2023
Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19
Liu Y, Rajeevan H, Simonov M, Lee S, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Ortega H, Zaeh S, Gomez J, Cohn L, Gautam S, Chupp G. Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3383-3390.e3. PMID: 37454926, PMCID: PMC10787810, DOI: 10.1016/j.jaip.2023.07.006.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseType 2 inflammationCOVID-19 severitySOFA scoreAirway diseaseNoneosinophilic asthmaSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreSevere coronavirus disease 2019Higher SOFA scoreMedian SOFA scoreRetrospective cohort studyObstructive pulmonary diseaseOdds of mortalityLower SOFA scoresCells/μLCOVID-19 outcomesCoronavirus disease 2019Logistic regression analysisCOVID-19Clinical confoundersAsthma patientsCohort studyImmunological factorsClinical featuresDeep learning prediction of hospital readmissions for asthma and COPD
Lopez K, Li H, Lipkin-Moore Z, Kay S, Rajeevan H, Davis J, Wilson F, Rochester C, Gomez J. Deep learning prediction of hospital readmissions for asthma and COPD. Respiratory Research 2023, 24: 311. PMID: 38093373, PMCID: PMC10720134, DOI: 10.1186/s12931-023-02628-7.Peer-Reviewed Original Research
2022
User centered clinical decision support to implement initiation of buprenorphine for opioid use disorder in the emergency department: EMBED pragmatic cluster randomized controlled trial
Melnick ER, Nath B, Dziura JD, Casey MF, Jeffery MM, Paek H, Soares WE, Hoppe JA, Rajeevan H, Li F, Skains RM, Walter LA, Patel MD, Chari SV, Platts-Mills TF, Hess EP, D'Onofrio G. User centered clinical decision support to implement initiation of buprenorphine for opioid use disorder in the emergency department: EMBED pragmatic cluster randomized controlled trial. The BMJ 2022, 377: e069271. PMID: 35760423, PMCID: PMC9231533, DOI: 10.1136/bmj-2021-069271.Peer-Reviewed Original ResearchConceptsOpioid use disorderUsual care armEmergency departmentUse disordersCare armPragmatic clusterClinical decision supportIntervention armRoutine emergency careSecondary implementation outcomesSeverity of withdrawalTertiary care centerClinical decision support toolInitiation of buprenorphineElectronic health record tasksElectronic health record workflowsRE-AIM frameworkElectronic health record platformsHealth record platformsClinical decision support systemElectronic health recordsVisit documentationTreatment of addictionUsual careAdult patientsIf you personalize it, will they use it?: Self-reported and observed use of a tailored, internet-based pain self-management program
Reuman L, Solar C, MacLean RR, Halat AM, Rajeevan H, Williams DA, Heapy AA, Bair MJ, Krein SL, Kerns RD, Higgins DM. If you personalize it, will they use it?: Self-reported and observed use of a tailored, internet-based pain self-management program. Translational Behavioral Medicine 2022, 12: 693-701. PMID: 35192703, PMCID: PMC9154266, DOI: 10.1093/tbm/ibab165.Peer-Reviewed Original Research
2021
A fast likelihood approach for estimation of large phylogenies from continuous trait data
Peng J, Rajeevan H, Kubatko L, RoyChoudhury A. A fast likelihood approach for estimation of large phylogenies from continuous trait data. Molecular Phylogenetics And Evolution 2021, 161: 107142. PMID: 33713799, DOI: 10.1016/j.ympev.2021.107142.Peer-Reviewed Original ResearchConceptsContinuous trait dataMaximum likelihood estimatorMaximum likelihood estimatesMathematical propertiesHundreds of taxaInternal branch lengthsFast approximationAddition of taxaLarge-scale genomic dataCollection of methodsBayesian frameworkLikelihood estimatorLikelihood estimatesLikelihood approachMaximum likelihoodIntensive calculationsModel-based methodApproximationLarge phylogeniesComparable accuracyPossible phylogenyInferenceBranch lengthsEstimatorSuch data
2020
Predictors of engagement in an internet-based cognitive behavioral therapy program for veterans with chronic low back pain
Solar C, Halat AM, MacLean RR, Rajeevan H, Williams DA, Krein SL, Heapy AA, Bair MJ, Kerns RD, Higgins DM. Predictors of engagement in an internet-based cognitive behavioral therapy program for veterans with chronic low back pain. Translational Behavioral Medicine 2020, 11: 1274-1282. PMID: 33098304, DOI: 10.1093/tbm/ibaa098.Peer-Reviewed Original ResearchConceptsChronic low back painLow back painClinical characteristicsBack painChronic painEASE programParticipant characteristicsInternet-based cognitive behavioural therapy programmeInternet-based cognitive behavioral therapy interventionInternet-based interventionsCognitive behavioral therapy interventionInternet-based programCognitive behavioral therapy programBehavioral therapy interventionBehavioral therapy programRace/ethnicityPain careMean ageNumber of loginsIncreased ageTherapy interventionWeek trialPainTherapy programPredictors of engagementA Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries
Bhasin S, Gill TM, Reuben DB, Latham NK, Ganz DA, Greene EJ, Dziura J, Basaria S, Gurwitz JH, Dykes PC, McMahon S, Storer TW, Gazarian P, Miller ME, Travison TG, Esserman D, Carnie MB, Goehring L, Fagan M, Greenspan SL, Alexander N, Wiggins J, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace RB, Casteel C, Resnick NM, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Meng C, Allore H, Brawley BF, Eder R, McGloin JM, Skokos EA, Duncan PW, Baker D, Boult C, Correa-de-Araujo R, Peduzzi P. A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries. New England Journal Of Medicine 2020, 383: 129-140. PMID: 32640131, PMCID: PMC7421468, DOI: 10.1056/nejmoa2002183.Peer-Reviewed Original ResearchConceptsSerious fall injuriesFall injuriesIntervention groupControl groupUsual careMultifactorial interventionRate of hospitalizationPrimary care practicesCluster-randomized trialCommunity-dwelling adultsFirst-event analysisYears of ageHealth care systemRate of fallElectronic health recordsBaseline characteristicsPrimary outcomeRandomized trialsMean ageEfficacy trialsIndividualized planCare practicesInjuryMultifactorial strategyEvent ratesInterrupted Time Series of User‐centered Clinical Decision Support Implementation for Emergency Department–initiated Buprenorphine for Opioid Use Disorder
Holland WC, Nath B, Li F, Maciejewski K, Paek H, Dziura J, Rajeevan H, Lu CC, Katsovich L, D'Onofrio G, Melnick ER. Interrupted Time Series of User‐centered Clinical Decision Support Implementation for Emergency Department–initiated Buprenorphine for Opioid Use Disorder. Academic Emergency Medicine 2020, 27: 753-763. PMID: 32352206, PMCID: PMC7496559, DOI: 10.1111/acem.14002.Peer-Reviewed Original ResearchConceptsOpioid use disorderComputerized clinical decision support systemsRates of EDBUP initiationUse disordersClinical decision support implementationEmergency department initiationRoutine emergency careInterrupted time series studyAdult ED patientsInterrupted time seriesClinical decision support systemElectronic health recordsClinicians' unfamiliarityED initiationDecision support implementationED dischargeOpioid withdrawalSecondary outcomesOngoing trialsPrimary outcomeAcademic EDED patientsSingle EDUnique patientsInternet‐Based Pain Self‐Management for Veterans: Feasibility and Preliminary Efficacy of the Pain EASE Program
Higgins DM, Buta E, Williams DA, Halat A, Bair MJ, Heapy AA, Krein SL, Rajeevan H, Rosen MI, Kerns RD. Internet‐Based Pain Self‐Management for Veterans: Feasibility and Preliminary Efficacy of the Pain EASE Program. Pain Practice 2020, 20: 357-370. PMID: 31778281, DOI: 10.1111/papr.12861.Peer-Reviewed Original ResearchConceptsChronic low back painSelf-management programPain interferencePreliminary efficacyInternet-based self-management programPhase IPost-baseline assessmentLow back painPain Self-ManagementPhase IIPreliminary efficacy studyTechnology-delivered interventionsModerate painSecondary outcomesPain intensityBack painAverage ageEfficacy studiesDepression symptomsSubject improvementExpert panelSelf-ManagementSubject changesEASE programWeeksFrogAncestryCalc: A standalone batch likelihood computation tool for ancestry inference panels catalogued in FROG-kb
Rajeevan H, Soundararajan U, Pakstis AJ, Kidd KK. FrogAncestryCalc: A standalone batch likelihood computation tool for ancestry inference panels catalogued in FROG-kb. Forensic Science International Genetics 2020, 46: 102237. PMID: 31991337, DOI: 10.1016/j.fsigen.2020.102237.Peer-Reviewed Original Research
2019
Population relationships based on 170 ancestry SNPs from the combined Kidd and Seldin panels
Pakstis AJ, Speed WC, Soundararajan U, Rajeevan H, Kidd JR, Li H, Kidd KK. Population relationships based on 170 ancestry SNPs from the combined Kidd and Seldin panels. Scientific Reports 2019, 9: 18874. PMID: 31827153, PMCID: PMC6906462, DOI: 10.1038/s41598-019-55175-x.Peer-Reviewed Original ResearchConceptsGenetic diversityPopulation relationshipsHuman populationAncestry informative SNP panelsInformative SNP panelsMajor continental regionsHuman reference populationsSNP panelIndividual populationsGenotype dataReference populationNative American populationsDiverse collectionAISNPsAllele frequency databasesWorldwide populationDiversityFrequency databaseAmerican populationReference population dataPopulationSNPsPrincipal component analysisCombined panelCluster patternsGenetic relationships of European, Mediterranean, and SW Asian populations using a panel of 55 AISNPs
Pakstis AJ, Gurkan C, Dogan M, Balkaya HE, Dogan S, Neophytou PI, Cherni L, Boussetta S, Khodjet-El-Khil H, Ben Ammar ElGaaied A, Salvo NM, Janssen K, Olsen GH, Hadi S, Almohammed EK, Pereira V, Truelsen DM, Bulbul O, Soundararajan U, Rajeevan H, Kidd JR, Kidd KK. Genetic relationships of European, Mediterranean, and SW Asian populations using a panel of 55 AISNPs. European Journal Of Human Genetics 2019, 27: 1885-1893. PMID: 31285530, PMCID: PMC6871633, DOI: 10.1038/s41431-019-0466-6.Peer-Reviewed Original Research
2018
Improving ancestry distinctions among Southwest Asian populations
Bulbul O, Speed WC, Gurkan C, Soundararajan U, Rajeevan H, Pakstis AJ, Kidd KK. Improving ancestry distinctions among Southwest Asian populations. Forensic Science International Genetics 2018, 35: 14-20. PMID: 29625264, DOI: 10.1016/j.fsigen.2018.03.010.Peer-Reviewed Original Research
2017
The redesigned Forensic Research/Reference on Genetics-knowledge base, FROG-kb
Kidd KK, Soundararajan U, Rajeevan H, Pakstis AJ, Moore KN, Ropero-Miller JD. The redesigned Forensic Research/Reference on Genetics-knowledge base, FROG-kb. Forensic Science International Genetics 2017, 33: 33-37. PMID: 29175726, DOI: 10.1016/j.fsigen.2017.11.009.Peer-Reviewed Original ResearchConceptsWeb interfaceFROG-kbAccessible web interfaceDatabase interfaceEasy navigationNew reference panelsWeb sitesGenetic knowledge baseIndividual identification single nucleotide polymorphismsExtensive redesignExtensive documentationOngoing updatesComprehensive toolInterfaceOngoing researchForensicsNavigationIndividual identification SNPsFunctional enhancementReference population dataPrototypeDocumentationIncreasing the reference populations for the 55 AISNP panel: the need and benefits
Pakstis AJ, Kang L, Liu L, Zhang Z, Jin T, Grigorenko EL, Wendt FR, Budowle B, Hadi S, Al Qahtani MS, Morling N, Mogensen HS, Themudo GE, Soundararajan U, Rajeevan H, Kidd JR, Kidd KK. Increasing the reference populations for the 55 AISNP panel: the need and benefits. International Journal Of Legal Medicine 2017, 131: 913-917. PMID: 28070634, PMCID: PMC5491587, DOI: 10.1007/s00414-016-1524-z.Peer-Reviewed Original Research
2016
Evaluating a subset of ancestry informative SNPs for discriminating among Southwest Asian and circum-Mediterranean populations
Bulbul O, Cherni L, Khodjet-el-khil H, Rajeevan H, Kidd KK. Evaluating a subset of ancestry informative SNPs for discriminating among Southwest Asian and circum-Mediterranean populations. Forensic Science International Genetics 2016, 23: 153-158. PMID: 27160361, DOI: 10.1016/j.fsigen.2016.04.010.Peer-Reviewed Original Research
2015
52 additional reference population samples for the 55 AISNP panel
Pakstis AJ, Haigh E, Cherni L, ElGaaied AB, Barton A, Evsanaa B, Togtokh A, Brissenden J, Roscoe J, Bulbul O, Filoglu G, Gurkan C, Meiklejohn KA, Robertson JM, Li CX, Wei YL, Li H, Soundararajan U, Rajeevan H, Kidd JR, Kidd KK. 52 additional reference population samples for the 55 AISNP panel. Forensic Science International Genetics 2015, 19: 269-271. PMID: 26355664, DOI: 10.1016/j.fsigen.2015.08.003.Peer-Reviewed Original Research
2014
Application of six IrisPlex SNPs and comparison of two eye color prediction systems in diverse Eurasia populations
Yun L, Gu Y, Rajeevan H, Kidd KK. Application of six IrisPlex SNPs and comparison of two eye color prediction systems in diverse Eurasia populations. International Journal Of Legal Medicine 2014, 128: 447-453. PMID: 24395150, DOI: 10.1007/s00414-013-0953-1.Peer-Reviewed Original Research
2011
ALFRED: an allele frequency resource for research and teaching
Rajeevan H, Soundararajan U, Kidd JR, Pakstis AJ, Kidd KK. ALFRED: an allele frequency resource for research and teaching. Nucleic Acids Research 2011, 40: d1010-d1015. PMID: 22039151, PMCID: PMC3245092, DOI: 10.1093/nar/gkr924.Peer-Reviewed Original Research
2009
The phenotype and genotype experiment object model (PaGE‐OM): a robust data structure for information related to DNA variation
Brookes AJ, Lehvaslaiho H, Muilu J, Shigemoto Y, Oroguchi T, Tomiki T, Mukaiyama A, Konagaya A, Kojima T, Inoue I, Kuroda M, Mizushima H, Thorisson GA, Dash D, Rajeevan H, Darlison MW, Woon M, Fredman D, Smith AV, Senger M, Naito K, Sugawara H. The phenotype and genotype experiment object model (PaGE‐OM): a robust data structure for information related to DNA variation. Human Mutation 2009, 30: 968-977. PMID: 19479963, DOI: 10.1002/humu.20973.Peer-Reviewed Original Research