1989
Antenatal steroids, postnatal surfactant, and pulmonary function in premature rabbits
Gladstone I, Mercurio M, Devenny S, Jacobs H. Antenatal steroids, postnatal surfactant, and pulmonary function in premature rabbits. Journal Of Applied Physiology 1989, 67: 1377-1382. PMID: 2793738, DOI: 10.1152/jappl.1989.67.4.1377.Peer-Reviewed Original ResearchConceptsDynamic compliancePulmonary functionLung resistanceTotal lung conductanceTotal lung resistancePulmonary function testsRespiratory distress syndromeConsistent tidal volumeAntenatal corticosteroidsAntenatal steroidsIntramuscular betamethasonePostnatal surfactantDistress syndromeFunction testsCombination therapyPulmonary mechanicsExpiratory timePremature rabbitsTidal volumeStatic complianceLung conductanceFirst breathDay 27Day 25Steroids
1987
Betamethasone Increases Pulmonary Compliance in Part by Surfactant-Independent Mechanisms in Preterm Rabbits
Fiascone J, Jacobs H, Moya F, Mercurio M, Lima D. Betamethasone Increases Pulmonary Compliance in Part by Surfactant-Independent Mechanisms in Preterm Rabbits. Pediatric Research 1987, 22: 730-735. PMID: 3431959, DOI: 10.1203/00006450-198712000-00024.Peer-Reviewed Original ResearchConceptsAntenatal corticosteroidsIntratracheal surfactantPulmonary complianceDynamic complianceAlveolar surfactant contentHigher dynamic complianceAntenatal exposurePreterm rabbitsPreterm animalsSingle therapyAlveolar lavageTidal volumeCorticosteroidsFirst breathFetusesDay 25Compliance studiesVentilationRabbitsComplianceCompliance measurementsLavageGestationBetamethasoneTherapy
1985
Leakage of protein in the immature rabbit lung; effect of surfactant replacement
Robertson B, Berry D, Curstedt T, Grossmann G, Machiko I, Jacobs H, Jobe A, Jones S. Leakage of protein in the immature rabbit lung; effect of surfactant replacement. Respiratory Physiology & Neurobiology 1985, 61: 265-276. PMID: 3840603, DOI: 10.1016/0034-5687(85)90070-2.Peer-Reviewed Original ResearchConceptsSurfactant-treated animalsControl animalsSurfactant replacementAlveolar wash samplesOnset of ventilationAverage tidal volumeImmature rabbit lungsImmature newborn rabbitsInsufflation pressureImmature lungSurfactant inhibitorsTidal volumeRabbit lungsAlveolar compartmentNewborn rabbitsDay 27Wash samplesPrevious treatmentLeakage of proteins
1983
Surfactant Pool Sizes and Severity of Respiratory Distress Syndrome in Prematurely Delivered Lambs1–3
Jobe A, Ikegami M, Jacobs H, Jones S. Surfactant Pool Sizes and Severity of Respiratory Distress Syndrome in Prematurely Delivered Lambs1–3. American Journal Of Respiratory And Critical Care Medicine 1983, 127: 751-5. PMID: 6552894, DOI: 10.1164/arrd.1983.127.6.751.Peer-Reviewed Original ResearchConceptsLung diseaseAlveolar washCompliant lungsMinimal surface tensionLow minimal surface tensionRespiratory distress syndromePeak inspiratory pressurePhosphatidylcholine pool sizesDays gestational ageSurfactant pool sizePremature lambsDistress syndromeGestational ageInspiratory pressureLung tissueRespiratory diseaseTidal volumeLung slicesSurfactant phosphatidylcholineTotal phosphatidylcholineDiseaseSeverityPool sizeRate of incorporationLung