2022
Depression and Perceived Stress After Spontaneous Coronary Artery Dissection and Comparison With Other Acute Myocardial Infarction (the VIRGO Experience)
Murugiah K, Chen L, Dreyer RP, Bouras G, Safdar B, Lu Y, Spatz ES, Gupta A, Khera R, Ng VG, Bueno H, Tweet MS, Spertus JA, Hayes SN, Lansky A, Krumholz HM. Depression and Perceived Stress After Spontaneous Coronary Artery Dissection and Comparison With Other Acute Myocardial Infarction (the VIRGO Experience). The American Journal Of Cardiology 2022, 173: 33-38. PMID: 35365290, PMCID: PMC9133198, DOI: 10.1016/j.amjcard.2022.03.005.Peer-Reviewed Original ResearchMeSH KeywordsCoronary AngiographyCoronary Vessel AnomaliesCoronary VesselsDepressionFemaleHumansMyocardial InfarctionRisk FactorsStress, PsychologicalVascular DiseasesConceptsSpontaneous coronary artery dissectionPatient Health Questionnaire-9Coronary artery dissectionPSS-14 scoreArtery dissectionBaseline PHQ-9 scoreAcute myocardial infarction patientsCardiovascular risk factorsPHQ-9 scoresAcute myocardial infarctionMyocardial infarction patientsYears of agePerceived Stress Scale scoresStress Scale scoresLinear mixed-effects analysisSCAD casesVIRGO StudyQuestionnaire-9Infarction patientsMixed-effects analysisMyocardial infarctionSubgroup analysisRisk factorsRoutine screeningClinical acuity
2019
Post Hospital Syndrome: Is the Stress of Hospitalization Causing Harm?
Caraballo C, Dharmarajan K, Krumholz HM. Post Hospital Syndrome: Is the Stress of Hospitalization Causing Harm? Revista Española De Cardiología (English Edition) 2019, 72: 896-898. PMID: 31175070, DOI: 10.1016/j.rec.2019.04.010.Books
2018
Is Posthospital Syndrome a Result of Hospitalization-Induced Allostatic Overload?
Goldwater DS, Dharmarajan K, McEwan BS, Krumholz HM. Is Posthospital Syndrome a Result of Hospitalization-Induced Allostatic Overload? Journal Of Hospital Medicine 2018, 13 PMID: 29813141, DOI: 10.12788/jhm.2986.Peer-Reviewed Original ResearchConceptsPosthospital syndromeAllostatic overloadAutonomic nervous systemMultiple organ systemsHospital dischargeInflammatory markersAdverse eventsHospital readmissionAdrenal axisAdverse outcomesPlausible etiologyPathophysiologic consequencesElevated riskNervous systemNarrative reviewOrgan systemsEnhanced vulnerabilityElevated levelsHospital environmentTraditional hospital environmentSyndromeMaladaptive statesOverloadOutcomesPossible mechanism
2017
Perceived Stress After Acute Myocardial Infarction
Xu X, Bao H, Strait KM, Edmondson DE, Davidson KW, Beltrame JF, Bueno H, Lin H, Dreyer RP, Brush JE, Spertus JA, Lichtman JH, D'Onofrio G, Krumholz HM. Perceived Stress After Acute Myocardial Infarction. Psychosomatic Medicine 2017, 79: 50-58. PMID: 27984507, PMCID: PMC5459399, DOI: 10.1097/psy.0000000000000429.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsFemaleFollow-Up StudiesHumansMaleMiddle AgedMyocardial InfarctionSex FactorsStress, PsychologicalYoung AdultConceptsAcute myocardial infarctionPSS-14 scoreMiddle-aged patientsPatient characteristicsMyocardial infarctionSex differencesMonths of recoveryAMI anginaInitial hospitalizationPerceived Stress ScalePatientsAnginaLess improvementLinear mixed-effects modelsFirst monthPsychological stressMixed-effects modelsWomenMonthsHigh levelsMenInfarctionStress ScalePerceived stress
2015
Balloon animals, guitars, and fewer blood draws: applying strategies from pediatrics to the treatment of hospitalized adults.
O'Brien MR, Rosenthal MS, Dharmarajan K, Krumholz HM. Balloon animals, guitars, and fewer blood draws: applying strategies from pediatrics to the treatment of hospitalized adults. Annals Of Internal Medicine 2015, 162: 726-7. PMID: 25984849, DOI: 10.7326/m14-2219.Peer-Reviewed Original ResearchMeSH KeywordsAdultChildChild, HospitalizedHospital UnitsHospitalizationHospitals, PediatricHumansOrganizational CultureStress, PsychologicalUnited StatesConceptsBlood drawSex Differences in Perceived Stress and Early Recovery in Young and Middle-Aged Patients With Acute Myocardial Infarction
Xu X, Bao H, Strait K, Spertus JA, Lichtman JH, D'Onofrio G, Spatz E, Bucholz EM, Geda M, Lorenze NP, Bueno H, Beltrame JF, Krumholz HM. Sex Differences in Perceived Stress and Early Recovery in Young and Middle-Aged Patients With Acute Myocardial Infarction. Circulation 2015, 131: 614-623. PMID: 25679303, PMCID: PMC4652932, DOI: 10.1161/circulationaha.114.012826.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMiddle-aged patientsMyocardial infarctionMental health statusWorse recoveryHealth statusSex differencesBaseline stressSex-based disparitiesYears of ageMultiple health outcomesQuality of lifeGreater mental stressSex-based differencesClinical characteristicsFemale sexEarly recoveryPerceived Stress ScaleGeneral populationGreater psychological stressHealth outcomesImprovement scoresInfarctionPatientsYounger age
2014
Addressing the Trauma of Hospitalization—Reply
Detsky AS, Krumholz HM. Addressing the Trauma of Hospitalization—Reply. JAMA 2014, 312: 1697-1697. PMID: 25335161, DOI: 10.1001/jama.2014.10179.Peer-Reviewed Original ResearchReducing the Trauma of Hospitalization
Detsky AS, Krumholz HM. Reducing the Trauma of Hospitalization. JAMA 2014, 311: 2169-2170. PMID: 24788549, DOI: 10.1001/jama.2014.3695.Peer-Reviewed Original Research
2012
Financial Stress and Outcomes after Acute Myocardial Infarction
Shah SJ, Krumholz HM, Reid KJ, Rathore SS, Mandawat A, Spertus JA, Ross JS. Financial Stress and Outcomes after Acute Myocardial Infarction. PLOS ONE 2012, 7: e47420. PMID: 23112814, PMCID: PMC3480393, DOI: 10.1371/journal.pone.0047420.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionSeattle Angina QuestionnaireLong-term outcomesMyocardial infarctionAMI patientsWorse long-term outcomesMulticenter US studyPost-AMI outcomesYear post-AMIDisease-specific QoLImportant risk factorHealth status outcomesWorse physical healthHealth care outcomesAngina QuestionnaireProspective registryInitial hospitalizationSecondary outcomesPrimary outcomeReadmission ratesPost-AMIRisk factorsCare characteristicsCare outcomesStatus outcomes
2006
The impact of late career job loss on myocardial infarction and stroke: a 10 year follow up using the health and retirement survey
Gallo WT, Teng HM, Falba TA, Kasl SV, Krumholz HM, Bradley EH. The impact of late career job loss on myocardial infarction and stroke: a 10 year follow up using the health and retirement survey. Occupational And Environmental Medicine 2006, 63: 683. PMID: 16798871, PMCID: PMC1839969, DOI: 10.1136/oem.2006.026823.Peer-Reviewed Original ResearchConceptsInvoluntary job lossJob lossRetirement SurveyLate-career job lossLate-career unemploymentLoss of employmentTrue costFinancial deprivationOlder workersPolicy makersUS HealthSubsequent myocardial infarctionMyocardial infarctionSubstantial health consequencesStudy frameCox proportional hazards analysisWorkersProportional hazards analysisPotential risk factorsUnemploymentYears of ageHealth changesJoblessnessRetirementEmployment
1998
Prognostic Importance of Emotional Support for Elderly Patients Hospitalized With Heart Failure
Krumholz H, Butler J, Miller J, Vaccarino V, Williams C, Mendes de Leon C, Seeman T, Kasl S, Berkman L. Prognostic Importance of Emotional Support for Elderly Patients Hospitalized With Heart Failure. Circulation 1998, 97: 958-964. PMID: 9529263, DOI: 10.1161/01.cir.97.10.958.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overEmotionsFemaleHeart FailureHumansMaleMultivariate AnalysisPrognosisSex FactorsStress, PsychologicalConceptsNonfatal cardiovascular eventsClinical heart failureHeart failureElderly patientsCardiovascular eventsPrognostic importanceNonfatal cardiovascular outcomesCoronary artery diseaseEmotional supportCommunity-based studyCardiovascular outcomesArtery diseaseIndependent predictorsUnadjusted analysesFunctional statusMedical recordsClinical severityOdds ratioEpidemiologic studiesHigh riskPatientsPsychosocial supportEstablished PopulationsAdmissionDemographic factors