1990
Corticosteroids and Intratracheal Surfactant Both Alter the Distribution between the Airways and Lung Tissue of Intratracheally Administered Radiolabeled Phosphatidylcholine in the Preterm Rabbit
Fiascone J, Mercurio M, Lima D, Jacobs H. Corticosteroids and Intratracheal Surfactant Both Alter the Distribution between the Airways and Lung Tissue of Intratracheally Administered Radiolabeled Phosphatidylcholine in the Preterm Rabbit. Experimental Lung Research 1990, 16: 311-321. PMID: 2394199, DOI: 10.3109/01902149009108847.Peer-Reviewed Original ResearchConceptsIntratracheal surfactantLung tissueAlveolar spaceCorticosteroid exposureMechanical ventilationRinger's lactateAntenatal corticosteroid exposurePrenatal corticosteroid exposurePreterm rabbitsLung clearanceIntratracheal injectionAlveolar lavageDay 25FetusesClearanceVentilationAirwayRadiolabel distributionLactateTissueRabbitsExposureRadiolabelCorticosteroidsLavage
1985
Lung protein leaks in ventilated lambs: effects of gestational age
Jobe A, Jacobs H, Ikegami M, Berry D. Lung protein leaks in ventilated lambs: effects of gestational age. Journal Of Applied Physiology 1985, 58: 1246-1251. PMID: 3988678, DOI: 10.1152/jappl.1985.58.4.1246.Peer-Reviewed Original ResearchConceptsDays gestational ageGestational ageFull-term lambsGroups of lambsVentilated lambsLung tissueAlveolar washBlood gas valuesNatural sheep surfactantPremature lambsPreterm lambsPremature lungIntravascular injectionSheep surfactantLung proteinGas valuesPCO2 valuesAgeAlveoliAirwayLambsBidirectional fluxesTissueGroupAlbuminClearance of Large Amounts of Natural Surfactants and Liposomes of Dipalmitoylphosphatidylcholine from the Lungs of Rabbits
Oguchi K, Ikegami M, Jacobs H, Jobe A. Clearance of Large Amounts of Natural Surfactants and Liposomes of Dipalmitoylphosphatidylcholine from the Lungs of Rabbits. Experimental Lung Research 1985, 9: 221-235. PMID: 3841050, DOI: 10.3109/01902148509057525.Peer-Reviewed Original ResearchConceptsTotal lungLung tissueRabbit surfactantAlveolar washSheep surfactantAlveolar surfactant pool sizeEndogenous surfactant metabolismEndogenous surfactant poolsSurfactant pool sizeDifferent surfactant preparationsNatural rabbit surfactantLungs of rabbitsNatural sheep surfactantIntratracheal administrationIntratracheal injectionLung phosphatidylcholineSurfactant poolQuantity of phosphatidylcholineSurfactant metabolismLungClearance rateSurfactant phosphatidylcholineTotal phosphatidylcholineMetabolic responseSurfactant preparations
1984
A protein from airways of premature lambs that inhibits surfactant function
Ikegami M, Jobe A, Jacobs H, Lam R. A protein from airways of premature lambs that inhibits surfactant function. Journal Of Applied Physiology 1984, 57: 1134-1142. PMID: 6209255, DOI: 10.1152/jappl.1984.57.4.1134.Peer-Reviewed Original Research
1983
Surfactant Pool Sizes and Severity of Respiratory Distress Syndrome in Prematurely Delivered Lambs1–3
Jobe A, Ikegami M, Jacobs H, Jones S. Surfactant Pool Sizes and Severity of Respiratory Distress Syndrome in Prematurely Delivered Lambs1–3. American Journal Of Respiratory And Critical Care Medicine 1983, 127: 751-5. PMID: 6552894, DOI: 10.1164/arrd.1983.127.6.751.Peer-Reviewed Original ResearchConceptsLung diseaseAlveolar washCompliant lungsMinimal surface tensionLow minimal surface tensionRespiratory distress syndromePeak inspiratory pressurePhosphatidylcholine pool sizesDays gestational ageSurfactant pool sizePremature lambsDistress syndromeGestational ageInspiratory pressureLung tissueRespiratory diseaseTidal volumeLung slicesSurfactant phosphatidylcholineTotal phosphatidylcholineDiseaseSeverityPool sizeRate of incorporationLung