2017
Hospital Readmissions among Commercially Insured and Medicare Advantage Beneficiaries with Diabetes and the Impact of Severe Hypoglycemic and Hyperglycemic Events
McCoy RG, Lipska KJ, Herrin J, Jeffery MM, Krumholz HM, Shah ND. Hospital Readmissions among Commercially Insured and Medicare Advantage Beneficiaries with Diabetes and the Impact of Severe Hypoglycemic and Hyperglycemic Events. Journal Of General Internal Medicine 2017, 32: 1097-1105. PMID: 28685482, PMCID: PMC5602759, DOI: 10.1007/s11606-017-4095-x.Peer-Reviewed Original ResearchConceptsDiabetes Complications Severity IndexSevere dysglycemiaIndex hospitalizationMedicare Advantage beneficiariesRisk factorsBetter care transitionsComplications Severity IndexPost-discharge managementIndependent risk factorYounger patient ageOptumLabs Data WarehouseStrong risk factorYears of ageBackgroundHospital readmissionsDesignRetrospective analysisCause readmissionUnplanned readmissionPatient agePrior hospitalizationReadmission ratesYounger patientsHeart failureHospital readmissionSevere hypoglycemiaDiabetes complications
2016
Polypharmacy in the Aging Patient: A Review of Glycemic Control in Older Adults With Type 2 Diabetes
Lipska KJ, Krumholz H, Soones T, Lee SJ. Polypharmacy in the Aging Patient: A Review of Glycemic Control in Older Adults With Type 2 Diabetes. JAMA 2016, 315: 1034-1045. PMID: 26954412, PMCID: PMC4823136, DOI: 10.1001/jama.2016.0299.BooksConceptsRandomized clinical trialsIntensive glycemic controlGlycemic controlClinical trialsOlder adultsMicrovascular outcomesTreatment burdenPatient preferencesMost RCTsLarge randomized clinical trialsType 2 diabetes mellitusMajor macrovascular eventsStandard glycemic controlOptimal glycemic controlLower treatment burdenSurrogate end pointsHigh-quality evidenceType 2 diabetesLikelihood of benefitMajority of adultsGlycemic treatmentMacrovascular eventsDiabetes mellitusPatient factorsAging Patient
2014
National Trends in US Hospital Admissions for Hyperglycemia and Hypoglycemia Among Medicare Beneficiaries, 1999 to 2011
Lipska KJ, Ross JS, Wang Y, Inzucchi SE, Minges K, Karter AJ, Huang ES, Desai MM, Gill TM, Krumholz HM. National Trends in US Hospital Admissions for Hyperglycemia and Hypoglycemia Among Medicare Beneficiaries, 1999 to 2011. JAMA Internal Medicine 2014, 174: 1116-1124. PMID: 24838229, PMCID: PMC4152370, DOI: 10.1001/jamainternmed.2014.1824.Peer-Reviewed Original Research
2013
HbA1c and Risk of Severe Hypoglycemia in Type 2 Diabetes
Lipska KJ, Warton EM, Huang ES, Moffet HH, Inzucchi SE, Krumholz HM, Karter AJ. HbA1c and Risk of Severe Hypoglycemia in Type 2 Diabetes. Diabetes Care 2013, 36: 3535-3542. PMID: 23900589, PMCID: PMC3816866, DOI: 10.2337/dc13-0610.Peer-Reviewed Original ResearchConceptsSevere hypoglycemiaType 2 diabetesRelative riskGlycemic controlSelf-reported severe hypoglycemiaType 2 diabetic patientsGlucose-lowering therapyPoor glycemic controlRate of hypoglycemiaPotential effect modifiersIntegrated healthcare systemYears of ageEligible survey respondentsPoisson regression modelsDiabetes durationDiabetes medicationsDiabetic patientsClinical variablesDiabetes StudyNormal glycemiaMain exposureEffect modifiersHypoglycemiaType 2Patients
2010
Discontinuation of Antihyperglycemic Therapy and Clinical Outcomes After Acute Myocardial Infarction in Older Patients With Diabetes
Lipska KJ, Wang Y, Kosiborod M, Masoudi FA, Havranek EP, Krumholz HM, Inzucchi SE. Discontinuation of Antihyperglycemic Therapy and Clinical Outcomes After Acute Myocardial Infarction in Older Patients With Diabetes. Circulation Cardiovascular Quality And Outcomes 2010, 3: 236-242. PMID: 20354220, DOI: 10.1161/circoutcomes.109.887620.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionAntihyperglycemic therapyAntihyperglycemic agentsOlder patientsMyocardial infarctionMortality rateMultivariable Cox proportional hazards modelsCox proportional hazards modelFrequency of discontinuationGlucose-lowering agentsGlucose-lowering therapyInclusion/exclusion criteriaProportional hazards modelYear of dischargeHigh mortality rateDiabetic regimenFirst rehospitalizationReadmission ratesSecondary outcomesHeart failurePrimary outcomeClinical outcomesMultivariable analysisRetrospective studyIndependent association
2009
Intensive glucose control and cardiovascular outcomes
Lipska K, Inzucchi, Kosiborod M, Krumholz H. Intensive glucose control and cardiovascular outcomes. The Lancet 2009, 374: 522-523. PMID: 19683633, DOI: 10.1016/s0140-6736(09)61479-3.Peer-Reviewed Original ResearchRelationship Between Spontaneous and Iatrogenic Hypoglycemia and Mortality in Patients Hospitalized With Acute Myocardial Infarction
Kosiborod M, Inzucchi SE, Goyal A, Krumholz HM, Masoudi FA, Xiao L, Spertus JA. Relationship Between Spontaneous and Iatrogenic Hypoglycemia and Mortality in Patients Hospitalized With Acute Myocardial Infarction. JAMA 2009, 301: 1556-1564. PMID: 19366775, DOI: 10.1001/jama.2009.496.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionInsulin therapyHospital mortalityIatrogenic hypoglycemiaHypoglycemic eventsMyocardial infarctionMortality riskGlucose-lowering therapyRetrospective cohort studySubgroup of patientsHigher mortality riskLogistic regression modelsMore comorbiditiesSubsequent hospitalizationMultivariable adjustmentCohort studyGlucose loweringGlucose controlEpisodic hypoglycemiaMAIN OUTCOMEHypoglycemiaPatientsHealth FactsHigh mortalityTherapyElevated Admission Glucose and Mortality in Elderly Patients Hospitalized With Heart Failure
Kosiborod M, Inzucchi SE, Spertus JA, Wang Y, Masoudi FA, Havranek EP, Krumholz HM. Elevated Admission Glucose and Mortality in Elderly Patients Hospitalized With Heart Failure. Circulation 2009, 119: 1899-1907. PMID: 19332465, DOI: 10.1161/circulationaha.108.821843.Peer-Reviewed Original ResearchConceptsHeart failureAdmission glucoseElderly patientsDiabetes mellitusAdverse outcomesMultivariable Cox regression modelsAdmission glucose levelsElevated admission glucoseAcute myocardial infarctionCox regression modelCause mortalityMultivariable adjustmentEntire cohortGlucose controlMyocardial infarctionCardiovascular conditionsGlucose levelsLarge cohortElevated glucoseRepresentative cohortPatientsSignificant associationMortalityCohortMellitusGlucose Normalization and Outcomes in Patients With Acute Myocardial Infarction
Kosiborod M, Inzucchi SE, Krumholz HM, Masoudi FA, Goyal A, Xiao L, Jones PG, Fiske S, Spertus JA. Glucose Normalization and Outcomes in Patients With Acute Myocardial Infarction. JAMA Internal Medicine 2009, 169: 438-446. PMID: 19273773, DOI: 10.1001/archinternmed.2008.593.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionInsulin therapyMyocardial infarctionGlucose levelsGlucose normalizationBetter survivalElevated blood glucose levelsMultivariable logistic regression modelPropensity-matched analysisMean glucose levelBlood glucose levelsPropensity-matching methodsLow glucose levelsLogistic regression modelsHospital mortalityMultivariable adjustmentImproved survivalHyperglycemic patientsSpontaneous resolutionPatientsMortality rateUS hospitalsAdmissionInfarctionTherapy
2008
Glucometrics in Patients Hospitalized With Acute Myocardial Infarction
Kosiborod M, Inzucchi SE, Krumholz HM, Xiao L, Jones PG, Fiske S, Masoudi FA, Marso SP, Spertus JA. Glucometrics in Patients Hospitalized With Acute Myocardial Infarction. Circulation 2008, 117: 1018-1027. PMID: 18268145, DOI: 10.1161/circulationaha.107.740498.Peer-Reviewed Original Research
2005
Admission Glucose and Mortality in Elderly Patients Hospitalized With Acute Myocardial Infarction
Kosiborod M, Rathore SS, Inzucchi SE, Masoudi FA, Wang Y, Havranek EP, Krumholz HM. Admission Glucose and Mortality in Elderly Patients Hospitalized With Acute Myocardial Infarction. Circulation 2005, 111: 3078-3086. PMID: 15939812, DOI: 10.1161/circulationaha.104.517839.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionGlucose levelsHigh glucose levelsMyocardial infarctionAdmission glucoseElderly patientsHyperglycemic patientsMortality riskElderly acute myocardial infarction patientsAcute myocardial infarction patientsAdmission glucose levelsMyocardial infarction patientsSimilar glucose levelsGreater mortality riskNondiabetic patientsMultivariable adjustmentDiabetic patientsInfarction patientsElevated glucosePatientsDiabetesGreater riskInfarctionMortality resultsMortality