1996
The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: a potential role in human implantation
Nachtigall MJ, Kliman HJ, Feinberg RF, Olive DL, Engin O, Arici A. The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: a potential role in human implantation. The Journal Of Clinical Endocrinology & Metabolism 1996, 81: 801-806. PMID: 8636307, DOI: 10.1210/jcem.81.2.8636307.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, NorthernCell DifferentiationCells, CulturedChorionic GonadotropinChorionic Gonadotropin, beta Subunit, HumanEmbryo ImplantationFemaleFibronectinsGene ExpressionGrowth InhibitorsHumansInterleukin-6Leukemia Inhibitory FactorLymphokinesPregnancyProgesteroneRNA, MessengerTrophoblastsConceptsLeukemia inhibitory factorHuman cytotrophoblastsMenstrual cycle-dependent mannerInhibitory factorOncofetal fibronectinEffects of LIFHuman implantationHuman embryonic implantationBeta-HCG mRNAOncofetal fibronectin mRNAMessenger RNA expressionExtravillous phenotypeBeta-hCGMenstrual cycleHuman endometriumNormal implantationEmbryonic implantationProgesterone productionHCG mRNATerm placentaBiochemical markersCultured trophoblastsHuman CGDay 19Steroidogenic activity
1995
Monoclonal antibody X18A4 identifies on oncofetal fibronectin epitope distinct from the FDC-6 binding site
Feinberg R, Kliman H, Bedian V, Monzon-Bordonaba F, Menzin A, Wang C. Monoclonal antibody X18A4 identifies on oncofetal fibronectin epitope distinct from the FDC-6 binding site. American Journal Of Obstetrics And Gynecology 1995, 172: 1526-1536. PMID: 7538728, DOI: 10.1016/0002-9378(95)90491-3.Peer-Reviewed Original ResearchConceptsFDC-6Oncofetal fibronectinSimilar immunohistochemical stainingOvarian epithelial tumorsImmunoblot analysisTrophoblastic implantationPreterm laborSpecific monoclonal antibodiesEpithelial tumorsSpliced type IIIImmunohistochemical stainingNovel epitopesPlacental tissueAbnormal releaseVaginal secretionsCultured trophoblastsNew epitopesDistinct epitopesDetectable binding activityImmunosorbent assayMonoclonal antibodiesAntibodiesEpitopesType IIIComparative immunoassay
1994
Transforming growth factor-beta stimulates trophoblast oncofetal fibronectin synthesis in vitro: implications for trophoblast implantation in vivo
Feinberg RF, Kliman HJ, Wang CL. Transforming growth factor-beta stimulates trophoblast oncofetal fibronectin synthesis in vitro: implications for trophoblast implantation in vivo. The Journal Of Clinical Endocrinology & Metabolism 1994, 78: 1241-1248. PMID: 8175984, DOI: 10.1210/jcem.78.5.8175984.Peer-Reviewed Original ResearchConceptsTGF beta 1TGF betaBeta 1Ability of trophoblastsAnti-TGF betaSevere alloimmune thrombocytopeniaThird trimester placentasPlatelet-poor serumDose-response analysisPregnancy tissueCord serumAlloimmune thrombocytopeniaCytokine presentUterine deciduaExtracellular matrixVillous syncytiotrophoblastTrimester placentaNormal serumHuman cytotrophoblastsGrowth factor-beta stimulatesOncofetal fibronectinNormal morphological differentiationCulture secreteStimulatory responseThrombocytopenic serum
1993
Tropho-uteronectin (tun): A unique oncofetal fibronectin deposited in the extracellular matrix of the tropho-uterine junction and regulated in vitro by cultured human trophoblast cells
Feinberg R, Kliman H. Tropho-uteronectin (tun): A unique oncofetal fibronectin deposited in the extracellular matrix of the tropho-uterine junction and regulated in vitro by cultured human trophoblast cells. Placenta 1993, 14: 167-179. DOI: 10.1016/s0143-4004(05)80292-9.Peer-Reviewed Original Research