1990
Corticosteroids and Intratracheal Surfactant Both Alter the Distribution between the Airways and Lung Tissue of Intratracheally Administered Radiolabeled Phosphatidylcholine in the Preterm Rabbit
Fiascone J, Mercurio M, Lima D, Jacobs H. Corticosteroids and Intratracheal Surfactant Both Alter the Distribution between the Airways and Lung Tissue of Intratracheally Administered Radiolabeled Phosphatidylcholine in the Preterm Rabbit. Experimental Lung Research 1990, 16: 311-321. PMID: 2394199, DOI: 10.3109/01902149009108847.Peer-Reviewed Original ResearchConceptsIntratracheal surfactantLung tissueAlveolar spaceCorticosteroid exposureMechanical ventilationRinger's lactateAntenatal corticosteroid exposurePrenatal corticosteroid exposurePreterm rabbitsLung clearanceIntratracheal injectionAlveolar lavageDay 25FetusesClearanceVentilationAirwayRadiolabel distributionLactateTissueRabbitsExposureRadiolabelCorticosteroidsLavage
1987
Betamethasone Increases Pulmonary Compliance in Part by Surfactant-Independent Mechanisms in Preterm Rabbits
Fiascone J, Jacobs H, Moya F, Mercurio M, Lima D. Betamethasone Increases Pulmonary Compliance in Part by Surfactant-Independent Mechanisms in Preterm Rabbits. Pediatric Research 1987, 22: 730-735. PMID: 3431959, DOI: 10.1203/00006450-198712000-00024.Peer-Reviewed Original ResearchConceptsAntenatal corticosteroidsIntratracheal surfactantPulmonary complianceDynamic complianceAlveolar surfactant contentHigher dynamic complianceAntenatal exposurePreterm rabbitsPreterm animalsSingle therapyAlveolar lavageTidal volumeCorticosteroidsFirst breathFetusesDay 25Compliance studiesVentilationRabbitsComplianceCompliance measurementsLavageGestationBetamethasoneTherapy
1985
Normalization of Arterial Blood Gases after Treatment of Surfactant-Deficient Lambs with Tween 201–3
Jacobs H, Berry D, Duane G, Ikegami M, Jobe A, Jones S. Normalization of Arterial Blood Gases after Treatment of Surfactant-Deficient Lambs with Tween 201–3. American Journal Of Respiratory And Critical Care Medicine 1985, 132: 1313-8. PMID: 3935021, DOI: 10.1164/arrd.1985.132.6.1313.Peer-Reviewed Original ResearchConceptsPeak inspiratory pressurePulmonary surfactantAdequate ventilationMinimal surface tensionArterial blood gasesNormal lung functionMin of ageRespiratory failureLung functionLung complianceInspiratory pressureBlood gasesInfant ventilatorDays gestationAlveolar washControl animalsControl lambsPoor oxygenationSurfactant treatmentGas exchangeTreatmentVentilationLambsGestationVentilator
1984
Surfactant and pulmonary blood flow distributions following treatment of premature lambs with natural surfactant.
Jobe A, Ikegami M, Jacobs H, Jones S. Surfactant and pulmonary blood flow distributions following treatment of premature lambs with natural surfactant. Journal Of Clinical Investigation 1984, 73: 848-856. PMID: 6546766, PMCID: PMC425089, DOI: 10.1172/jci111280.Peer-Reviewed Original ResearchConceptsPieces of lungBlood flow distributionPulmonary blood flow distributionLungs of lambsMechanical ventilationRight ductal shuntPulmonary blood flowConstant distending pressurePeriod of ventilationGroups of lambsDuctal shuntPremature lambsAtelectatic areasSurfactant instillationVentricular outputTracheal instillationDistending pressureBlood flowLungLung piecesVentilationInstillationBirthLambsNatural surfactant