2023
Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome
Morand-Beaulieu S, Crowley M, Grantz H, Leckman J, Sukhodolsky D. Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome. Psychological Medicine 2023, 53: 7857-7864. PMID: 37485677, PMCID: PMC10755221, DOI: 10.1017/s0033291723001940.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBehavior TherapyChildHumansSeverity of Illness IndexTic DisordersTicsTourette SyndromeConceptsVoluntary tic suppressionTic suppressionVocal tic severityFunctional connectivityTic severityTourette syndromeRight superior frontal gyrusFirst-line treatmentBehavior therapyComprehensive Behavioral InterventionSuperior frontal gyrusRight angular gyrusVocal ticsFunctional brain networksBehavioral interventionsUsual control conditionFrontal gyrusBaselineAngular gyrusSeverityBrain networksSyndromeChildrenTherapyGyrus
2021
Increased Alpha-Band Connectivity During Tic Suppression in Children With Tourette Syndrome Revealed by Source Electroencephalography Analyses
Morand-Beaulieu S, Wu J, Mayes LC, Grantz H, Leckman JF, Crowley MJ, Sukhodolsky DG. Increased Alpha-Band Connectivity During Tic Suppression in Children With Tourette Syndrome Revealed by Source Electroencephalography Analyses. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2021, 8: 241-250. PMID: 33991741, PMCID: PMC8589865, DOI: 10.1016/j.bpsc.2021.05.001.Peer-Reviewed Original ResearchConceptsTourette syndromeTic suppressionNetwork-based statisticsDefault mode networkCortical regionsRight superior frontal gyrusMode networkAge-mediated increaseFuture treatment studiesSuperior frontal gyrusAlpha-band connectivityChronic motorHigh-density electroencephalographyPhonic ticsLeft precuneusCortical areasBrain regionsTreatment studiesBrain circuitsFunctional connectivityBrain connectivityFrontal gyrusGraph theoretical analysisNeurodevelopmental disordersBrain correlates
2019
Discrepancies between parent and child ratings of anxiety in children with autism spectrum disorder
Kalvin CB, Marsh CL, Ibrahim K, Gladstone TR, Woodward D, Grantz H, Ventola P, Sukhodolsky DG. Discrepancies between parent and child ratings of anxiety in children with autism spectrum disorder. Autism Research 2019, 13: 93-103. PMID: 31643143, PMCID: PMC7062240, DOI: 10.1002/aur.2220.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxiety DisordersAutism Spectrum DisorderChildFemaleHumansMaleParentsSelf Report
2014
Individualized Assessments in Treatment Research: An Examination of Parent-Nominated Target Problems in the Treatment of Disruptive Behaviors in Youth with Tourette Syndrome
McGuire JF, Sukhodolsky DG, Bearss K, Grantz H, Pachler M, Lombroso PJ, Scahill L. Individualized Assessments in Treatment Research: An Examination of Parent-Nominated Target Problems in the Treatment of Disruptive Behaviors in Youth with Tourette Syndrome. Child Psychiatry & Human Development 2014, 45: 686-694. PMID: 24477478, DOI: 10.1007/s10578-014-0437-7.Peer-Reviewed Original Research
2012
Tourette syndrome in youth with and without obsessive compulsive disorder and attention deficit hyperactivity disorder
Lebowitz ER, Motlagh MG, Katsovich L, King RA, Lombroso PJ, Grantz H, Lin H, Bentley MJ, Gilbert DL, Singer HS, Coffey BJ, the Tourette Syndrome Study Group, Kurlan RM, Leckman JF. Tourette syndrome in youth with and without obsessive compulsive disorder and attention deficit hyperactivity disorder. European Child & Adolescent Psychiatry 2012, 21: 451-457. PMID: 22543961, PMCID: PMC3722559, DOI: 10.1007/s00787-012-0278-5.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderComorbid tic disordersObsessive-compulsive disorderSeverity of ticsChronic tic disorderTic disordersPsychosocial stressDeficit hyperactivity disorderGlobal functioningComorbid diagnosesHyperactivity disorderMore severe ticsComorbid attention deficit hyperactivity disorderDiagnosis of OCDComorbid obsessive-compulsive disorderAdditional comorbid diagnosesSymptoms of anxietyHigh psychosocial stressMore internalizing disordersGreater psychosocial stressSevere ticsOppositional defiant disorderSevere subtypeTic severityTourette syndrome
2010
Streptococcal Upper Respiratory Tract Infections and Exacerbations of Tic and Obsessive-Compulsive Symptoms: A Prospective Longitudinal Study
Leckman JF, King RA, Gilbert DL, Coffey BJ, Singer HS, Dure LS, Grantz H, Katsovich L, Lin H, Lombroso PJ, Kawikova I, Johnson DR, Kurlan RM, Kaplan EL. Streptococcal Upper Respiratory Tract Infections and Exacerbations of Tic and Obsessive-Compulsive Symptoms: A Prospective Longitudinal Study. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 50: 108-118.e3. PMID: 21241948, PMCID: PMC3024577, DOI: 10.1016/j.jaac.2010.10.011.Peer-Reviewed Original ResearchConceptsExacerbation of ticsGABHS infectionStreptococcal infectionSymptom exacerbationStreptococcal upper respiratory tract infectionPediatric autoimmune neuropsychiatric disordersUpper respiratory tract infectionObsessive-compulsive symptomsAutoimmune neuropsychiatric disordersHemolytic streptococcal infectionRespiratory tract infectionsThroat swab cultureLongitudinal studyProspective longitudinal studyPANDAS subjectsClinical exacerbationStreptococcal antibodiesTract infectionsClinical symptomsGABHS infectionsGroup of childrenLaboratory valuesSwab culturesClinical conditionsClinical evaluators
2009
Streptococcal Upper Respiratory Tract Infections and Psychosocial Stress Predict Future Tic and Obsessive-Compulsive Symptom Severity in Children and Adolescents with Tourette Syndrome and Obsessive-Compulsive Disorder
Lin H, Williams KA, Katsovich L, Findley DB, Grantz H, Lombroso PJ, King RA, Bessen DE, Johnson D, Kaplan EL, Landeros-Weisenberger A, Zhang H, Leckman JF. Streptococcal Upper Respiratory Tract Infections and Psychosocial Stress Predict Future Tic and Obsessive-Compulsive Symptom Severity in Children and Adolescents with Tourette Syndrome and Obsessive-Compulsive Disorder. Biological Psychiatry 2009, 67: 684-691. PMID: 19833320, PMCID: PMC2843763, DOI: 10.1016/j.biopsych.2009.08.020.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-Bacterial AgentsAttention Deficit Disorder with HyperactivityChildDepressive DisorderFemaleForecastingHumansLife Change EventsMaleObsessive-Compulsive DisorderPredictive Value of TestsProspective StudiesPsychologyRespiratory Tract InfectionsSeverity of Illness IndexStreptococcal InfectionsTicsTourette SyndromeConceptsDepressive symptom severityObsessive-compulsive disorderGABHS infectionPsychosocial stressTourette syndromeSymptom severityControl subjectsStreptococcal upper respiratory tract infectionUpper respiratory tract infectionBeta-hemolytic streptococcal infectionCurrent psychosocial stressRespiratory tract infectionsHealthy control subjectsProspective longitudinal studyEarly-onset obsessive-compulsive disorderMinority of childrenOC symptom severityTract infectionsStreptococcal infectionGABHS infectionsObsessive-compulsive symptom severityClinical ratingsNew infectionsClinical ratersControl status
2007
Repetitive Transcranial Magnetic Stimulation of the Supplementary Motor Area in the treatment of Tourette Syndrome: Report of two cases
Mantovani A, Leckman JF, Grantz H, King RA, Sporn AL, Lisanby SH. Repetitive Transcranial Magnetic Stimulation of the Supplementary Motor Area in the treatment of Tourette Syndrome: Report of two cases. Clinical Neurophysiology 2007, 118: 2314-2315. PMID: 17709291, DOI: 10.1016/j.clinph.2007.07.011.Peer-Reviewed Original Research
2006
Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive‐compulsive disorder
Lin H, Katsovich L, Ghebremichael M, Findley DB, Grantz H, Lombroso PJ, King RA, Zhang H, Leckman JF. Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive‐compulsive disorder. Journal Of Child Psychology And Psychiatry 2006, 48: 157-166. PMID: 17300554, PMCID: PMC3073143, DOI: 10.1111/j.1469-7610.2006.01687.x.Peer-Reviewed Original ResearchConceptsDepressive symptom severityFuture depressive symptomsHealthy control subjectsObsessive-compulsive disorderDepressive symptomsPsychosocial stressTourette syndromeSymptom severityControl subjectsLong-term contextual threatSeverity of ticsProspective longitudinal studyChronological ageIndependent predictorsOC symptomsTic severityOC symptom severityPsychosocial adversitySymptomsFuture symptom severityClinician ratingsSeverityParental reportsSignificant predictorsLongitudinal study
2005
Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome
Leckman JF, Katsovich L, Kawikova I, Lin H, Zhang H, Krönig H, Morshed S, Parveen S, Grantz H, Lombroso PJ, King RA. Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome. Biological Psychiatry 2005, 57: 667-673. PMID: 15780855, DOI: 10.1016/j.biopsych.2004.12.004.Peer-Reviewed Original ResearchConceptsEarly-onset obsessive-compulsive disorderObsessive-compulsive disorderSymptom exacerbationInterleukin-12Control subjectsImmune responseTourette syndromeTumor necrosis factor-alpha concentrationsNecrosis factor-alpha concentrationsAge-matched control subjectsInvolvement of innateLocal cytokine synthesisT cell immunityHumoral immune responseCentral nervous systemInnate immune responseLongitudinal studyProspective longitudinal studyT cell activationCell immunitySerum levelsPediatric populationCommon infectionsSerum concentrationsInflammatory process
2004
Prospective Longitudinal Study of Children With Tic Disorders and/or Obsessive-Compulsive Disorder: Relationship of Symptom Exacerbations to Newly Acquired Streptococcal Infections
Luo F, Leckman JF, Katsovich L, Findley D, Grantz H, Tucker DM, Lombroso PJ, King RA, Bessen DE. Prospective Longitudinal Study of Children With Tic Disorders and/or Obsessive-Compulsive Disorder: Relationship of Symptom Exacerbations to Newly Acquired Streptococcal Infections. Pediatrics 2004, 113: e578-e585. PMID: 15173540, DOI: 10.1542/peds.113.6.e578.Peer-Reviewed Original ResearchConceptsGABHS infectionSymptom exacerbationObsessive-compulsive disorderControl subjectsTourette syndromeAcute exacerbationTime pointsHealthy control subjectsBeta-hemolytic streptococciAcute inflammatory responseAcute symptom exacerbationsProspective longitudinal studyAutoimmune mechanismsPediatric patientsStreptococcal infectionNeuropsychiatric symptomsGABHS infectionsNonspecific markerInflammatory responseTic disordersUnselected groupObsessive-compulsive symptom severityExacerbationPatientsObsessive-compulsive symptoms
2003
Development of the Yale Children’s Global Stress Index (YCGSI) and Its Application in Children and Adolescents With Tourette’s Syndrome and Obsessive-Compulsive Disorder
FINDLEY DB, LECKMAN JF, KATSOVICH L, LIN H, ZHANG H, GRANTZ H, OTKA J, LOMBROSO PJ, KING RA. Development of the Yale Children’s Global Stress Index (YCGSI) and Its Application in Children and Adolescents With Tourette’s Syndrome and Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2003, 42: 450-457. PMID: 12649632, DOI: 10.1097/01.chi.0000046816.95464.ef.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTourette syndromeDaily Life Stressors ScalePsychosocial stressAge-matched control subjectsClinician ratingsClinical rating instrumentGlobal clinician ratingsTime pointsGlobal Stress IndexCross-sectional ratingsEarly-onset obsessive-compulsive disorderPsychometric propertiesControl subjectsClinical severityObsessive-compulsive symptom severityStudy of childrenAcceptable psychometric propertiesStress indexSymptom severitySyndromePossible differential contributionInterrater reliabilityStressor ScaleDisorders
2002
Assessment of Symptom Exacerbations in a Longitudinal Study of Children With Tourette's Syndrome or Obsessive-Compulsive Disorder
LIN H, YEH CB, PETERSON BS, SCAHILL L, GRANTZ H, FINDLEY DB, KATSOVICH L, OTKA J, LOMBROSO PJ, KING RA, LECKMAN JF. Assessment of Symptom Exacerbations in a Longitudinal Study of Children With Tourette's Syndrome or Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2002, 41: 1070-1077. PMID: 12218428, DOI: 10.1097/00004583-200209000-00007.Peer-Reviewed Original Research