2019
Digoxin Use and Associated Adverse Events Among Older Adults
Angraal S, Nuti SV, Masoudi FA, Freeman JV, Murugiah K, Shah ND, Desai NR, Ranasinghe I, Wang Y, Krumholz HM. Digoxin Use and Associated Adverse Events Among Older Adults. The American Journal Of Medicine 2019, 132: 1191-1198. PMID: 31077654, DOI: 10.1016/j.amjmed.2019.04.022.Peer-Reviewed Original ResearchConceptsRate of hospitalizationDigoxin useDigoxin toxicityNational Prescription AuditMedicare feeService beneficiariesDigoxin prescriptionAssociated adverse eventsAdverse eventsCohort studyAdverse outcomesSecondary diagnosisNational cohortPrescription auditPrescription trendsClinical guidelinesHospitalizationMortality rateClinical practiceOlder adultsSubsequent outcomesOutcomesToxicityPrescriptionNational-level trends
2004
Renal Function, Digoxin Therapy, and Heart Failure Outcomes: Evidence from the Digoxin Intervention Group Trial
SHLIPAK MG, SMITH GL, RATHORE SS, MASSIE BM, KRUMHOLZ HM. Renal Function, Digoxin Therapy, and Heart Failure Outcomes: Evidence from the Digoxin Intervention Group Trial. Journal Of The American Society Of Nephrology 2004, 15: 2195-2203. PMID: 15284305, DOI: 10.1097/01.asn.0000135121.81744.75.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateHeart failure outcomesEffect of digoxinRenal functionHeart failureRenal dysfunctionGroup trialsMortality riskLow glomerular filtration rateLevel of GFRFailure outcomesSystolic heart failureHeart failure survivalLower mortality hazardDigoxin efficacyCause mortalityDigoxin therapyCommon complicationClinical outcomesFiltration rateGFR 60Failure survivalSimilar riskMortality hazardStable outpatients
2003
Digoxin therapy for heart failure: safe for women?
Rathore SS, Krumholz HM. Digoxin therapy for heart failure: safe for women? Journal Of Cardiovascular Medicine 2003, 4: 148-51. PMID: 12784740.Peer-Reviewed Original ResearchAssociation of Serum Digoxin Concentration and Outcomes in Patients With Heart Failure
Rathore SS, Curtis JP, Wang Y, Bristow MR, Krumholz HM. Association of Serum Digoxin Concentration and Outcomes in Patients With Heart Failure. JAMA 2003, 289: 871-878. PMID: 12588271, DOI: 10.1001/jama.289.7.871.Peer-Reviewed Original ResearchConceptsSerum digoxin concentrationHigh serum digoxin concentrationsLeft ventricular ejection fractionVentricular ejection fractionHeart failureMortality rateDIG trialDigoxin therapyEjection fractionDigoxin concentrationsDepressed left ventricular systolic functionDigitalis Investigation Group trialHigher absolute mortality rateLeft ventricular systolic functionOverall mortality benefitVentricular systolic functionCause mortality ratesAbsolute mortality ratesLower mortality rateCause mortalityMultivariable adjustmentMortality benefitSystolic functionClinical outcomesSerum concentrations
2002
Sex-Based Differences in the Effect of Digoxin for the Treatment of Heart Failure
Rathore SS, Wang Y, Krumholz HM. Sex-Based Differences in the Effect of Digoxin for the Treatment of Heart Failure. New England Journal Of Medicine 2002, 347: 1403-1411. PMID: 12409542, DOI: 10.1056/nejmoa021266.Peer-Reviewed Original ResearchConceptsEffect of digoxinDepressed left ventricular systolic functionLeft ventricular systolic functionVentricular systolic functionSex-based differencesRate of deathDigoxin therapyHeart failureSystolic functionMultivariable Cox proportional hazards modelsDigitalis Investigation Group (DIG) studyDigitalis Investigation Group trialCox proportional hazards modelHeart failure variesPrimary end pointRisk of deathProportional hazards modelMantel-Haenszel testOverall mortalityTherapy differsEpidemiologic featuresMultivariable analysisClinical variablesSubgroup analysisGroup trials
2000
Evaluating Quality of Care for Patients With Heart Failure
Krumholz H, Baker D, Ashton C, Dunbar S, Friesinger G, Havranek E, Hlatky M, Konstam M, Ordin D, Pina I, Pitt B, Spertus J. Evaluating Quality of Care for Patients With Heart Failure. Circulation 2000, 101: e122-40. PMID: 10736303, DOI: 10.1161/01.cir.101.12.e122.Peer-Reviewed Original ResearchAdrenergic beta-AntagonistsAgedAngiotensin-Converting Enzyme InhibitorsAnticoagulantsAspirinAtrial FibrillationData CollectionDigoxinExercise TherapyFee-for-Service PlansHeart FailureHumansInformation ServicesLength of StayOutcome and Process Assessment, Health CarePatient Education as TopicPractice Guidelines as TopicPractice Patterns, Physicians'Quality of Health CareReferral and ConsultationStroke VolumeUnited StatesVentricular Dysfunction, Left