2023
Characterisation of internal tremors and vibration symptoms
Massey D, Sawano M, Baker A, Güthe D, Güthe N, Shidlovsky S, Fisher L, Grady C, Caraballo C, Zhou T, Sharma R, Krumholz H. Characterisation of internal tremors and vibration symptoms. BMJ Open 2023, 13: e077389. PMID: 38154880, PMCID: PMC10759066, DOI: 10.1136/bmjopen-2023-077389.Peer-Reviewed Original Research
2022
Association of Neighborhood-Level Material Deprivation With Atrial Fibrillation Care in a Single-Payer Health Care System: A Population-Based Cohort Study
Abdel-Qadir H, Akioyamen LE, Fang J, Pang A, Ha ACT, Jackevicius CA, Alter DA, Austin PC, Atzema CL, Bhatia RS, Booth GL, Johnston S, Dhalla I, Kapral MK, Krumholz HM, McNaughton CD, Roifman I, Tu K, Udell JA, Wijeysundera HC, Ko DT, Schull MJ, Lee DS. Association of Neighborhood-Level Material Deprivation With Atrial Fibrillation Care in a Single-Payer Health Care System: A Population-Based Cohort Study. Circulation 2022, 146: 159-171. PMID: 35678171, PMCID: PMC9287095, DOI: 10.1161/circulationaha.122.058949.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnticoagulantsAtrial FibrillationCohort StudiesDelivery of Health CareFemaleHeart FailureHemorrhageHumansMaleOntarioRisk FactorsStrokeConceptsYears of ageCohort studyUniversal health careAF-related adverse eventsNeighbourhood-level material deprivationPopulation-based cohort studyPrimary care physician visitsCause-specific hazards regressionRhythm control interventionsHigh cardiovascular disease burdenCardiovascular disease burdenHealth careAtrial fibrillation careNeighborhood material deprivationSingle-payer health care systemMaterial deprivation quintileAtrial fibrillation diagnosisHealth care systemNoncardiovascular comorbiditiesAdverse eventsHeart failurePhysician visitsHazards regressionAdverse outcomesDeprivation quintileClinical decision support in cardiovascular medicine
Lu Y, Melnick ER, Krumholz HM. Clinical decision support in cardiovascular medicine. The BMJ 2022, 377: e059818. PMID: 35613721, DOI: 10.1136/bmj-2020-059818.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseCardiovascular careEffectiveness of CDSRisk factor modificationClinical decision support toolQuality of careClinical decision supportClinical outcomesFactor modificationHealth information technologyClinical practicePatient careDiseaseCardiovascular medicineCDS effectivenessCareEffectiveness of deliveryMissed opportunityTreatmentFailureProper evidenceHealthcare processesMedicineEvidencePreventionPerspectives of Patients About Artificial Intelligence in Health Care
Khullar D, Casalino LP, Qian Y, Lu Y, Krumholz HM, Aneja S. Perspectives of Patients About Artificial Intelligence in Health Care. JAMA Network Open 2022, 5: e2210309. PMID: 35507346, PMCID: PMC9069257, DOI: 10.1001/jamanetworkopen.2022.10309.Peer-Reviewed Original Research12th Korea Healthcare Congress 2021; 김치국부터 마시지 말라; The Time for Digital Health is Almost Here
Krumholz HM. 12th Korea Healthcare Congress 2021; 김치국부터 마시지 말라; The Time for Digital Health is Almost Here. Yonsei Medical Journal 2022, 63: 493-498. PMID: 35512753, PMCID: PMC9086693, DOI: 10.3349/ymj.2022.63.5.493.Peer-Reviewed Original Research
2021
Trends in Differences in Health Status and Health Care Access and Affordability by Race and Ethnicity in the United States, 1999-2018
Mahajan S, Caraballo C, Lu Y, Valero-Elizondo J, Massey D, Annapureddy AR, Roy B, Riley C, Murugiah K, Onuma O, Nunez-Smith M, Forman HP, Nasir K, Herrin J, Krumholz HM. Trends in Differences in Health Status and Health Care Access and Affordability by Race and Ethnicity in the United States, 1999-2018. JAMA 2021, 326: 637-648. PMID: 34402830, PMCID: PMC8371573, DOI: 10.1001/jama.2021.9907.Peer-Reviewed Original ResearchConceptsHealth care accessFair health statusSelf-reported health statusCare accessHealth statusWhite individualsEthnic differencesLatino/HispanicNational Health Interview Survey dataSerial cross-sectional studySelf-reported functional limitationsBlack individualsHealth Interview Survey dataLow incomeCross-sectional studyCross-sectional survey studyInterview Survey dataSelf-reported raceSelf-report measuresMAIN OUTCOMEUS adultsFunctional limitationsPercentage of peopleSignificant decreaseAdults
2020
From Reactivity to Proactivity On the Path to Pre-Empting Heart Failure Hospitalizations ∗
Desai NR, Krumholz HM. From Reactivity to Proactivity On the Path to Pre-Empting Heart Failure Hospitalizations ∗. JACC Heart Failure 2020, 8: 1035-1037. PMID: 33189634, DOI: 10.1016/j.jchf.2020.09.007.Peer-Reviewed Original ResearchGeographic Variation in Process and Outcomes of Care for Patients With Acute Myocardial Infarction in China From 2001 to 2015
Zhong Q, Gao Y, Zheng X, Chen J, Masoudi FA, Lu Y, Feng Y, Hu S, Zhang Q, Huang C, Wang Y, Krumholz HM, Li X, Zhou Y. Geographic Variation in Process and Outcomes of Care for Patients With Acute Myocardial Infarction in China From 2001 to 2015. JAMA Network Open 2020, 3: e2021182. PMID: 33095248, PMCID: PMC7584924, DOI: 10.1001/jamanetworkopen.2020.21182.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionProcess of careHospital mortalityMyocardial infarctionOdds ratioAngiotensin receptor blockersCross-sectional studyOutcomes of careReceptor blockersReperfusion therapyPatient characteristicsTherapy useCare measuresPatient hospitalizationIdeal patientOutcome measuresMAIN OUTCOMEΒ-blockersAMI managementPatientsEnzyme inhibitorsSignificant geographic variationMortalityCareHospitalizationIdentifying characteristics of high-poverty counties in the United States with high well-being: an observational cross-sectional study
Arora A, Spatz ES, Herrin J, Riley C, Roy B, Rula EY, Kell KP, Krumholz HM. Identifying characteristics of high-poverty counties in the United States with high well-being: an observational cross-sectional study. BMJ Open 2020, 10: e035645. PMID: 32948545, PMCID: PMC7500307, DOI: 10.1136/bmjopen-2019-035645.Peer-Reviewed Original ResearchMeSH KeywordsCross-Sectional StudiesDelivery of Health CareHumansPovertyPrevalenceSmokingUnited StatesConceptsObservational cross-sectional studyCross-sectional studyHigh-poverty countiesMean wellRobert Wood Johnson Foundation County Health RankingsLow physical inactivityPrimary care physiciansCounty characteristicsPopulation health modelCounty Health RankingsPreventable hospital staysHospital stayCare physiciansHighest quartilePhysical inactivityHigh percentageMAIN OUTCOMELow prevalenceIndex scoreHeavy drinkersHealth RankingsPopulation-level measuresHealth modelBottom quintileTop quintileAgile Health Care Analytics: Enabling Real-Time Disease Surveillance With a Computational Health Platform
Schulz WL, Durant T, Torre CJ, Hsiao AL, Krumholz HM. Agile Health Care Analytics: Enabling Real-Time Disease Surveillance With a Computational Health Platform. Journal Of Medical Internet Research 2020, 22: e18707. PMID: 32442130, PMCID: PMC7257473, DOI: 10.2196/18707.Peer-Reviewed Original ResearchConceptsReal-time dataHealth information technologyReal-world dataHealth platformInformation technologyCombination of technologiesReal timeSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Timely informationRespiratory syndrome coronavirus 2PlatformRespiratory tract infectionsSyndrome coronavirus 2Health care systemTract infectionsCoronavirus disease (COVID-19) outbreakIncident casesCoronavirus 2Novel applicationTechnologyAnalyticsHealth systemCare systemSpecific pathogens
2019
Tapping Into Underutilized Healthcare Data in Clinical Research
Mori M, Schulz WL, Geirsson A, Krumholz HM. Tapping Into Underutilized Healthcare Data in Clinical Research. Annals Of Surgery 2019, Publish Ahead of Print: &na;. PMID: 30998537, DOI: 10.1097/sla.0000000000003329.Peer-Reviewed Original ResearchPost Hospital Syndrome: Is the Stress of Hospitalization Causing Harm?
Caraballo C, Dharmarajan K, Krumholz HM. Post Hospital Syndrome: Is the Stress of Hospitalization Causing Harm? Revista Española De Cardiología (English Edition) 2019, 72: 896-898. PMID: 31175070, DOI: 10.1016/j.rec.2019.04.010.BooksHealth Care and Precision Medicine Research: Analysis of a Scalable Data Science Platform
McPadden J, Durant TJ, Bunch DR, Coppi A, Price N, Rodgerson K, Torre CJ, Byron W, Hsiao AL, Krumholz HM, Schulz WL. Health Care and Precision Medicine Research: Analysis of a Scalable Data Science Platform. Journal Of Medical Internet Research 2019, 21: e13043. PMID: 30964441, PMCID: PMC6477571, DOI: 10.2196/13043.Peer-Reviewed Original ResearchConceptsData science platformOpen source technologiesHealth care dataSource technologiesModern big data platformScience platformData management approachTraditional computer systemsBig data workloadsBig data platformBig data sourcesReal-time datasetBiomedical research dataHealth care applicationsData-driven researchPatient monitoringScalable analyticsApache StormData lakeData workloadsAnalytics platformData acquisition workflowContinuous patient monitoringUse casesData platform
2018
Will research preprints improve healthcare for patients?
Krumholz HM, Ross JS, Otto CM. Will research preprints improve healthcare for patients? The BMJ 2018, 362: k3628. PMID: 30249719, DOI: 10.1136/bmj.k3628.Commentaries, Editorials and Letters
2017
Priorities for Cardiovascular Outcomes Research
Khazanie P, Krumholz HM, Kiefe CI, Kressin NR, Wells B, Wang TY, Peterson ED. Priorities for Cardiovascular Outcomes Research. Circulation Cardiovascular Quality And Outcomes 2017, 10: e001967. PMID: 28710296, PMCID: PMC7811766, DOI: 10.1161/circoutcomes.115.001967.Peer-Reviewed Original ResearchCardiologyCost-Benefit AnalysisDelivery of Health CareHealth Care CostsHealth Services ResearchHumansInterdisciplinary CommunicationNational Heart, Lung, and Blood Institute (U.S.)Organizational ObjectivesOutcome Assessment, Health CarePatient-Centered CarePublic-Private Sector PartnershipsStakeholder ParticipationTranslational Research, BiomedicalUnited States
2016
Healthcare Disparities Affecting Americans in the US Territories: A Century-Old Dilemma
Rodríguez-Vilá O, Nuti SV, Krumholz HM. Healthcare Disparities Affecting Americans in the US Territories: A Century-Old Dilemma. The American Journal Of Medicine 2016, 130: e39-e42. PMID: 27593609, DOI: 10.1016/j.amjmed.2016.07.036.Peer-Reviewed Original Research
2015
Insurance and Prehospital Delay in Patients ≤55 Years With Acute Myocardial Infarction
Chen SI, Wang Y, Dreyer R, Strait KM, Spatz ES, Xu X, Smolderen KG, Desai NR, Lorenze NP, Lichtman JH, Spertus JA, D'Onofrio G, Bueno H, Masoudi FA, Krumholz HM. Insurance and Prehospital Delay in Patients ≤55 Years With Acute Myocardial Infarction. The American Journal Of Cardiology 2015, 116: 1827-1832. PMID: 26541907, PMCID: PMC5323057, DOI: 10.1016/j.amjcard.2015.09.018.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrehospital delayInsurance statusMyocardial infarctionSpanish patientsGender differencesHealth care systemUS patientsProspective studyUS cohortUS womenPatientsUniversal insuranceCare systemWomenSignificant gender differencesInfarctionMenInsurance groupsHoursStatusAssociationLarge proportionDifferencesCohortAchieving best outcomes for patients with cardiovascular disease in China by enhancing the quality of medical care and establishing a learning health-care system
Jiang L, Krumholz HM, Li X, Li J, Hu S. Achieving best outcomes for patients with cardiovascular disease in China by enhancing the quality of medical care and establishing a learning health-care system. The Lancet 2015, 386: 1493-1505. PMID: 26466053, PMCID: PMC5323019, DOI: 10.1016/s0140-6736(15)00343-8.Peer-Reviewed Original Research
2014
Patient and Caregiver Viewpoints
Mann MK, Krumholz HM. Patient and Caregiver Viewpoints. Circulation Cardiovascular Quality And Outcomes 2014, 7: 634. PMID: 25097211, DOI: 10.1161/circoutcomes.114.001248.Peer-Reviewed Original ResearchBig Data And New Knowledge In Medicine: The Thinking, Training, And Tools Needed For A Learning Health System
Krumholz HM. Big Data And New Knowledge In Medicine: The Thinking, Training, And Tools Needed For A Learning Health System. Health Affairs 2014, 33: 1163-1170. PMID: 25006142, PMCID: PMC5459394, DOI: 10.1377/hlthaff.2014.0053.Peer-Reviewed Original ResearchMeSH KeywordsData Interpretation, StatisticalData MiningDatasets as TopicDecision Support Systems, ClinicalDelivery of Health CareHumansLearningMedical InformaticsThinkingConceptsBig dataNext-generation analyticsHealth care dataNew data sourcesAdvanced analyticsData meaningLearning health systemInformation needsUnmet information needsMassive quantitiesData sourcesHealth policy makersComplexity of patientsAnalyticsLearning health care systemComparative effectiveness researchHealth care systemPopulation health researchKnowledge generationCare dataHealth systemPatientsCare systemEffectiveness researchHealth research