1997
Repeated Doses of the Perfluorocarbon FC-100 Improve Lung Function of Preterm Lambs
Moya F, Llanos A, Ríos A, Riquelme R, Moraga F, Rubio L, Salvo H, Jacobs H. Repeated Doses of the Perfluorocarbon FC-100 Improve Lung Function of Preterm Lambs. Pediatric Research 1997, 42: 893-898. PMID: 9396575, DOI: 10.1203/00006450-199712000-00028.Peer-Reviewed Original ResearchConceptsLung functionPreterm lambsInitial doseIntratracheal administrationFC-100Administration of ExosurfSurfactant-deficient animalsSynthetic surfactant ExosurfArterial blood pressureDynamic lung compliancePreterm neonatesBlood pressureLung complianceSingle doseArterial PO2Arterial PCO2Surfactant deficiencyHeart rateAdditional doseExosurfStudy periodDoseAdministrationDosesSimilar changes
1990
Effect of artificial surfactant on pulmonary function in preterm and full-term lambs
Gladstone I, Ray A, Salafia C, Perez-Fontan J, Mercurio M, Jacobs H. Effect of artificial surfactant on pulmonary function in preterm and full-term lambs. Journal Of Applied Physiology 1990, 69: 465-472. PMID: 2121700, DOI: 10.1152/jappl.1990.69.2.465.Peer-Reviewed Original ResearchConceptsFunctional residual capacityFull-term lambsMean lung volumePreterm lambsLung volumeResidual capacityTest agentsFC-100Higher minimum surface tensionsRespiratory failureLung functionPulmonary functionLung expansionAlveolar washMinimum surface tensionDynamic complianceArtificial surfactantQualitative histologyOxygenationLambsAgentsGas exchangePretermComplianceHistology
1985
Normalization of Arterial Blood Gases after Treatment of Surfactant-Deficient Lambs with Tween 201–3
Jacobs H, Berry D, Duane G, Ikegami M, Jobe A, Jones S. Normalization of Arterial Blood Gases after Treatment of Surfactant-Deficient Lambs with Tween 201–3. American Journal Of Respiratory And Critical Care Medicine 1985, 132: 1313-8. PMID: 3935021, DOI: 10.1164/arrd.1985.132.6.1313.Peer-Reviewed Original ResearchConceptsPeak inspiratory pressurePulmonary surfactantAdequate ventilationMinimal surface tensionArterial blood gasesNormal lung functionMin of ageRespiratory failureLung functionLung complianceInspiratory pressureBlood gasesInfant ventilatorDays gestationAlveolar washControl animalsControl lambsPoor oxygenationSurfactant treatmentGas exchangeTreatmentVentilationLambsGestationVentilator
1983
Cardiovascular Effects of Surfactant Suspensions Given by Tracheal Instillation to Premature Lambs
Jobe A, Jacobs H, Ikegami M, Jones S. Cardiovascular Effects of Surfactant Suspensions Given by Tracheal Instillation to Premature Lambs. Pediatric Research 1983, 17: 444-448. PMID: 6553821, DOI: 10.1203/00006450-198306000-00002.Peer-Reviewed Original ResearchConceptsSurfactant instillationPremature lambsOnly ventilator settingPulmonary artery pressureDays gestational ageSurfactant treatmentArtery pressureCesarean sectionRespiratory supportCardiovascular effectsLung functionGestational ageCardiovascular statusInspiratory pressureRespiratory statusTransient deteriorationCardiac outputAortic pressureTracheal instillationVentilator settingsInfant ventilatorRegional bloodHeart rateInstillationBody weight