2022
Sex differences in early and term placenta are conserved in adult tissues
Olney K, Plaisier S, Phung T, Silasi M, Perley L, O’Bryan J, Ramirez L, Kliman H, Wilson M. Sex differences in early and term placenta are conserved in adult tissues. Biology Of Sex Differences 2022, 13: 74. PMID: 36550527, PMCID: PMC9773522, DOI: 10.1186/s13293-022-00470-y.Peer-Reviewed Original ResearchConceptsFirst trimester placentaLate first trimesterTerm placentaTrimester placentaFirst trimesterAdult tissuesGene expressionSex differencesLifelong health outcomesSex-differential gene expressionGenetic sexInnate immune responseFull-term placentaSex-linked genesInnate immune genesImmune responsePlacenta samplesHealth outcomesBrain tissuePlacentaGametologous genesDifferent timepointsSex chromosomesImmune genesSexInsulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity
Anam AK, Cooke KM, Dratver MB, O'Bryan JV, Perley LE, Guller SM, Hwang JJ, Taylor HS, Goedeke L, Kliman HJ, Vatner DF, Flannery CA. Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity. Molecular Metabolism 2022, 64: 101574. PMID: 35970449, PMCID: PMC9440306, DOI: 10.1016/j.molmet.2022.101574.Peer-Reviewed Original ResearchConceptsDe novo lipogenesisFetal adiposityFatty acid uptakeMaternal obesityObese womenNormal weightExcess adiposityVillous explantsInsulin receptorNewborns of mothersNormal-weight womenAcid uptakePlacental villous explantsTranscription factor SREBP-1Insulin-like growth factor 2Effect of insulinFatty acid oxidationPlacental triglyceridesPlacental responsesElevated triglyceridesMaternal hyperglycemiaWeight womenGrowth factor 2Diabetes riskPlacental metabolism
2021
Genetics, not the uterine environment, drive the formation of trophoblast inclusions: Insights from a twin study
Katz J, Holzer PH, Kliman HJ. Genetics, not the uterine environment, drive the formation of trophoblast inclusions: Insights from a twin study. Placenta 2021, 114: 133-138. PMID: 33941390, DOI: 10.1016/j.placenta.2021.04.010.Peer-Reviewed Original ResearchConceptsMean differenceUterine environmentTwin pairsTrophoblast inclusionsRetrospective case seriesCase seriesPregnancy lossIntrauterine environmentFetal geneticsMZ twinsDZ twinsDizygotic twin pairsMZ twin pairsGenetic abnormalitiesPlacentaZygosity groupsTwin individualsAverage numberMonozygoticTwin studiesMean absolute differenceAbsolute differenceDifferencesGroupFetuses
2019
An experimental test of the ovulatory homolog model of female orgasm
Pavlicev M, Zupan AM, Barry A, Walters S, Milano KM, Kliman HJ, Wagner GP. An experimental test of the ovulatory homolog model of female orgasm. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 20267-20273. PMID: 31570579, PMCID: PMC6789565, DOI: 10.1073/pnas.1910295116.Peer-Reviewed Original ResearchConceptsCopulation-induced ovulationOvulation rateEffects of fluoxetineHuman chorionic gonadotropinNeuro-endocrine mechanismsFluoxetine treatmentDaily dosesSerotonin functionChorionic gonadotropinSingle injectionPharmacological agentsFluoxetineFemale orgasmOvulationOrgasmRabbitsAnimalsGonadotropinDosesAdult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy
Tal R, Shaikh S, Pallavi P, Tal A, López-Giráldez F, Lyu F, Fang YY, Chinchanikar S, Liu Y, Kliman HJ, Alderman M, Pluchino N, Kayani J, Mamillapalli R, Krause DS, Taylor HS. Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy. PLOS Biology 2019, 17: e3000421. PMID: 31513564, PMCID: PMC6742226, DOI: 10.1371/journal.pbio.3000421.Peer-Reviewed Original ResearchConceptsBM transplantsDecidual cellsPregnancy lossMesenchymal stem cellsAdult bone marrow progenitorsDecidualization-related genesBone marrow progenitorsAdult bone marrowWT donorsPhysiologic contributionSuccessful pregnancyBMDC recruitmentStromal expansionImmune cellsEndometrial cellsDeficient miceUterine expressionUterine tissueDecidual stromaPregnancyBone marrowNonhematopoietic cellsBMDCsHemochorial placentaMarrow progenitors
2018
hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia
Mackie DI, Al Mutairi F, Davis RB, Kechele DO, Nielsen NR, Snyder JC, Caron MG, Kliman HJ, Berg JS, Simms J, Poyner DR, Caron KM. hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia. Journal Of Experimental Medicine 2018, 215: 2339-2353. PMID: 30115739, PMCID: PMC6122977, DOI: 10.1084/jem.20180528.Peer-Reviewed Original ResearchConceptsStructure-function insightsG protein-coupled receptorsNovel candidate genesFirst extracellular loopProtein-coupled receptorsReceptor activity modifying proteinMutant resultsPlasma membraneCandidate genesGenetic mouse modelsExtracellular loopFrame deletionBiochemical assaysGenetic ablationReceptor chaperoneLymphatic endothelialModifying proteinsCalcitonin receptor-like receptorHuman physiologyEmbryonic demiseChaperonesMouse modelLymphatic dysplasiaReceptorsGenesType I interferons instigate fetal demise after Zika virus infection
Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y, Horvath TL, Weatherbee S, Kliman HJ, Coyne CB, Iwasaki A. Type I interferons instigate fetal demise after Zika virus infection. Science Immunology 2018, 3 PMID: 29305462, PMCID: PMC6049088, DOI: 10.1126/sciimmunol.aao1680.Peer-Reviewed Original ResearchConceptsZika virus infectionZIKV infectionI IFNsI interferonType I interferonGrowth restrictionFetal demiseVirus infectionSevere fetal growth restrictionType I IFNsChorionic villous explantsAdverse fetal outcomesCongenital viral infectionFetal growth restrictionMaternal-fetal barrierType IFunctional type IPlacental damageFetal outcomesPregnancy complicationsEarly pregnancyFetal resorptionZIKV diseasePregnant damsSpontaneous abortion
2017
Estimated Placental Volume and Gestational Age
Isakov KMM, Emerson JW, Campbell KH, Galerneau F, Anders AM, Lee YK, Subramanyam P, Roberts AE, Kliman HJ. Estimated Placental Volume and Gestational Age. American Journal Of Perinatology 2017, 35: 748-757. PMID: 29281842, DOI: 10.1055/s-0037-1615285.Peer-Reviewed Original ResearchConceptsGestational ageBirth weightPlacental volumeSignificant placental pathologyWeeks gestational agePlacental pathologyUltrasound scanClinical utilityNormative curvesMicroscopic evaluationPatientsFurther validationVariety of settingsAgePercentileEPVDifferent populationsSubanalysisGestationNewbornsPlacentaPathology
2013
Trophoblast Inclusions Are Significantly Increased in the Placentas of Children in Families at Risk for Autism
Walker CK, Anderson KW, Milano KM, Ye S, Tancredi DJ, Pessah IN, Hertz-Picciotto I, Kliman HJ. Trophoblast Inclusions Are Significantly Increased in the Placentas of Children in Families at Risk for Autism. Biological Psychiatry 2013, 74: 204-211. PMID: 23623455, PMCID: PMC3755347, DOI: 10.1016/j.biopsych.2013.03.006.Peer-Reviewed Original ResearchConceptsElevated riskPlacentas of childrenTrophoblast inclusionsUncomplicated term pregnanciesAutism spectrum disorderPositive likelihood ratioTargeted early interventionsNeurodevelopmental compromiseMultiparous womenTerm pregnancyRisk pregnanciesBiological childrenControl placentasBehavioral symptomsEarly interventionNeurodevelopmental vulnerabilityPlacentaCritical windowRisk statusPregnancyRiskNewbornsChildrenDevelopmental outcomesControl samples
2008
The fetus, not the mother, elicits maternal immunologic rejection: lessons from discordant dizygotic twin placentas
Yusuf K, Kliman HJ. The fetus, not the mother, elicits maternal immunologic rejection: lessons from discordant dizygotic twin placentas. Journal Of Perinatal Medicine 2008, 36: 291-296. PMID: 18598117, DOI: 10.1515/jpm.2008.054.Peer-Reviewed Original ResearchConceptsChronic villitisTwin placentasT cellsMaternal immunologic rejectionMaternal immune responseNumerous T cellsBirth weight differenceMouse monoclonal antibodyWeight discordancePathologic evidenceDizygotic pregnanciesAutoimmune disordersImmunologic rejectionDichorionic placentasHistologic examinationImmune responseVillitisBacterial infectionsPlacentaMonoclonal antibodiesChorionic villiFetusesMaternal environmentWeight differencesVilli
2006
Placental Trophoblast Inclusions in Autism Spectrum Disorder
Anderson GM, Jacobs-Stannard A, Chawarska K, Volkmar FR, Kliman HJ. Placental Trophoblast Inclusions in Autism Spectrum Disorder. Biological Psychiatry 2006, 61: 487-491. PMID: 16806106, DOI: 10.1016/j.biopsych.2006.03.068.Peer-Reviewed Original Research
1995
A mucin-like glycoprotein identified by MAG (mouse ascites Golgi) antibodies. Menstrual cycle-dependent localization in human endometrium.
Kliman HJ, Feinberg RF, Schwartz LB, Feinman MA, Lavi E, Meaddough EL. A mucin-like glycoprotein identified by MAG (mouse ascites Golgi) antibodies. Menstrual cycle-dependent localization in human endometrium. American Journal Of Pathology 1995, 146: 166-81. PMID: 7531946, PMCID: PMC1870765.Peer-Reviewed Original ResearchConceptsMAG antibodyMucin-like glycoproteinHigh molecular weight mucin-like glycoproteinBlood groupCycle days 5Bile duct epitheliumAnti-MAG antibodiesConceptus-endometrial interactionsExpression of mucinsBlood type ABlood group AHuman endometrial glandsEndometrial biopsyPancreatic acinar cellsEndometrial glandsEndometrial surfaceIgG antibodiesImplantation windowHuman endometriumImmunohistochemical stainingGroup AGall bladderLuminal epitheliumDuct epitheliumLacrimal gland