Impaired B cell development and function in mice with a targeted disruption of the homeobox gene Hex
Bogue CW, Zhang PX, McGrath J, Jacobs HC, Fuleihan RL. Impaired B cell development and function in mice with a targeted disruption of the homeobox gene Hex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 556-561. PMID: 12522149, PMCID: PMC141034, DOI: 10.1073/pnas.0236979100.Peer-Reviewed Original ResearchConceptsB cell developmentB cellsChimeric miceT cell-dependent antigensT cell-independent antigensSerum IgM levelsCell developmentMature B cellsIgM levelsImpaired B cell developmentAntibody responseIgG antibodiesPlasma cellsBone marrowAbsence of HexLymphocyte developmentMiceTargeted disruptionHomozygous disruptionAntigenCellsHomeobox gene HexMarrowDramatic increaseAntibodies