2023
Foundation models for generalist medical artificial intelligence
Moor M, Banerjee O, Abad Z, Krumholz H, Leskovec J, Topol E, Rajpurkar P. Foundation models for generalist medical artificial intelligence. Nature 2023, 616: 259-265. PMID: 37045921, DOI: 10.1038/s41586-023-05881-4.Peer-Reviewed Original ResearchMeSH KeywordsArtificial IntelligenceDatasets as TopicDiagnostic ImagingElectronic Health RecordsGenomicsHumansMedicineUnsupervised Machine LearningConceptsMedical AILarge medical datasetsMedical artificial intelligenceArtificial intelligence modelsImage annotationMedical datasetsArtificial intelligenceElectronic health recordsAI devicesIntelligence modelsTraining datasetDiverse datasetsExpressive outputHealth recordsRapid developmentDatasetFree-text explanationsMedical modalitiesNew paradigmMedical textsAITechnical capabilitiesDiverse setNewfound capabilitiesCapability
2019
Evaluation of the Patient Request Process for Radiology Imaging in U.S. Hospitals.
Lye CT, Krumholz HM, Eckroate JE, Daniel JG, deBronkart D, Mann MK, Hsiao AL, Forman HP. Evaluation of the Patient Request Process for Radiology Imaging in U.S. Hospitals. Radiology 2019, 292: 409-413. PMID: 31184560, DOI: 10.1148/radiol.2019190473.Peer-Reviewed Original ResearchMeSH KeywordsCross-Sectional StudiesDiagnostic ImagingHospitalsHumansPatient Access to RecordsRadiologyUnited States
2018
Impact of Cost Display on Ordering Patterns for Hospital Laboratory and Imaging Services
Silvestri MT, Xu X, Long T, Bongiovanni T, Bernstein SL, Chaudhry SI, Silvestri JI, Stolar M, Greene EJ, Dziura JD, Gross CP, Krumholz HM. Impact of Cost Display on Ordering Patterns for Hospital Laboratory and Imaging Services. Journal Of General Internal Medicine 2018, 33: 1268-1275. PMID: 29845468, PMCID: PMC6082197, DOI: 10.1007/s11606-018-4495-6.Peer-Reviewed Original ResearchConceptsDecreased oddsImaging ordersHealth care servicesBehalf of patientsKey ResultsDuringMain MeasuresOutcomesParticipantsAll patientsHospital encountersImaging testsObservation encountersCare servicesHealth servicesMedicare fee scheduleHealth systemImaging costsDecreased numberHospital laboratoriesLab ordersStudy periodHospital labPatients
2014
Hospital Variation in the Use of Noninvasive Cardiac Imaging and Its Association With Downstream Testing, Interventions, and Outcomes
Safavi KC, Li SX, Dharmarajan K, Venkatesh AK, Strait KM, Lin H, Lowe TJ, Fazel R, Nallamothu BK, Krumholz HM. Hospital Variation in the Use of Noninvasive Cardiac Imaging and Its Association With Downstream Testing, Interventions, and Outcomes. JAMA Internal Medicine 2014, 174: 546-553. PMID: 24515551, PMCID: PMC5459406, DOI: 10.1001/jamainternmed.2013.14407.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNoninvasive cardiac imagingDownstream testingReadmission ratesRevascularization proceduresCardiac imagingHospital variationCardiac ischemiaProportion of patientsNoninvasive imagingLower readmission ratesPrincipal discharge diagnosisCross-sectional studyCardiac biomarker testsQ4 hospitalsChest discomfortCoronary angiographyCoronary diseaseDischarge diagnosisCoronary angiogramEmergency departmentMyocardial infarctionSame hospitalCurrent guidelinesInpatient wards
2011
Use of Medical Imaging Procedures With Ionizing Radiation in Children: A Population-Based Study
Dorfman AL, Fazel R, Einstein AJ, Applegate KE, Krumholz HM, Wang Y, Christodoulou E, Chen J, Sanchez R, Nallamothu BK. Use of Medical Imaging Procedures With Ionizing Radiation in Children: A Population-Based Study. JAMA Pediatrics 2011, 165: 458-464. PMID: 21199972, PMCID: PMC3686496, DOI: 10.1001/archpediatrics.2010.270.Peer-Reviewed Original ResearchConceptsDiagnostic imaging proceduresTomographic scanImaging proceduresRetrospective cohort analysisPopulation-based ratesPediatric populationPlain radiographyCohort analysisHigh dosesMedical diagnostic imaging proceduresStudy periodAppropriate useChildrenHigh rateMedical imaging proceduresScansFrequent useHealth care marketUS health care marketYearsPatientsInfantsPopulationCare marketUnitedHealthcare
2010
2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease: Executive Summary
Hiratzka L, Bakris G, Beckman J, Bersin R, Carr V, Casey D, Eagle K, Hermann L, Isselbacher E, Kazerooni E, Kouchoukos N, Lytle B, Milewicz D, Reich D, Sen S, Shinn J, Svensson L, Williams D, Jacobs A, Smith S, Anderson J, Adams C, Buller C, Creager M, Ettinger S, Guyton R, Halperin J, Hunt S, Krumholz H, Kushner F, Lytle B, Nishimura R, Page R, Riegel B, Stevenson W, Tarkington L, Yancy C. 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease: Executive Summary. Catheterization And Cardiovascular Interventions 2010, 76: e43-e86. PMID: 20687249, DOI: 10.1002/ccd.22537.Peer-Reviewed Original ResearchCumulative Exposure to Ionizing Radiation From Diagnostic and Therapeutic Cardiac Imaging Procedures A Population-Based Analysis
Chen J, Einstein AJ, Fazel R, Krumholz HM, Wang Y, Ross JS, Ting HH, Shah ND, Nasir K, Nallamothu BK. Cumulative Exposure to Ionizing Radiation From Diagnostic and Therapeutic Cardiac Imaging Procedures A Population-Based Analysis. Journal Of The American College Of Cardiology 2010, 56: 702-711. PMID: 20619569, PMCID: PMC2952402, DOI: 10.1016/j.jacc.2010.05.014.Peer-Reviewed Original ResearchConceptsCardiac imaging proceduresCumulative effective doseMSv/yearEffective dosesImaging proceduresEffective doseRadiation exposureGeneral populationAnnual population-based ratesCardiac computed tomography (CT) studiesMean cumulative effective dosePopulation-based annual rateCumulative effective dosesMyocardial perfusion imagingComputed tomography studyPopulation-based ratesSubstantial radiation exposureCumulative dosesAdministrative claimsMyocardial perfusionPhysician's officeCumulative exposurePerfusion imagingPatientsTomography study
2006
Achieving Quality in Cardiovascular Imaging Proceedings From the American College of Cardiology–Duke University Medical Center Think Tank on Quality in Cardiovascular Imaging
Douglas P, Iskandrian AE, Krumholz HM, Gillam L, Hendel R, Jollis J, Peterson E, Douglas P, Chen J, Gillam L, Hendel R, Jollis J, Iskandrian A, Krumholz H, Masoudi F, Mohler E, McNamara R, Patel M, Peterson E, Spertus J. Achieving Quality in Cardiovascular Imaging Proceedings From the American College of Cardiology–Duke University Medical Center Think Tank on Quality in Cardiovascular Imaging. Journal Of The American College Of Cardiology 2006, 48: 2141-2151. PMID: 17113004, DOI: 10.1016/j.jacc.2006.06.076.Peer-Reviewed Original ResearchHow useful is computed tomography for screening for coronary artery disease? Screening for coronary artery disease with electron-beam computed tomography is not useful.
Chen J, Krumholz HM. How useful is computed tomography for screening for coronary artery disease? Screening for coronary artery disease with electron-beam computed tomography is not useful. Circulation 2006, 113: 125-46; discussion 125-46. PMID: 16400723.Peer-Reviewed Original Research