2023
Sex-Related Differences in Patient Characteristics, Risk Factors, and Symptomatology in Older Adults with Pulmonary Embolism: Findings from the SERIOUS-PE Study
Bikdeli B, Muriel A, Wang Y, Piazza G, Khairani C, Rosovsky R, Mehdipoor G, O'Donoghue M, Madridano O, Lopez-Saez J, Mellado M, Brasero A, Grandone E, Spagnolo P, Lu Y, Bertoletti L, López-Jiménez L, Núñez M, Blanco-Molina Á, Gerhard-Herman M, Goldhaber S, Bates S, Jimenez D, Krumholz H, Monreal M. Sex-Related Differences in Patient Characteristics, Risk Factors, and Symptomatology in Older Adults with Pulmonary Embolism: Findings from the SERIOUS-PE Study. Seminars In Thrombosis And Hemostasis 2023, 49: 725-735. PMID: 36868268, DOI: 10.1055/s-0043-1764231.Peer-Reviewed Original ResearchConceptsOlder adultsClinical characteristicsRisk factorsElderly womenPE risk stratificationTransient provoking factorsRelevant clinical characteristicsSex differencesWarrants further investigationSex-related differencesSex-specific factorsClot burdenPE presentationChest painHormonal therapyHormone therapyPatient characteristicsPulmonary embolismYounger patientsAtherosclerotic diseaseRisk stratificationLung diseaseMedicare databaseProvoking factorsCardiovascular disease
2021
Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival
Yang DX, Khera R, Miccio JA, Jairam V, Chang E, Yu JB, Park HS, Krumholz HM, Aneja S. Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival. JAMA Network Open 2021, 4: e211793. PMID: 33755165, PMCID: PMC7988369, DOI: 10.1001/jamanetworkopen.2021.1793.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseNon-small cell lung cancerOverall survivalCell lung cancerCancer DatabaseMedical recordsLung cancerProstate cancerBreast cancerPatient recordsComplete dataRetrospective cohort studyCohort studyCancer RegistryCommon cancerVariables of interestHigh prevalenceMAIN OUTCOMEPatientsClinical advancementReal-world data sourcesCancerPrevalenceSurvivalHeterogeneous differences
2007
The Impact of Venous Thromboembolism on Risk of Death or Hemorrhage in Older Cancer Patients
Gross CP, Galusha DH, Krumholz HM. The Impact of Venous Thromboembolism on Risk of Death or Hemorrhage in Older Cancer Patients. Journal Of General Internal Medicine 2007, 22: 321-326. PMID: 17356962, PMCID: PMC1824718, DOI: 10.1007/s11606-006-0019-x.Peer-Reviewed Original ResearchConceptsRisk of deathOlder cancer patientsConcomitant venous thromboembolismVenous thromboembolismMajor hemorrhageCancer patientsCancer typesCancer diagnosisMedicare administrative claims dataPrevalence of VTEEnd Results cancer registryRetrospective cohort studyAdministrative claims dataCohort studyCancer RegistryInvasive cancerExcess riskMost cancer typesCancer stageClaims dataHemorrhagePatientsSociodemographic factorsPotential mediatorsDeath
2005
Enrolling Older Persons in Cancer Trials: The Effect of Sociodemographic, Protocol, and Recruitment Center Characteristics
Gross CP, Herrin J, Wong N, Krumholz HM. Enrolling Older Persons in Cancer Trials: The Effect of Sociodemographic, Protocol, and Recruitment Center Characteristics. Journal Of Clinical Oncology 2005, 23: 4755-4763. PMID: 16034051, DOI: 10.1200/jco.2005.14.365.Peer-Reviewed Original ResearchConceptsCancer trialsOlder personsRecruitment centerElderly enrollmentProportion of patientsEffect of patientProstate cancer trialsPatient-level variationFinal study sampleNational Cancer InstituteCross-sectional analysisEffects of sociodemographicsNonwhite patientsTrial participantsOutlier centersCancer InstitutePatientsEnrollment centerMultivariate analysisLikelihood of participantsCancer typesLogistic multilevel modelsTrialsCenter characteristicsStudy sampleEnrollment of Older Persons in Cancer Trials After the Medicare Reimbursement Policy Change
Gross CP, Wong N, Dubin JA, Mayne ST, Krumholz HM. Enrollment of Older Persons in Cancer Trials After the Medicare Reimbursement Policy Change. JAMA Internal Medicine 2005, 165: 1514-1520. PMID: 16009867, DOI: 10.1001/archinte.165.13.1514.Peer-Reviewed Original ResearchConceptsOlder patientsCancer trialsReimbursement policy changesOlder personsPatients' sociodemographic characteristicsTrial exclusion criteriaMultivariate logistic regressionProstate cancer trialsProportion of participantsNational Cancer InstituteRoutine care costsSignificant changesClinical trialsPrimary study sampleExclusion criteriaTrial participantsCancer InstitutePatientsPrimary analysisCare costsMultivariate analysisSecondary analysisSociodemographic characteristicsLogistic regressionCancer types
2004
Cancer Trial Enrollment After State-Mandated Reimbursement
Gross CP, Murthy V, Li Y, Kaluzny AD, Krumholz HM. Cancer Trial Enrollment After State-Mandated Reimbursement. Journal Of The National Cancer Institute 2004, 96: 1063-1069. PMID: 15265967, DOI: 10.1093/jnci/djh193.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsClinical Trials, Phase II as TopicClinical Trials, Phase III as TopicColorectal NeoplasmsFemaleGovernment RegulationHumansIncidenceLogistic ModelsLongitudinal StudiesLung NeoplasmsMaleMulticenter Studies as TopicNational Institutes of Health (U.S.)NeoplasmsPatient SelectionPoisson DistributionProstatic NeoplasmsReimbursement MechanismsRetrospective StudiesState GovernmentUnited StatesConceptsCancer trial enrollmentTrial enrollment ratesTrial enrollmentMultivariable analysisTrial participationOdds ratioTrial participantsCoverage policiesCancer trial participantsCooperative group trialsClinical trial enrollmentEarly phase trialsRecruitment of patientsCancer trial participationMedical care costsPhase II trial participantsCancer patientsPhase trialsCancer research studiesGroup trialsCare costsPoisson regressionCancer typesReimbursement policiesPhase IIParticipation in Cancer Clinical Trials: Race-, Sex-, and Age-Based Disparities
Murthy VH, Krumholz HM, Gross CP. Participation in Cancer Clinical Trials: Race-, Sex-, and Age-Based Disparities. JAMA 2004, 291: 2720-2726. PMID: 15187053, DOI: 10.1001/jama.291.22.2720.Peer-Reviewed Original ResearchConceptsCancer trialsCancer clinical trialsClinical trialsTrial participantsEnrollment fractionWhite patientsAge groupsCross-sectional population-based analysisProstate cancer clinical trialsCancer research participationCancer trial participantsColorectal cancer trialsPatients 75 yearsIncident cancer patientsLung cancer trialsPopulation-based analysisRelative risk ratiosAge-based disparitiesYears of ageNational Cancer InstituteLogistic regression modelsLittle recent informationTrial enrolleesYounger patientsPatient group
2003
Are Statins Indicated for the Primary Prevention of CAD in Octogenarians? Angagonist Viewpoint
Foody JM, Krumholz HM. Are Statins Indicated for the Primary Prevention of CAD in Octogenarians? Angagonist Viewpoint. The American Journal Of Geriatric Cardiology 2003, 12: 357-360. PMID: 14610384, DOI: 10.1111/j.1076-7460.2003.02912.x.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePrimary preventionArtery diseaseOvert coronary artery diseaseRisk of myositisCardiovascular disease eventsRole of statinsUse of statinsAge 65 yearsBalance of risksCardiovascular eventsStatin therapyPatient preferencesCholesterol levelsCardiovascular diseaseOctogenariansClinical uncertaintyDisease eventsCurrent evidenceStatinsAge groupsDiseasePreventionRiskMyositis