2008
The fetus, not the mother, elicits maternal immunologic rejection: lessons from discordant dizygotic twin placentas
Yusuf K, Kliman HJ. The fetus, not the mother, elicits maternal immunologic rejection: lessons from discordant dizygotic twin placentas. Journal Of Perinatal Medicine 2008, 36: 291-296. PMID: 18598117, DOI: 10.1515/jpm.2008.054.Peer-Reviewed Original ResearchConceptsChronic villitisTwin placentasT cellsMaternal immunologic rejectionMaternal immune responseNumerous T cellsBirth weight differenceMouse monoclonal antibodyWeight discordancePathologic evidenceDizygotic pregnanciesAutoimmune disordersImmunologic rejectionDichorionic placentasHistologic examinationImmune responseVillitisBacterial infectionsPlacentaMonoclonal antibodiesChorionic villiFetusesMaternal environmentWeight differencesVilli
2006
Optimization of endometrial preparation results in a normal endometrial function test® (EFT®) and good reproductive outcome in donor ovum recipients
Kliman HJ, Honig S, Walls D, Luna M, McSweet JC, Copperman AB. Optimization of endometrial preparation results in a normal endometrial function test® (EFT®) and good reproductive outcome in donor ovum recipients. Journal Of Assisted Reproduction And Genetics 2006, 23: 299-303. PMID: 16983518, DOI: 10.1007/s10815-006-9061-1.Peer-Reviewed Original ResearchConceptsFunction testsCourse of estrogensOvum donation cyclesUnexplained infertility patientsBetter reproductive outcomesCyclin EOvum recipientsClinical pregnancyEndometrial biopsyInfertility patientsProgesterone supplementationSuch patientsEndometrial receptivityDonation cyclesSuccessful pregnancyPregnancy failureDonor oocytesLeuprolide acetateSole patientUterine preparationsImmunohistochemical stainingReproductive outcomesStimulation protocolTransfer cyclesSuccessful implantation
2003
Improved endometrial assessment using cyclin E and p27
Dubowy RL, Feinberg RF, Keefe DL, Doncel GF, Williams SC, McSweet JC, Kliman HJ. Improved endometrial assessment using cyclin E and p27. Fertility And Sterility 2003, 80: 146-156. PMID: 12849817, DOI: 10.1016/s0015-0282(03)00573-9.Peer-Reviewed Original ResearchMeSH KeywordsBiopsyCyclin EEndometriumFemaleHumansImmunohistochemistryInfertilityMenstrual CycleProliferating Cell Nuclear AntigenRetrospective StudiesConceptsCyclin EDay 20Retrospective clinical studyNormal control biopsiesUniversity Medical CenterEndometrial assessmentMock cycleP27 immunohistochemistryEndometrial biopsyControl biopsiesInfertile womenInfertility patientsEndometrial expressionMenstrual cycleInfertility treatmentClinical studiesMedical CenterMAIN OUTCOMEP27 stainingFertile volunteersP27 expressionDay 17Useful markerProliferative samplesBiopsy
2000
Endometrial dating and determination of the window of implantation in healthy fertile women
Acosta A, Elberger L, Borghi M, Calamera J, Chemes H, Doncel G, Kliman H, Lema B, Lustig L, Papier S. Endometrial dating and determination of the window of implantation in healthy fertile women. Fertility And Sterility 2000, 73: 788-798. PMID: 10731542, DOI: 10.1016/s0015-0282(99)00605-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultEmbryo ImplantationEndometriumEstradiolFemaleFollicle Stimulating HormoneGolgi ApparatusGrowth InhibitorsHumansImmunohistochemistryIntegrin alpha4beta1IntegrinsInterleukin-6Leukemia Inhibitory FactorLuteinizing HormoneLymphokinesMenstrual CycleMicroscopy, Electron, ScanningMucinsProspective StudiesReceptors, Interleukin-1Receptors, Interleukin-1 Type IReceptors, Lymphocyte HomingReceptors, ProgesteroneReceptors, VitronectinReference ValuesConceptsWindow of implantationLeukemia inhibitory factorLuteal phaseDay 22Day 20Endometrial datingInterleukin-1 receptor type IAssisted reproductive unitWhole luteal phaseProspective clinical studyHealthy fertile womenIL-1R tIReceptor type IMAG antibodyEndometrial biopsyFertile womenNormal womenImplantation windowP4 receptorReceptor expressionClinical studiesLH peakHealthy volunteersMAIN OUTCOMEImmunohistochemical determination
1996
Endocrinology and paracrinology
Arici A, Tazuke SI, Attar E, Kliman HJ, Olive DL. Endocrinology and paracrinology. Molecular Human Reproduction 1996, 2: 40-45. PMID: 9238656, DOI: 10.1093/molehr/2.1.40.Peer-Reviewed Original ResearchConceptsIL-8 mRNAIL-1 alphaEnzyme-linked immunosorbent assayIL-8 concentrationsPathogenesis of endometriosisInterleukin-8IL-8 proteinPeritoneal fluidMesothelial cellsPg/Human recombinant IL-1 alphaRecombinant IL-1 alphaNeutrophil chemotactic activityMinimal-mild endometriosisPeritoneal mesothelial cellsInterleukin-8 expressionCultured mesothelial cellsPotent angiogenic agentTNF-alpha treatmentModerate-severe endometriosisHuman mesothelial cellsNon-treated cellsControl patientsTime-dependent mannerTNF-alpha
1995
Monoclonal antibody X18A4 identifies on oncofetal fibronectin epitope distinct from the FDC-6 binding site
Feinberg R, Kliman H, Bedian V, Monzon-Bordonaba F, Menzin A, Wang C. Monoclonal antibody X18A4 identifies on oncofetal fibronectin epitope distinct from the FDC-6 binding site. American Journal Of Obstetrics And Gynecology 1995, 172: 1526-1536. PMID: 7538728, DOI: 10.1016/0002-9378(95)90491-3.Peer-Reviewed Original ResearchConceptsFDC-6Oncofetal fibronectinSimilar immunohistochemical stainingOvarian epithelial tumorsImmunoblot analysisTrophoblastic implantationPreterm laborSpecific monoclonal antibodiesEpithelial tumorsSpliced type IIIImmunohistochemical stainingNovel epitopesPlacental tissueAbnormal releaseVaginal secretionsCultured trophoblastsNew epitopesDistinct epitopesDetectable binding activityImmunosorbent assayMonoclonal antibodiesAntibodiesEpitopesType IIIComparative immunoassay
1991
Is oncofetal fibronectin a trophoblast glue for human implantation?
Feinberg RF, Kliman HJ, Lockwood CJ. Is oncofetal fibronectin a trophoblast glue for human implantation? American Journal Of Pathology 1991, 138: 537-43. PMID: 2000933, PMCID: PMC1886265.Peer-Reviewed Original Research
1989
Plasminogen activator inhibitor types 1 and 2 in human trophoblasts. PAI-1 is an immunocytochemical marker of invading trophoblasts.
Feinberg RF, Kao LC, Haimowitz JE, Queenan JT, Wun TC, Strauss JF, Kliman HJ. Plasminogen activator inhibitor types 1 and 2 in human trophoblasts. PAI-1 is an immunocytochemical marker of invading trophoblasts. Laboratory Investigation 1989, 61: 20-6. PMID: 2473276.Peer-Reviewed Original ResearchConceptsPAI-2Plasminogen activator inhibitorSpecific plasminogen activator inhibitorPAI-1Villous syncytiotrophoblastHuman trophoblastsCytoplasmic localizationPlasminogen activatorRegulated productionPAI expressionCytoplasmic stainingCell surface stainingCultured cytotrophoblastsProminent cytoplasmic stainingIntervillous blood flowPlasminogen activator inhibitor type 1Activator inhibitor type 1Inhibitor type 1First trimesterActivatorProteolytic enzymesVascular remodelingVillous cytotrophoblastsBlood flowImmunohistochemical analysis