2009
Polymorphic Variation of Genes in the Fibrinolytic System and the Risk of Ovarian Cancer
Bentov Y, Brown TJ, Akbari MR, Royer R, Risch H, Rosen B, McLaughlin J, Sun P, Zhang S, Narod SA, Casper RF. Polymorphic Variation of Genes in the Fibrinolytic System and the Risk of Ovarian Cancer. PLOS ONE 2009, 4: e5918. PMID: 19526059, PMCID: PMC2691597, DOI: 10.1371/journal.pone.0005918.Peer-Reviewed Original ResearchConceptsOvarian cancerSingle nucleotide polymorphismsCandidate genesFibrinolytic systemGenesFunctional variantsFunctional SNPsNucleotide polymorphismsPolymorphic variationBlood clot degradationOvarian cancer casesFunctional effectsSNPsHistologic subgroupsRetrograde menstruationCancer casesClot degradationGenotype distributionBlood clotsSignificant associationCancerFibrin productsGermlineInefficient removalRisk
2007
GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas
Wideroff L, Vaughan TL, Farin FM, Gammon MD, Risch H, Stanford JL, Chow WH. GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas. Cancer Epidemiology 2007, 31: 233-236. PMID: 17646057, PMCID: PMC2268246, DOI: 10.1016/j.cdp.2007.03.004.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAllelesArylamine N-AcetyltransferaseCase-Control StudiesCytochrome P-450 CYP1A1Esophageal NeoplasmsFemaleGenetic Predisposition to DiseaseGlutathione S-Transferase piGlutathione TransferaseHumansIsoenzymesMaleMiddle AgedOdds RatioPolymerase Chain ReactionPolymorphism, GeneticRisk FactorsStomach NeoplasmsUnited StatesConceptsGastric adenocarcinomaOdds ratioGastric cardia adenocarcinomaEsophageal adenocarcinomaCardia adenocarcinomaElevated riskConfidence intervalsVal genotypePopulation-based case-control studyCYP1A1 Val/ValGSTP1 Val/Val genotypeNoncardia gastric adenocarcinomaEpidemiologic risk factorsRespective odds ratiosRisk of esophagealIle/Val genotypeVal/Val genotypeCase-control studyVal/ValN-acetyltransferase 1Same catchment areaHistologic subgroupsIncident casesRisk factorsGSTT1 genotype