1990
Corticosteroids and Intratracheal Surfactant Both Alter the Distribution between the Airways and Lung Tissue of Intratracheally Administered Radiolabeled Phosphatidylcholine in the Preterm Rabbit
Fiascone J, Mercurio M, Lima D, Jacobs H. Corticosteroids and Intratracheal Surfactant Both Alter the Distribution between the Airways and Lung Tissue of Intratracheally Administered Radiolabeled Phosphatidylcholine in the Preterm Rabbit. Experimental Lung Research 1990, 16: 311-321. PMID: 2394199, DOI: 10.3109/01902149009108847.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesAnimalsAnimals, NewbornBetamethasoneFemaleLungPhosphatidylcholinesPregnancyPulmonary AlveoliPulmonary SurfactantsRabbitsTracheaConceptsIntratracheal surfactantLung tissueAlveolar spaceCorticosteroid exposureMechanical ventilationRinger's lactateAntenatal corticosteroid exposurePrenatal corticosteroid exposurePreterm rabbitsLung clearanceIntratracheal injectionAlveolar lavageDay 25FetusesClearanceVentilationAirwayRadiolabel distributionLactateTissueRabbitsExposureRadiolabelCorticosteroidsLavage
1985
Reutilization of surfactant phosphatidylcholine in adult rabbits
Jacobs H, Ikegami M, Jobe A, Berry D, Jones S. Reutilization of surfactant phosphatidylcholine in adult rabbits. Biochimica Et Biophysica Acta 1985, 837: 77-84. PMID: 3840389, DOI: 10.1016/0005-2760(85)90087-6.Peer-Reviewed Original ResearchLung protein leaks in ventilated lambs: effects of gestational age
Jobe A, Jacobs H, Ikegami M, Berry D. Lung protein leaks in ventilated lambs: effects of gestational age. Journal Of Applied Physiology 1985, 58: 1246-1251. PMID: 3988678, DOI: 10.1152/jappl.1985.58.4.1246.Peer-Reviewed Original ResearchConceptsDays gestational ageGestational ageFull-term lambsGroups of lambsVentilated lambsLung tissueAlveolar washBlood gas valuesNatural sheep surfactantPremature lambsPreterm lambsPremature lungIntravascular injectionSheep surfactantLung proteinGas valuesPCO2 valuesAgeAlveoliAirwayLambsBidirectional fluxesTissueGroupAlbuminClearance of Large Amounts of Natural Surfactants and Liposomes of Dipalmitoylphosphatidylcholine from the Lungs of Rabbits
Oguchi K, Ikegami M, Jacobs H, Jobe A. Clearance of Large Amounts of Natural Surfactants and Liposomes of Dipalmitoylphosphatidylcholine from the Lungs of Rabbits. Experimental Lung Research 1985, 9: 221-235. PMID: 3841050, DOI: 10.3109/01902148509057525.Peer-Reviewed Original ResearchConceptsTotal lungLung tissueRabbit surfactantAlveolar washSheep surfactantAlveolar surfactant pool sizeEndogenous surfactant metabolismEndogenous surfactant poolsSurfactant pool sizeDifferent surfactant preparationsNatural rabbit surfactantLungs of rabbitsNatural sheep surfactantIntratracheal administrationIntratracheal injectionLung phosphatidylcholineSurfactant poolQuantity of phosphatidylcholineSurfactant metabolismLungClearance rateSurfactant phosphatidylcholineTotal phosphatidylcholineMetabolic responseSurfactant preparations
1984
Lack of correlation of severity of lung disease with the phosphatidylcholine concentration in fetal lung fluid from premature lambs at 133-136 days gestational age.
Jobe A, Jacobs H, Ikegami M. Lack of correlation of severity of lung disease with the phosphatidylcholine concentration in fetal lung fluid from premature lambs at 133-136 days gestational age. Journal Of Developmental Physiology 1984, 6: 417-21. PMID: 6568247.Peer-Reviewed Original ResearchConceptsFetal lung fluidPeak inspiratory pressureDays gestational ageLung diseaseLung fluidPremature lambsGestational ageInspiratory pressureConcentration of phosphatidylcholinePhosphatidylcholine concentrationNarrow gestational age rangePhosphatidylcholine pool sizesGestational age rangeTime of deliveryLung compliance valuesMechanical ventilationAlveolar washTotal phosphatidylcholineDiseaseAge rangeSeverityLack of correlationAgeLambsCompliance valuesReutilization of phosphatidylcholine analogues by the pulmonary surfactant system The lack of specificity
Jacobs H, Jobe A, Machiko I, Miller D, Jones S. Reutilization of phosphatidylcholine analogues by the pulmonary surfactant system The lack of specificity. Biochimica Et Biophysica Acta 1984, 793: 300-309. PMID: 6546884, DOI: 10.1016/0005-2760(84)90333-3.Peer-Reviewed Original ResearchAdrenal Epinephrine and the Regulation of Pulmonary Surfactant Release in Neonatal Rabbits
Padbury J, Jacobs H, Lam R, Conaway D, Jobe A, Fisher D. Adrenal Epinephrine and the Regulation of Pulmonary Surfactant Release in Neonatal Rabbits. Experimental Lung Research 1984, 7: 177-186. PMID: 6549291, DOI: 10.3109/01902148409087911.Peer-Reviewed Original ResearchConceptsAdrenal E contentPulmonary surfactant releaseSKF 29661Surfactant releaseFetal adrenal glandE contentEpinephrine synthesisMaternal doseNeonatal periodAdrenal epinephrineAdrenal glandPregnant rabbitsNeonatal rabbitsAlveolar washPhosphatidylcholine contentBirthRabbitsAgeReleaseEpinephrineDoseSecretion
1981
Changes in the amount of lung and airway phosphatidylcholine in 0.5–12.5-day-old rabbits
Jobe A, Ikegami M, Jacobs H. Changes in the amount of lung and airway phosphatidylcholine in 0.5–12.5-day-old rabbits. Biochimica Et Biophysica Acta 1981, 664: 182-187. PMID: 6894550, DOI: 10.1016/0005-2760(81)90040-0.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsBody WeightLungPhosphatidylcholinesProteinsPulmonary AlveoliPulmonary SurfactantsRabbitsTherapeutic Irrigation