2023
Detection of Left Ventricular Systolic Dysfunction From Electrocardiographic Images
Sangha V, Nargesi A, Dhingra L, Khunte A, Mortazavi B, Ribeiro A, Banina E, Adeola O, Garg N, Brandt C, Miller E, Ribeiro A, Velazquez E, Giatti L, Barreto S, Foppa M, Yuan N, Ouyang D, Krumholz H, Khera R. Detection of Left Ventricular Systolic Dysfunction From Electrocardiographic Images. Circulation 2023, 148: 765-777. PMID: 37489538, PMCID: PMC10982757, DOI: 10.1161/circulationaha.122.062646.Peer-Reviewed Original ResearchMeSH KeywordsAdultElectrocardiographyHumansLongitudinal StudiesProspective StudiesVentricular Dysfunction, LeftVentricular Function, LeftConceptsLV systolic dysfunctionYale-New Haven HospitalVentricular systolic dysfunctionSystolic dysfunctionLV ejection fractionBrazilian Longitudinal StudyNew Haven HospitalEjection fractionCardiology clinicRegional hospitalLeft ventricular systolic dysfunctionCedars-Sinai Medical CenterAdult Health (ELSA-Brasil) cohort
2022
Hospital Variation of Spironolactone Use in Patients Hospitalized for Heart Failure in China—The China PEACE Retrospective Heart Failure Study
Yu Y, Guan W, Masoudi FA, Wang B, He G, Spertus JA, Lu Y, Krumholz HM, Li J. Hospital Variation of Spironolactone Use in Patients Hospitalized for Heart Failure in China—The China PEACE Retrospective Heart Failure Study. Journal Of The American Heart Association 2022, 11: e026300. PMID: 36172964, PMCID: PMC9673705, DOI: 10.1161/jaha.122.026300.Peer-Reviewed Original ResearchMeSH KeywordsHeart FailureHospitalsHumansMineralocorticoid Receptor AntagonistsRetrospective StudiesSpironolactoneStroke VolumeTreatment OutcomeUnited StatesVentricular Function, LeftConceptsSpironolactone prescriptionSpironolactone useHeart failureMedian odds ratioIdeal patientAldosterone antagonistsHospital variationMedian rateReduced ejection fractionUse of spironolactoneMultivariable linear regression modelsHeart Failure StudyEjection fractionHospital characteristicsOdds ratioRepresentative cohortPatientsHospitalChinese hospitalsInappropriate usePrescriptionSpironolactoneSelect individualsAntagonistHigh rate
2019
Characteristics, Management, and Outcomes of Patients Hospitalized for Heart Failure in China: The China PEACE Retrospective Heart Failure Study
Yu Y, Gupta A, Wu C, Masoudi FA, Du X, Zhang J, Krumholz HM, Li J, Group T. Characteristics, Management, and Outcomes of Patients Hospitalized for Heart Failure in China: The China PEACE Retrospective Heart Failure Study. Journal Of The American Heart Association 2019, 8: e012884. PMID: 31431117, PMCID: PMC6755852, DOI: 10.1161/jaha.119.012884.Peer-Reviewed Original ResearchConceptsHeart failureHF careSignificant healthcare resource utilizationBackground Heart failureGuideline-recommended medicationsLower inpatient mortalityAcute heart failureOutcomes of patientsHealthcare resource utilizationLower prescription ratesMedical record abstractionHeart Failure StudyTraditional Chinese medicineHospital mortalityConclusions PatientsInpatient mortalityPatient characteristicsTreatment withdrawalEjection fractionMedian agePrescription ratesRecord abstractionMedian lengthBiomarker testingInpatient setting
2012
2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease
Fihn SD, Gardin JM, Abrams J, Berra K, Blankenship JC, Dallas AP, Douglas PS, Foody JM, Gerber TC, Hinderliter AL, King SB, Kligfield PD, Krumholz HM, Kwong RY, Lim MJ, Linderbaum JA, Mack MJ, Munger MA, Prager RL, Sabik JF, Shaw LJ, Sikkema JD, Smith CR, Smith SC, Spertus JA, Williams SV. 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease. Circulation 2012, 126: 3097-3137. PMID: 23166210, DOI: 10.1161/cir.0b013e3182776f83.Peer-Reviewed Original Research
2009
Elevated Admission Glucose and Mortality in Elderly Patients Hospitalized With Heart Failure
Kosiborod M, Inzucchi SE, Spertus JA, Wang Y, Masoudi FA, Havranek EP, Krumholz HM. Elevated Admission Glucose and Mortality in Elderly Patients Hospitalized With Heart Failure. Circulation 2009, 119: 1899-1907. PMID: 19332465, DOI: 10.1161/circulationaha.108.821843.Peer-Reviewed Original ResearchConceptsHeart failureAdmission glucoseElderly patientsDiabetes mellitusAdverse outcomesMultivariable Cox regression modelsAdmission glucose levelsElevated admission glucoseAcute myocardial infarctionCox regression modelCause mortalityMultivariable adjustmentEntire cohortGlucose controlMyocardial infarctionCardiovascular conditionsGlucose levelsLarge cohortElevated glucoseRepresentative cohortPatientsSignificant associationMortalityCohortMellitus
2008
ACC/AHA 2008 Performance Measures for Adults With ST-Elevation and Non–ST-Elevation Myocardial Infarction A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures (Writing Committee to Develop Performance Measures for ST-Elevation and Non–ST-Elevation Myocardial Infarction) Developed in Collaboration With the American Academy of Family Physicians and American College of Emergency Physicians Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation, Society for Cardiovascular Angiography and Interventions, and Society of Hospital Medicine
Krumholz HM, Anderson JL, Bachelder BL, Fesmire FM, Fihn SD, Foody JM, Ho PM, Kosiborod MN, Masoudi FA, Nallamothu BK. ACC/AHA 2008 Performance Measures for Adults With ST-Elevation and Non–ST-Elevation Myocardial Infarction A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures (Writing Committee to Develop Performance Measures for ST-Elevation and Non–ST-Elevation Myocardial Infarction) Developed in Collaboration With the American Academy of Family Physicians and American College of Emergency Physicians Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation, Society for Cardiovascular Angiography and Interventions, and Society of Hospital Medicine. Journal Of The American College Of Cardiology 2008, 52: 2046-2099. PMID: 19056000, DOI: 10.1016/j.jacc.2008.10.012.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAmerican Heart AssociationAngioplasty, Balloon, CoronaryAnticoagulantsHeart Conduction SystemHumansMyocardial InfarctionOutcome Assessment, Health CarePlatelet Aggregation InhibitorsQuality of Health CareSocieties, MedicalStroke VolumeUnited StatesVentricular Function, Left
2004
Provider and Hospital Characteristics Associated With Geographic Variation in the Evaluation and Management of Elderly Patients With Heart Failure
Havranek EP, Wolfe P, Masoudi FA, Rathore SS, Krumholz HM, Ordin DL. Provider and Hospital Characteristics Associated With Geographic Variation in the Evaluation and Management of Elderly Patients With Heart Failure. JAMA Internal Medicine 2004, 164: 1186-1191. PMID: 15197043, DOI: 10.1001/archinte.164.11.1186.Peer-Reviewed Original ResearchConceptsGuideline-based careElderly patientsHeart failureHospital characteristicsPatient factorsEnzyme inhibitorsSmall-area geographic variationLeft ventricular ejection fractionEnzyme inhibitor prescriptionHeart failure variesHeart failure careVentricular ejection fractionHospital referral regionsHigh-quality health careMedical school affiliationInhibitor prescriptionEjection fractionPatient characteristicsSmall area variationUnadjusted ratesMedicare patientsReferral regionsAppropriate prescriptionPatientsCharacteristics of providers
2003
Race, Quality of Care, and Outcomes of Elderly Patients Hospitalized With Heart Failure
Rathore SS, Foody JM, Wang Y, Smith GL, Herrin J, Masoudi FA, Wolfe P, Havranek EP, Ordin DL, Krumholz HM. Race, Quality of Care, and Outcomes of Elderly Patients Hospitalized With Heart Failure. JAMA 2003, 289: 2517-2524. PMID: 12759323, DOI: 10.1001/jama.289.19.2517.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngiotensin-Converting Enzyme InhibitorsBlack or African AmericanFee-for-Service PlansFemaleHeart FailureHospitalsHumansMaleMedicareMultivariate AnalysisOutcome Assessment, Health CarePatient ReadmissionQuality of Health CareRetrospective StudiesSurvival AnalysisUnited StatesVentricular Function, LeftWhite PeopleConceptsLeft ventricular ejection fractionQuality of careACE inhibitor useWhite patientsBlack patientsHeart failureYear of dischargeACE inhibitorsMultivariable adjustmentInhibitor useLVEF assessmentCrude rateMedicare beneficiariesMortality rateAngiotensin receptor blocker useNational Heart Failure ProjectBlack Medicare patientsHeart Failure ProjectPrescription of angiotensinReceptor blocker useHigh rateVentricular ejection fractionYear of admissionHigher crude ratesService Medicare beneficiariesGender, age, and heart failure with preserved left ventricular systolic function
Masoudi FA, Havranek EP, Smith G, Fish RH, Steiner JF, Ordin DL, Krumholz HM. Gender, age, and heart failure with preserved left ventricular systolic function. Journal Of The American College Of Cardiology 2003, 41: 217-223. PMID: 12535812, DOI: 10.1016/s0735-1097(02)02696-7.Peer-Reviewed Original ResearchMeSH KeywordsAgedCross-Sectional StudiesFemaleHeart FailureHumansLogistic ModelsMaleMedicareOdds RatioRetrospective StudiesRisk FactorsSex FactorsUnited StatesVentricular Function, LeftConceptsLeft ventricular systolic functionImpaired left ventricular systolic functionVentricular systolic functionHeart failureSystolic functionFemale genderDiagnosis of HFMedical chart abstractionCoronary artery diseasePrincipal discharge diagnosisAge 65 yearsMultivariable logistic regressionCross-sectional studyPotential confounding variablesRenal insufficiencyChart abstractionClinical characteristicsElderly patientsArtery diseaseEjection fractionPulmonary diseasePatient factorsAtrial fibrillationDischarge diagnosisPotential confounders
2001
Quality of Medical Care and Excess Mortality in Older Patients With Mental Disorders
Druss BG, Bradford WD, Rosenheck RA, Radford MJ, Krumholz HM. Quality of Medical Care and Excess Mortality in Older Patients With Mental Disorders. JAMA Psychiatry 2001, 58: 565-572. PMID: 11386985, DOI: 10.1001/archpsyc.58.6.565.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAge FactorsAgedAngiotensin-Converting Enzyme InhibitorsAspirinCluster AnalysisCohort StudiesComorbidityFemaleFollow-Up StudiesHospitalizationHumansMaleMedicareMental DisordersMyocardial InfarctionMyocardial ReperfusionProportional Hazards ModelsQuality of Health CareRisk FactorsSmoking CessationVentricular Function, LeftConceptsExcess mortalityMajor affective disordersMyocardial infarctionMedical careMental disordersAffective disordersMedicare patients 65 yearsCardiac risk factorsPatients 65 yearsAcute myocardial infarctionProportional hazards modelPatient's medical carePotential confounding factorsCessation counselingOlder patientsVentricular functionAdmission characteristicsNational cohortHospital characteristicsRisk factorsHazards modelEnzyme inhibitorsConfounding factorsMortalityInfarction
2000
Association of patients’ perception of health status and exercise electrocardiogram, myocardial perfusion imaging, and ventricular function measures
Mattera J, de Leon C, Wackers F, Williams C, Wang Y, Krumholz H. Association of patients’ perception of health status and exercise electrocardiogram, myocardial perfusion imaging, and ventricular function measures. American Heart Journal 2000, 140: 409-418. PMID: 10966538, DOI: 10.1067/mhj.2000.108518.Peer-Reviewed Original ResearchConceptsGeneral health perceptionHealth-related qualityPhysical functioningHealth perceptionMyocardial perfusion imagingHealth statusExercise testingPerfusion imagingMedical Outcomes Study Short Form SurveyPatients' health-related qualityShort Form SurveyAssociation of patientGeneral health statusImportant outcome measureSuccess of treatmentConsecutive patientsSF-36Metabolic equivalentsNoninvasive testingExercise testPatient outcomesIndividual patientsOutcome measuresForm SurveyPatient's viewpoint
1997
Quality of Care for Elderly Patients Hospitalized With Heart Failure
Krumholz HM, Wang Y, Parent EM, Mockalis J, Petrillo M, Radford MJ. Quality of Care for Elderly Patients Hospitalized With Heart Failure. JAMA Internal Medicine 1997, 157: 2242-2247. PMID: 9343001, DOI: 10.1001/archinte.1997.00440400092011.Peer-Reviewed Original ResearchConceptsHeart failureQuality of careEnzyme inhibitorsElderly patientsClinical practiceResearch Clinical Practice GuidelinesLeft ventricular ejection fractionLeft ventricular systolic functionRetrospective medical record reviewAngiotensin-converting enzyme inhibitorSevere aortic stenosisPercentage of patientsVentricular systolic functionMedical record reviewVentricular ejection fractionClinical practice guidelinesPrincipal discharge diagnosisAcute care hospitalsActual clinical practiceHealth care policyChart reviewSystolic functionAortic stenosisAppropriate patientsCare hospitalValidation of a clinical prediction rule for left ventricular ejection fraction after myocardial infarction in patients ≥ 65 years old
Krumholz H, Howes C, Murillo J, Vaccarino L, Radford M, Ellerbeck E. Validation of a clinical prediction rule for left ventricular ejection fraction after myocardial infarction in patients ≥ 65 years old. The American Journal Of Cardiology 1997, 80: 11-15. PMID: 9205012, DOI: 10.1016/s0002-9149(97)00299-3.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCohort StudiesConnecticutEchocardiographyElectrocardiographyFemaleHumansMaleMedicareMultivariate AnalysisMyocardial InfarctionPilot ProjectsPredictive Value of TestsRetrospective StudiesRisk FactorsStroke VolumeTreatment OutcomeUnited StatesVentricular Function, LeftConceptsLeft ventricular ejection fractionAcute myocardial infarctionClinical prediction ruleVentricular ejection fractionPositive predictive valuePrediction ruleElderly patientsEjection fractionMyocardial infarctionExclusion criteriaPredictive valueEligible elderly patientsRetrospective chart reviewConnecticut cohortChest painBypass surgeryChart reviewDiabetes mellitusMedicare patientsPatientsPilot studyMultivariate modelInfarctionElectrocardiogram interpretationOriginal studyDeterminants of Appropriate Use of Angiotensin-Converting Enzyme Inhibitors After Acute Myocardial Infarction in Persons ≥65 Years of Age
Krumholz H, Vaccarino V, Ellerbeck E, Kiefe C, Hennen J, Kresowik T, Gold J, Jencks S, Radford M. Determinants of Appropriate Use of Angiotensin-Converting Enzyme Inhibitors After Acute Myocardial Infarction in Persons ≥65 Years of Age. The American Journal Of Cardiology 1997, 79: 581-586. PMID: 9068512, DOI: 10.1016/s0002-9149(96)00819-3.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlabamaAngiotensin-Converting Enzyme InhibitorsConnecticutContraindicationsControlled Clinical Trials as TopicDecision MakingDiabetes ComplicationsDiureticsDrug PrescriptionsDrug UtilizationFemaleFollow-Up StudiesHeart FailureHospitalizationHumansIowaMaleMedicaidMultivariate AnalysisMyocardial InfarctionPatient DischargeRetrospective StudiesStroke VolumeTachycardia, VentricularUnited StatesVentricular Function, LeftWisconsinConceptsAcute myocardial infarctionACE inhibitorsMyocardial infarctionDischarge medicationsVentricular functionEnzyme inhibitorsLeft ventricular ejection fractionAngiotensin-converting enzyme inhibitorAngiotensin converting enzyme (ACE) inhibitorsVentricular Enlargement (SAVE) trialCongestive heart failureVentricular ejection fractionYears of ageEligible patientsPatient characteristicsAppropriate patientsDiabetes mellitusEjection fractionHeart failureLoop diureticsMultivariable analysisVentricular tachycardiaIdeal patientObservational studyPatientsReporting ejection fraction after myocardial infarction: an opportunity for quality improvement in echocardiography.
Goldberg DJ, Radford MJ, Krumholz HM. Reporting ejection fraction after myocardial infarction: an opportunity for quality improvement in echocardiography. Connecticut Medicine 1997, 61: 143-5. PMID: 9097485.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overEchocardiographyFemaleHumansMaleMedical RecordsMyocardial InfarctionVentricular Function, LeftConceptsMyocardial infarctionEjection fractionLeft ventricular ejection fractionVentricular ejection fractionVentricular systolic functionAcute myocardial infarctionCare of patientsSystolic functionVentricular functionEchocardiography studyMedicare beneficiariesInfarctionEchocardiographyReportPrincipal findings
1996
Comparison and reproducibility of visual echocardiographic and quantitative radionyclide left ventricular ejection fractions
van Royen N, Jaffe C, Krumholz H, Johnson K, Lynch P, Natale D, Atkinson P, Demon P, Wackers F. Comparison and reproducibility of visual echocardiographic and quantitative radionyclide left ventricular ejection fractions. The American Journal Of Cardiology 1996, 77: 843-850. PMID: 8623737, DOI: 10.1016/s0002-9149(97)89179-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overEchocardiographyFemaleGated Blood-Pool ImagingHumansMaleMiddle AgedReproducibility of ResultsRetrospective StudiesStroke VolumeVentricular Function, LeftConceptsEquilibrium radionuclide angiographyVentricular ejection fractionEjection fractionRadionuclide angiographyEchocardiographic LVEFEquilibrium radionuclideRadionuclide LVEFClinical relevanceLeft ventricular ejection fractionCorrelation of LVEFDetermination of LVEFPatient management decisionsPotential clinical relevanceRelevant differencesInter-observer reproducibilityStable patientsLV functionLimits of agreementLVEFIndividual patientsRepeat assessmentEchocardiographyAngiographyBlinded analysisRepeat analysis
1992
Selection of patients for coronary angiography and coronary revascularization early after myocardial infarction: is there evidence for a gender bias?
Krumholz HM, Douglas PS, Lauer MS, Pasternak RC. Selection of patients for coronary angiography and coronary revascularization early after myocardial infarction: is there evidence for a gender bias? Annals Of Internal Medicine 1992, 116: 785-90. PMID: 1567092, DOI: 10.7326/0003-4819-116-10-785.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAngioplasty, Balloon, CoronaryCardiac CatheterizationCoronary AngiographyCoronary Artery BypassFemaleHospitalizationHumansMaleMiddle AgedMyocardial InfarctionMyocardial RevascularizationOdds RatioPatient SelectionPrejudiceReferral and ConsultationRetrospective StudiesSeverity of Illness IndexSex FactorsVentricular Function, LeftConceptsCoronary artery diseaseSelection of patientsMyocardial infarctionCoronary angiographyArtery diseaseCoronary artery bypass graft surgeryArtery bypass graft surgeryCoronary artery bypass surgerySevere coronary artery diseasePercutaneous transluminal coronary angioplastyCreatine kinase MB fractionTertiary care teaching hospitalThree-vessel diseaseTwo-vessel diseaseArtery bypass surgeryBypass graft surgeryLeft main stenosisRetrospective cohort studyTransluminal coronary angioplastyPrincipal discharge diagnosisAcute myocardial infarctionAbnormal ejection fractionAge-adjusted ratesTherapeutic cardiovascular proceduresCoronary revascularization