1985
Effects of high-frequency and conventional ventilation on the premature lamb lung
Solimano A, Bryan C, Jobe A, Ikegami M, Jacobs H. Effects of high-frequency and conventional ventilation on the premature lamb lung. Journal Of Applied Physiology 1985, 59: 1571-1577. PMID: 3840801, DOI: 10.1152/jappl.1985.59.5.1571.Peer-Reviewed Original ResearchConceptsMean airway pressureConventional mechanical ventilationProtein leakPremature lamb lungsFetal lung fluidRespiratory distress syndromeDays gestational ageDegree of leakHigh-frequency oscillationsGroups of lambsAirway pressureCesarean sectionDistress syndromeGestational ageConventional ventilationMechanical ventilationPathological findingsLung diseaseBlood gasesImmature lungVentilator settingsEpithelial necrosisBlood gasLung sectionsTracer doseLung protein leaks in ventilated lambs: effects of gestational age
Jobe A, Jacobs H, Ikegami M, Berry D. Lung protein leaks in ventilated lambs: effects of gestational age. Journal Of Applied Physiology 1985, 58: 1246-1251. PMID: 3988678, DOI: 10.1152/jappl.1985.58.4.1246.Peer-Reviewed Original ResearchConceptsDays gestational ageGestational ageFull-term lambsGroups of lambsVentilated lambsLung tissueAlveolar washBlood gas valuesNatural sheep surfactantPremature lambsPreterm lambsPremature lungIntravascular injectionSheep surfactantLung proteinGas valuesPCO2 valuesAgeAlveoliAirwayLambsBidirectional fluxesTissueGroupAlbumin
1984
Surfactant and pulmonary blood flow distributions following treatment of premature lambs with natural surfactant.
Jobe A, Ikegami M, Jacobs H, Jones S. Surfactant and pulmonary blood flow distributions following treatment of premature lambs with natural surfactant. Journal Of Clinical Investigation 1984, 73: 848-856. PMID: 6546766, PMCID: PMC425089, DOI: 10.1172/jci111280.Peer-Reviewed Original ResearchConceptsPieces of lungBlood flow distributionPulmonary blood flow distributionLungs of lambsMechanical ventilationRight ductal shuntPulmonary blood flowConstant distending pressurePeriod of ventilationGroups of lambsDuctal shuntPremature lambsAtelectatic areasSurfactant instillationVentricular outputTracheal instillationDistending pressureBlood flowLungLung piecesVentilationInstillationBirthLambsNatural surfactant
1981
Sequential treatments of premature lambs with an artificial surfactant and natural surfactant.
Ikegami M, Jobe A, Jacobs H, Jones S. Sequential treatments of premature lambs with an artificial surfactant and natural surfactant. Journal Of Clinical Investigation 1981, 68: 491-496. PMID: 6790576, PMCID: PMC370823, DOI: 10.1172/jci110280.Peer-Reviewed Original ResearchConceptsArtificial surfactantPremature lambsGestational age lambsFetal lung fluidPO2 valuesGroups of lambsPressure-volume characteristicsMinimum surface tensionPremature lungAirway samplesNatural surfactant lipidAge lambsUntreated lambsMean pO2 valuesMinimal surface tensionLung fluidSurfactant lipidsSequential treatmentTreatmentNatural surfactantLambsHgPCO2 valuesAirwayLung