Diurnal effects of polypharmacy with high drug burden index on physical activities over 23 h differ with age and sex
Tran T, Mach J, Gemikonakli G, Wu H, Allore H, Howlett SE, Little CB, Hilmer SN. Diurnal effects of polypharmacy with high drug burden index on physical activities over 23 h differ with age and sex. Scientific Reports 2022, 12: 2168. PMID: 35140291, PMCID: PMC8828819, DOI: 10.1038/s41598-022-06039-4.Peer-Reviewed Original ResearchConceptsHigher Drug Burden IndexDrug Burden IndexBurden indexYoung miceOld micePhysical activityDifferent drug regimensWeeks of treatmentDrug-induced deliriumDaily physical activityTreatment × sex interactionBehavioral changesConsideration of ageSex-specific effectsSimvastatin monotherapyDrug regimensGait speedFunctional impairmentGlobal healthcare challengePolypharmacyQuality useOlder ageBehavioral declineMiceOlder adults