2008
Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the ovarian cancer association consortium pooled analysis
Pearce CL, Wu AH, Gayther SA, Bale AE, Beck P, Beesley J, Chanock S, Cramer D, DiCioccio R, Edwards R, Fredericksen Z, Garcia-Closas M, Goode E, Green A, Hartmann L, Hogdall E, Kjær S, Lissowska J, McGuire V, Modugno F, Moysich K, Ness R, Ramus S, Risch H, Sellers T, Song H, Stram D, Terry K, Webb P, Whiteman D, Whittemore A, Zheng W, Pharoah P, Chenevix-Trench G, Pike M, Schildkraut J, Berchuck A, on behalf of the Ovarian Cancer Association Consortium (OCAC). Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the ovarian cancer association consortium pooled analysis. British Journal Of Cancer 2008, 98: 282-288. PMID: 18219286, PMCID: PMC2361465, DOI: 10.1038/sj.bjc.6604170.Peer-Reviewed Original ResearchConceptsEndometrioid ovarian cancerOvarian cancer riskProgesterone receptor geneCase-control studyOvarian cancerCancer riskSingle nucleotide polymorphismsPGR single-nucleotide polymorphismInvasive epithelial ovarian cancerOvarian cancer case-control studiesEpithelial ovarian cancerUnconditional logistic regressionCancer case-control studyOvarian cancer casesOvarian Cancer Association ConsortiumTwo-sided p valueEndometrioid subtypePROGINS alleleCancer casesBorderline evidencePROGINS variantSubtype analysisSignificant associationT variantCancer
2006
PGR +331 A/G and Increased Risk of Epithelial Ovarian Cancer
Risch HA, Bale AE, Beck PA, Zheng W. PGR +331 A/G and Increased Risk of Epithelial Ovarian Cancer. Cancer Epidemiology Biomarkers & Prevention 2006, 15: 1738-1741. PMID: 16985038, DOI: 10.1158/1055-9965.epi-06-0272.Peer-Reviewed Original ResearchConceptsOvarian cancerA allelePostmenopausal womenProgesterone receptor gene polymorphismHistologic tumor typePopulation-based studyEpithelial ovarian cancerEffect of progesteroneReceptor gene polymorphismsPremenopausal womenEndometrial cancerMenopausal statusOral contraceptivesOvarian neoplasiaProgesterone receptorProgestin exposureG genotypeGG genotypeGene polymorphismsTumor typesReceptor isoformsCancerWomenRiskProgesterone
2001
Progesterone receptor variant increases ovarian cancer risk in BRCA1 and BRCA2 mutation carriers who were never exposed to oral contraceptives
Runnebaum I, Wang-Gohrke S, Vesprini D, Kreienberg R, Lynch H, Moslehi R, Ghadirian P, Weber B, Godwin A, Risch H, Garber J, Lerman C, Olopade O, Foulkes W, Karlan B, Warner E, Rosen B, Rebbeck T, Tonin P, Dubé M, Kieback D, Narod S. Progesterone receptor variant increases ovarian cancer risk in BRCA1 and BRCA2 mutation carriers who were never exposed to oral contraceptives. Pharmacogenetics And Genomics 2001, 11: 635-638. PMID: 11668223, DOI: 10.1097/00008571-200110000-00010.Peer-Reviewed Original ResearchConceptsPROGINS alleleOvarian cancerOral contraceptivesBRCA2 mutationsCarriers of BRCA1Oral contraceptive useOvarian cancer riskHereditary ovarian cancerBRCA2 mutation carriersOral contraception useForms of cancerYear of birthPrior diagnosisBRCA2 carriersProgesterone receptorBreast cancerMutation carriersContraceptive useCancer riskContraception useHereditary breastDisease statusPast exposureCancerBRCA1 mutations
1997
Breast Cancer Risk Factors According to Combined Estrogen and Progesterone Receptor Status: A Case-Control Analysis
Yoo K, Tajima K, Miura S, Takeuchi T, Hirose K, Risch H, Dubrow R. Breast Cancer Risk Factors According to Combined Estrogen and Progesterone Receptor Status: A Case-Control Analysis. American Journal Of Epidemiology 1997, 146: 307-314. PMID: 9270409, DOI: 10.1093/oxfordjournals.aje.a009271.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBreast NeoplasmsCase-Control StudiesFemaleHumansLogistic ModelsMiddle AgedOdds RatioReceptors, EstrogenReceptors, ProgesteroneReproductive HistoryRisk FactorsConceptsProgesterone receptor statusHormone receptor statusReceptor statusEstrogen receptor statusRisk factorsBreast cancerAichi Cancer Center HospitalBreast cancer risk factorsDiagnosis/interviewReproductive risk factorsCancer Center HospitalCancer risk factorsGradient of riskBreast cancer casesCase-control analysisPolytomous logistic regressionCancer-free controlsCommon control groupStratification of casesJoint estrogenCenter HospitalMenstrual regularityCigarette smokingCombined EstrogenProgesterone receptor
1993
A hospital-based case-control study of breast-cancer risk factors by estrogen and progesterone receptor status
Yoo K, Tajima K, Miura S, Yoshida M, Murai H, Kuroishi T, Lee Y, Risch H, Dubrow R. A hospital-based case-control study of breast-cancer risk factors by estrogen and progesterone receptor status. Cancer Causes & Control 1993, 4: 39-44. PMID: 8431529, DOI: 10.1007/bf00051712.Peer-Reviewed Original ResearchMeSH KeywordsAdultBreast NeoplasmsCase-Control StudiesFemaleHumansJapanMiddle AgedReceptors, EstrogenReceptors, ProgesteroneRisk FactorsConceptsHospital-based case-control studyBreast cancer risk factorsProgesterone receptor statusCase-control studyEstrogen receptorRisk factorsBreast cancerPR statusReceptor statusPR-negative breast cancerER-negative breast cancerFull-term pregnancyPR-negative casesBreast cancer casesCancer-free controlsSignificant differencesER statusMenstrual regularityEtiologic distinctionsBorderline differenceNegative casesCancerStatusAgePercent