-781. PMID: 25851728, PMCID: PMC4406803, DOI: 10.1111/jgs.13310.Peer-Reviewed Original ResearchConceptsOlder adultsClostridium difficile colitisDevelopment of comorbiditiesCommensal bacterial communityDifficile colitisVulvovaginal atrophyProinflammatory stateAtherosclerotic diseaseClinical changesColorectal carcinomaPhysical frailtyClinical problemLocation of residenceGut microbiotaDeoxyribonucleic acid sequencingHealthy adultsAccompany agingBasal levelsAdultsMicrobiotaDiseaseMicrobiomeColitisComorbiditiesPotential implications