2015
Frequency and Effects of Excess Dosing of Anticoagulants in Patients ≤55 Years With Acute Myocardial Infarction Who Underwent Percutaneous Coronary Intervention (from the VIRGO Study)
Gupta A, Chui P, Zhou S, Spertus JA, Geda M, Lorenze N, Lee I, Onofrio G, Lichtman JH, Alexander KP, Krumholz HM, Curtis JP. Frequency and Effects of Excess Dosing of Anticoagulants in Patients ≤55 Years With Acute Myocardial Infarction Who Underwent Percutaneous Coronary Intervention (from the VIRGO Study). The American Journal Of Cardiology 2015, 116: 1-7. PMID: 25937348, PMCID: PMC4466069, DOI: 10.1016/j.amjcard.2015.03.032.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAngioplasty, Balloon, CoronaryAnticoagulantsAntithrombinsBody Mass IndexCohort StudiesFemaleHemorrhageHeparinHirudinsHumansMaleMiddle AgedMyocardial InfarctionPeptide FragmentsPercutaneous Coronary InterventionPlatelet Glycoprotein GPIIb-IIIa ComplexPrevalenceRecombinant ProteinsRisk AssessmentRisk FactorsSex DistributionTreatment OutcomeUnited StatesConceptsPercutaneous coronary interventionGlycoprotein IIb/IIIa inhibitorsIIb/IIIa inhibitorsExcess dosingAcute myocardial infarctionCoronary interventionMultivariable analysisMyocardial infarctionUnderwent Percutaneous Coronary InterventionLower body weightOlder patientsYounger patientsUnfractionated heparinMedical recordsUnivariate analysisAnticoagulant agentsAnticoagulant drugsBody weightPatientsDosingYounger ageLogistic regressionYoung womenAnticoagulantsGender-based differences
2014
Relation between door-to-balloon times and mortality after primary percutaneous coronary intervention over time: a retrospective study
Nallamothu BK, Normand SL, Wang Y, Hofer TP, Brush JE, Messenger JC, Bradley EH, Rumsfeld JS, Krumholz HM. Relation between door-to-balloon times and mortality after primary percutaneous coronary intervention over time: a retrospective study. The Lancet 2014, 385: 1114-1122. PMID: 25467573, PMCID: PMC4409657, DOI: 10.1016/s0140-6736(14)61932-2.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionD2B timePercutaneous coronary interventionPopulation of patientsHospital mortalityBalloon timeCoronary interventionRetrospective studyMortality riskNational Cardiovascular Data Registry CathPCI RegistryST-elevation myocardial infarction (STEMI) patientsProcedural factorsStudy periodMyocardial infarction patientsNumber of patientsShorter D2B timesPopulation levelSecular trendsAbsence of associationPrimary PCICathPCI RegistryElderly patientsBlood InstituteEntire cohortAverage door
2012
Physical function and independence 1 year after myocardial infarction: Observations from the Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status registry
Dodson JA, Arnold SV, Reid KJ, Gill TM, Rich MW, Masoudi FA, Spertus JA, Krumholz HM, Alexander KP. Physical function and independence 1 year after myocardial infarction: Observations from the Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status registry. American Heart Journal 2012, 163: 790-796. PMID: 22607856, PMCID: PMC3359897, DOI: 10.1016/j.ahj.2012.02.024.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAge FactorsAgedAngioplasty, Balloon, CoronaryAttitude to HealthCardiac CatheterizationCoronary AngiographyDepressionElectrocardiographyFemaleFollow-Up StudiesHealth SurveysHumansIncidenceIndependent LivingMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPhysical FitnessPoisson DistributionPredictive Value of TestsQuality of LifeRegistriesRisk AssessmentSickness Impact ProfileSurveys and QuestionnairesSurvivorsTime FactorsTranslational Research, BiomedicalConceptsAcute myocardial infarctionPhysical function declineFunction declinePhysical functionMyocardial infarctionHealth statusEuroQol-5DUninsured statusTime of AMIShort Form-12 Physical Component ScoreIndependence lossEnd-stage renal diseasePost-acute myocardial infarctionCardiac rehabilitation referralPhysical component scorePatients' health statusQuality of lifePoisson regression modelsTRIUMPH registryRehabilitation referralRenal diseaseNonwhite raceFemale sexRisk factorsUnmarried status
2011
Use and Effectiveness of Intra-Aortic Balloon Pumps Among Patients Undergoing High Risk Percutaneous Coronary Intervention
Curtis JP, Rathore SS, Wang Y, Chen J, Nallamothu BK, Krumholz HM. Use and Effectiveness of Intra-Aortic Balloon Pumps Among Patients Undergoing High Risk Percutaneous Coronary Intervention. Circulation Cardiovascular Quality And Outcomes 2011, 5: 21-30. PMID: 22147887, PMCID: PMC3801197, DOI: 10.1161/circoutcomes.110.960385.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCoronary DiseaseFemaleHemodynamicsHospital MortalityHumansIntra-Aortic Balloon PumpingMaleMiddle AgedRegistriesRiskTreatment OutcomeConceptsHigh-risk percutaneous coronary interventionIntra-aortic balloon pumpPercutaneous coronary interventionHospital quartilesHospital mortalityIABP useCoronary interventionBalloon pumpHospital characteristicsST-segment elevation myocardial infarctionDepressed left ventricular functionHigh-risk PCI patientsSegment elevation myocardial infarctionElevation myocardial infarctionLeft ventricular functionHierarchical logistic regression modelsLogistic regression modelsIABP usageCardiogenic shockPCI patientsCathPCI RegistryHemodynamic supportVentricular functionHospital variationMultivariable analysis30-Day Readmission for Patients Undergoing Percutaneous Coronary Interventions in New York State
Hannan EL, Zhong Y, Krumholz H, Walford G, Holmes DR, Stamato NJ, Jacobs AK, Venditti FJ, Sharma S, King SB. 30-Day Readmission for Patients Undergoing Percutaneous Coronary Interventions in New York State. JACC Cardiovascular Interventions 2011, 4: 1335-1342. PMID: 22192374, DOI: 10.1016/j.jcin.2011.08.013.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionReadmission ratesUnique risk factorsRisk factorsCoronary interventionAdministrative databasesComplications of PCIPre-procedural risk factorsRepeat percutaneous coronary interventionChronic ischemic heart diseaseOverall readmission rateHigher readmission ratesIschemic heart diseaseLength of stayNew York State patientsRecognition of patientsDiagnostic risk factorsCost-effectiveness standpointPCI patientsPCI registryChest painHeart failureHospital readmissionHeart diseasePrincipal diagnosisNational Performance on Door-In to Door-Out Time Among Patients Transferred for Primary Percutaneous Coronary Intervention
Herrin J, Miller LE, Turkmani DF, Nsa W, Drye EE, Bernheim SM, Ling SM, Rapp MT, Han LF, Bratzler DW, Bradley EH, Nallamothu BK, Ting HH, Krumholz HM. National Performance on Door-In to Door-Out Time Among Patients Transferred for Primary Percutaneous Coronary Intervention. JAMA Internal Medicine 2011, 171: 1879-1886. PMID: 22123793, PMCID: PMC4312661, DOI: 10.1001/archinternmed.2011.481.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionDIDO timeCoronary interventionST-segment elevation acute myocardial infarctionMixed-effects multivariable modelElevation acute myocardial infarctionPrimary percutaneous coronary interventionMedian DIDO timeAcute myocardial infarctionFibrinolytic therapyPatient characteristicsMultivariable analysisEmergency departmentMyocardial infarctionHospital characteristicsMultivariable modelPatientsRural hospitalsHospitalMedicaid ServicesAge categoriesInterventionAfrican AmericansMinutesTreatment timeFactors Associated With 30-Day Readmission Rates After Percutaneous Coronary Intervention
Khawaja FJ, Shah ND, Lennon RJ, Slusser JP, Alkatib AA, Rihal CS, Gersh BJ, Montori VM, Holmes DR, Bell MR, Curtis JP, Krumholz HM, Ting HH. Factors Associated With 30-Day Readmission Rates After Percutaneous Coronary Intervention. JAMA Internal Medicine 2011, 172: 112-117. PMID: 22123752, PMCID: PMC3688066, DOI: 10.1001/archinternmed.2011.569.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngina, UnstableAngioplasty, Balloon, CoronaryCoronary Artery BypassEducational StatusFemaleFollow-Up StudiesHeart FailureHumansIschemic Attack, TransientKidney DiseasesLength of StayMaleMedicareMultivariate AnalysisMyocardial InfarctionNeoplasm MetastasisPatient ReadmissionPeptic UlcerProportional Hazards ModelsPulmonary Disease, Chronic ObstructiveRegistriesSex FactorsStrokeUnited StatesConceptsPercutaneous coronary interventionThirty-day readmissionReadmission ratesCoronary interventionHigh riskChronic obstructive pulmonary diseaseThirty-day readmission ratesCox proportional hazards modelMultivariate logistic regression modelTransient ischemic attackCongestive heart failureObstructive pulmonary diseasePeptic ulcer diseaseSevere renal diseaseAcute myocardial infarctionLength of stayMain outcome measuresProportional hazards modelSaint Mary's HospitalLogistic regression modelsIschemic attackTime-dependent covariatesUnstable anginaCerebrovascular accidentHeart failureImprovements in Door-to-Balloon Time in the United States, 2005 to 2010
Krumholz HM, Herrin J, Miller LE, Drye EE, Ling SM, Han LF, Rapp MT, Bradley EH, Nallamothu BK, Nsa W, Bratzler DW, Curtis JP. Improvements in Door-to-Balloon Time in the United States, 2005 to 2010. Circulation 2011, 124: 1038-1045. PMID: 21859971, PMCID: PMC3598634, DOI: 10.1161/circulationaha.111.044107.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryFemaleHealth Care SurveysHospitalsHumansMaleMiddle AgedMyocardial InfarctionRegistriesTime FactorsUnited StatesYoung AdultConceptsPrimary percutaneous coronary interventionPercutaneous coronary interventionBalloon timeCoronary interventionMedian timeST-segment elevation myocardial infarctionHigher median timeCharacteristics of patientsPercentage of patientsTimeliness of treatmentYears of ageRegistry studyMyocardial infarctionInpatient measuresPatientsHospital groupMedicaid ServicesCalendar yearInterventionMinutesMedianGroupYearsPercentageInfarctionAssociation of Door-In to Door-Out Time With Reperfusion Delays and Outcomes Among Patients Transferred for Primary Percutaneous Coronary Intervention
Wang TY, Nallamothu BK, Krumholz HM, Li S, Roe MT, Jollis JG, Jacobs AK, Holmes DR, Peterson ED, Ting HH. Association of Door-In to Door-Out Time With Reperfusion Delays and Outcomes Among Patients Transferred for Primary Percutaneous Coronary Intervention. JAMA 2011, 305: 2540-2547. PMID: 21693742, DOI: 10.1001/jama.2011.862.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCohort StudiesFemaleHospital MortalityHumansMaleMiddle AgedMyocardial InfarctionMyocardial ReperfusionOdds RatioPatient AdmissionPatient DischargePatient TransferQuality Indicators, Health CareReferral and ConsultationRetrospective StudiesTime FactorsTreatment OutcomeUnited StatesConceptsPrimary percutaneous coronary interventionST-elevation myocardial infarctionPrimary PCIPercutaneous coronary interventionDIDO timeHospital mortalityDTB timeCoronary interventionReperfusion delayFirst hospital presentationMedian DIDO timeOff-hour presentationSTEMI referral hospitalsClinical performance measuresHospital presentationAbsolute contraindicationBalloon timeRetrospective cohortReferral hospitalInterhospital transferACTION RegistryFemale sexMyocardial infarctionFirst HospitalPatient outcomes
2010
Putting Ad Hoc PCI on Pause
Nallamothu BK, Krumholz HM. Putting Ad Hoc PCI on Pause. JAMA 2010, 304: 2059-2060. PMID: 21063016, DOI: 10.1001/jama.2010.1509.Peer-Reviewed Original ResearchAngioplasty, Balloon, CoronaryCardiac CatheterizationCardiologyCoronary Artery DiseaseDecision MakingHumansPresident's Page: National Quality Initiatives Put ACC's Mission Into Action
Brindis R, Krumholz HM. President's Page: National Quality Initiatives Put ACC's Mission Into Action. Journal Of The American College Of Cardiology 2010, 56: 1260-1262. PMID: 20883935, DOI: 10.1016/j.jacc.2010.09.004.Peer-Reviewed Original ResearchCumulative Exposure to Ionizing Radiation From Diagnostic and Therapeutic Cardiac Imaging Procedures A Population-Based Analysis
Chen J, Einstein AJ, Fazel R, Krumholz HM, Wang Y, Ross JS, Ting HH, Shah ND, Nasir K, Nallamothu BK. Cumulative Exposure to Ionizing Radiation From Diagnostic and Therapeutic Cardiac Imaging Procedures A Population-Based Analysis. Journal Of The American College Of Cardiology 2010, 56: 702-711. PMID: 20619569, PMCID: PMC2952402, DOI: 10.1016/j.jacc.2010.05.014.Peer-Reviewed Original ResearchConceptsCardiac imaging proceduresCumulative effective doseMSv/yearEffective dosesImaging proceduresEffective doseRadiation exposureGeneral populationAnnual population-based ratesCardiac computed tomography (CT) studiesMean cumulative effective dosePopulation-based annual rateCumulative effective dosesMyocardial perfusion imagingComputed tomography studyPopulation-based ratesSubstantial radiation exposureCumulative dosesAdministrative claimsMyocardial perfusionPhysician's officeCumulative exposurePerfusion imagingPatientsTomography studyTrends in Race-Based Differences in Door-to-Balloon Times
Curtis JP, Herrin J, Bratzler DW, Bradley EH, Krumholz HM. Trends in Race-Based Differences in Door-to-Balloon Times. JAMA Internal Medicine 2010, 170: 992-993. PMID: 20548015, DOI: 10.1001/archinternmed.2010.165.Peer-Reviewed Original ResearchOpportunities to Improve Care for Patients With ST-Segment Elevation Myocardial Infarction: Focusing on How to Deliver the Care
Krumholz H. Opportunities to Improve Care for Patients With ST-Segment Elevation Myocardial Infarction: Focusing on How to Deliver the Care. Revista Española De Cardiología 2010, 63: 509-512. PMID: 20450842, DOI: 10.1016/s1885-5857(10)70110-9.Peer-Reviewed Original ResearchOportunidades para mejorar la asistencia de los pacientes con infarto de miocardio con elevación del segmento ST: enfoque sobre la prestación de la asistencia
Krumholz HM. Oportunidades para mejorar la asistencia de los pacientes con infarto de miocardio con elevación del segmento ST: enfoque sobre la prestación de la asistencia. Revista Española De Cardiología 2010, 63: 509-512. DOI: 10.1016/s0300-8932(10)70110-x.Peer-Reviewed Original ResearchMeta-analysis: effects of percutaneous coronary intervention versus medical therapy on angina relief.
Wijeysundera HC, Nallamothu BK, Krumholz HM, Tu JV, Ko DT. Meta-analysis: effects of percutaneous coronary intervention versus medical therapy on angina relief. Annals Of Internal Medicine 2010, 152: 370-9. PMID: 20231568, DOI: 10.7326/0003-4819-152-6-201003160-00007.Peer-Reviewed Original ResearchMeSH KeywordsAngina PectorisAngioplasty, Balloon, CoronaryCoronary DiseaseDrug-Eluting StentsHumansMyocardial InfarctionRegression AnalysisConceptsPercutaneous coronary interventionStable coronary artery diseaseEvidence-based medicationsCoronary artery diseaseMedical therapyAngina reliefCoronary interventionArtery diseaseIndependent reviewersTrials of PCIIncremental benefitRecent myocardial infarctionInclusion of patientsEvidence-based therapiesStudy-level dataDrug-eluting stentsRandom-effects modelMeta-regression analysisLong-term usePatient characteristicsCochrane LibraryContemporary trialsLanguage restrictionsMyocardial infarctionRecent trialsDifferences in Patient Survival After Acute Myocardial Infarction by Hospital Capability of Performing Percutaneous Coronary Intervention: Implications for Regionalization
Chen J, Krumholz HM, Wang Y, Curtis JP, Rathore SS, Ross JS, Normand SL, Schreiner GC, Mulvey G, Nallamothu BK. Differences in Patient Survival After Acute Myocardial Infarction by Hospital Capability of Performing Percutaneous Coronary Intervention: Implications for Regionalization. JAMA Internal Medicine 2010, 170: 433-439. PMID: 20212179, PMCID: PMC2900156, DOI: 10.1001/archinternmed.2009.538.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, Balloon, CoronaryFemaleHospitalsHumansMaleMyocardial InfarctionOutcome Assessment, Health CareRegistriesSurvival AnalysisSurvival RateTreatment OutcomeUnited StatesConceptsRisk-standardized mortality ratesNon-PCI hospitalsPercutaneous coronary interventionAcute myocardial infarctionHospital referral regionsPCI hospitalsHealth care regionCoronary interventionAMI patientsMyocardial infarctionCare regionLower risk-standardized mortality ratesSame hospital referral regionService beneficiaries 65 yearsBeneficiaries 65 yearsMagnitude of benefitPatient survivalAMI careReferral regionsOutcome differencesMedicare feeMortality rateHospitalHospital capabilitiesInfarction
2009
Choice of Reperfusion Strategy at Hospitals With Primary Percutaneous Coronary Intervention
Fazel R, Krumholz HM, Bates ER, French WJ, Frederick PD, Nallamothu BK. Choice of Reperfusion Strategy at Hospitals With Primary Percutaneous Coronary Intervention. Circulation 2009, 120: 2455-2461. PMID: 19948977, DOI: 10.1161/circulationaha.109.860544.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, Balloon, CoronaryChoice BehaviorCohort StudiesFemaleHospitalsHumansMaleMiddle AgedMyocardial InfarctionMyocardial ReperfusionRegistriesUnited StatesConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionPCI-capable hospitalsPrimary PCIReperfusion strategyMyocardial infarctionFibrinolytic therapySystem-related factorsPercutaneous coronary intervention capabilityMyocardial Infarction (TIMI) risk scorePrimary percutaneous coronary interventionHierarchical multivariable logistic regressionKey clinical factorsPercutaneous coronary interventionMultivariable logistic regressionPCI useCardiogenic shockCoronary interventionClinical factorsIntracranial hemorrhageNonwhite raceNational registryRisk factorsAdvanced ageFemale genderNational Efforts to Improve Door-to-Balloon Time Results From the Door-to-Balloon Alliance
Bradley EH, Nallamothu BK, Herrin J, Ting HH, Stern AF, Nembhard IM, Yuan CT, Green JC, Kline-Rogers E, Wang Y, Curtis JP, Webster TR, Masoudi FA, Fonarow GC, Brush JE, Krumholz HM. National Efforts to Improve Door-to-Balloon Time Results From the Door-to-Balloon Alliance. Journal Of The American College Of Cardiology 2009, 54: 2423-2429. PMID: 20082933, DOI: 10.1016/j.jacc.2009.11.003.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryEfficiency, OrganizationalHospitalizationHospitalsHumansLongitudinal StudiesMyocardial InfarctionQuality Assurance, Health CareRegistriesTime FactorsUnited StatesConceptsST-segment elevation myocardial infarctionD2B AllianceBalloon (D2B) AllianceHospital presentationD2B timeNational Cardiovascular Data Registry CathPCI RegistryPrimary percutaneous coronary interventionElevation myocardial infarctionPercutaneous coronary interventionLikelihood of patientsCathPCI RegistryCoronary interventionBalloon timeMyocardial infarctionAmerican CollegePatientsHospitalLongitudinal studyNational Quality CampaignOne-halfPresentationMinNational effortsInfarctionRegistry2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update) A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
Kushner FG, Hand M, Smith SC, King SB, Anderson JL, Antman EM, Bailey SR, Bates ER, Blankenship JC, Casey DE, Green LA, Hochman JS, Jacobs AK, Krumholz HM, Morrison DA, Ornato JP, Pearle DL, Peterson ED, Sloan MA, Whitlow PL, Williams DO. 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update) A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Journal Of The American College Of Cardiology 2009, 54: 2205-2241. PMID: 19942100, DOI: 10.1016/j.jacc.2009.10.015.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryElectrocardiographyHumansMyocardial InfarctionPractice Guidelines as TopicSocieties, MedicalUnited StatesConceptsACC/AHA/SCAI GuidelineAmerican Heart Association Task ForceACC/AHA guidelinesST-elevation myocardial infarctionPercutaneous coronary interventionCardiology Foundation/American Heart Association Task ForceManagement of patientsAHA guidelinesCoronary interventionMyocardial infarctionFocused updatePractice guidelinesAmerican CollegeTask ForceGuidelinesInfarctionPatients