1985
Effects of high-frequency and conventional ventilation on the premature lamb lung
Solimano A, Bryan C, Jobe A, Ikegami M, Jacobs H. Effects of high-frequency and conventional ventilation on the premature lamb lung. Journal Of Applied Physiology 1985, 59: 1571-1577. PMID: 3840801, DOI: 10.1152/jappl.1985.59.5.1571.Peer-Reviewed Original ResearchConceptsMean airway pressureConventional mechanical ventilationProtein leakPremature lamb lungsFetal lung fluidRespiratory distress syndromeDays gestational ageDegree of leakHigh-frequency oscillationsGroups of lambsAirway pressureCesarean sectionDistress syndromeGestational ageConventional ventilationMechanical ventilationPathological findingsLung diseaseBlood gasesImmature lungVentilator settingsEpithelial necrosisBlood gasLung sectionsTracer doseAccumulation of Alveolar Surfactant Following Delivery and Ventilation of Premature Lambs
Jacobs H, Jobe A, Ikegami M, Jones S. Accumulation of Alveolar Surfactant Following Delivery and Ventilation of Premature Lambs. Experimental Lung Research 1985, 8: 125-140. PMID: 3839748, DOI: 10.3109/01902148509057517.Peer-Reviewed Original ResearchConceptsAlveolar washTreatment doseAlveolar surfactantMean gestational ageArterial blood gasPeak inspiratory pressureMin of ageSurfactant pool sizeAlveolar surfactant accumulationPhosphatidylcholine specific activityCesarean sectionPremature lambsGestational agePremature lungInspiratory pressureIntratracheal administrationBlood gasTrace doseDilution techniqueDoseAgeAirwayPool sizeBirthAccumulation of surfactant
1982
Premature Lambs Rescued from Respiratory Failure with Natural Surfactant: Clinical and Biophysical Correlates
Jacobs H, Jobe A, Ikegami M, Glatz T, Jones S, Barajas L. Premature Lambs Rescued from Respiratory Failure with Natural Surfactant: Clinical and Biophysical Correlates. Pediatric Research 1982, 16: 424-429. PMID: 6920645, DOI: 10.1203/00006450-198206000-00005.Peer-Reviewed Original ResearchConceptsRespiratory failureDistal airwaysRespiratory distress syndromeMin of ageDays gestational agePressure-volume curvesClinical deteriorationClinical responsePremature lambsDistress syndromePosttreatment groupGestational ageMechanical ventilationProgressive dilatationUntreated lungsPremature babiesTracheal instillationBlood gasAlveolar washSurfactant replacementBody weightLung structureAirwayMinimum surface tensionHistologic measurements