1985
Effects of high-frequency and conventional ventilation on the premature lamb lung
Solimano A, Bryan C, Jobe A, Ikegami M, Jacobs H. Effects of high-frequency and conventional ventilation on the premature lamb lung. Journal Of Applied Physiology 1985, 59: 1571-1577. PMID: 3840801, DOI: 10.1152/jappl.1985.59.5.1571.Peer-Reviewed Original ResearchConceptsMean airway pressureConventional mechanical ventilationProtein leakPremature lamb lungsFetal lung fluidRespiratory distress syndromeDays gestational ageDegree of leakHigh-frequency oscillationsGroups of lambsAirway pressureCesarean sectionDistress syndromeGestational ageConventional ventilationMechanical ventilationPathological findingsLung diseaseBlood gasesImmature lungVentilator settingsEpithelial necrosisBlood gasLung sectionsTracer dose
1984
Lack of correlation of severity of lung disease with the phosphatidylcholine concentration in fetal lung fluid from premature lambs at 133-136 days gestational age.
Jobe A, Jacobs H, Ikegami M. Lack of correlation of severity of lung disease with the phosphatidylcholine concentration in fetal lung fluid from premature lambs at 133-136 days gestational age. Journal Of Developmental Physiology 1984, 6: 417-21. PMID: 6568247.Peer-Reviewed Original ResearchConceptsFetal lung fluidPeak inspiratory pressureDays gestational ageLung diseaseLung fluidPremature lambsGestational ageInspiratory pressureConcentration of phosphatidylcholinePhosphatidylcholine concentrationNarrow gestational age rangePhosphatidylcholine pool sizesGestational age rangeTime of deliveryLung compliance valuesMechanical ventilationAlveolar washTotal phosphatidylcholineDiseaseAge rangeSeverityLack of correlationAgeLambsCompliance values
1981
Sequential treatments of premature lambs with an artificial surfactant and natural surfactant.
Ikegami M, Jobe A, Jacobs H, Jones S. Sequential treatments of premature lambs with an artificial surfactant and natural surfactant. Journal Of Clinical Investigation 1981, 68: 491-496. PMID: 6790576, PMCID: PMC370823, DOI: 10.1172/jci110280.Peer-Reviewed Original ResearchConceptsArtificial surfactantPremature lambsGestational age lambsFetal lung fluidPO2 valuesGroups of lambsPressure-volume characteristicsMinimum surface tensionPremature lungAirway samplesNatural surfactant lipidAge lambsUntreated lambsMean pO2 valuesMinimal surface tensionLung fluidSurfactant lipidsSequential treatmentTreatmentNatural surfactantLambsHgPCO2 valuesAirwayLung