2019
Evaluation of 30-Day Hospital Readmission and Mortality Rates Using Regression-Discontinuity Framework
Khera R, Wang Y, Nasir K, Lin Z, Krumholz HM. Evaluation of 30-Day Hospital Readmission and Mortality Rates Using Regression-Discontinuity Framework. Journal Of The American College Of Cardiology 2019, 74: 219-234. PMID: 31296295, PMCID: PMC8669780, DOI: 10.1016/j.jacc.2019.04.060.Peer-Reviewed Original ResearchMeSH KeywordsHeart FailureHumansMyocardial InfarctionPatient ReadmissionPneumoniaRegression AnalysisConceptsAcute myocardial infarctionHospital Readmissions Reduction ProgramHeart failureReadmission ratesElderly Medicare feeMedian readmission rateReadmissions Reduction ProgramPost-discharge daysInstitution of strategiesHospital readmissionReadmission riskMyocardial infarctionReadmission reductionCardiovascular conditionsEligible hospitalsMedicare feeReadmission penaltiesMortality rateDay 1Day 30ReadmissionDay 60HospitalU.S. hospitalsHospitalization
2018
Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study
Chekroud SR, Gueorguieva R, Zheutlin AB, Paulus M, Krumholz HM, Krystal JH, Chekroud AM. Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study. The Lancet Psychiatry 2018, 5: 739-746. PMID: 30099000, DOI: 10.1016/s2215-0366(18)30227-x.Peer-Reviewed Original ResearchConceptsMental health burdenCross-sectional studyHealth burdenExercise typeMental healthPhysical exerciseBehavioral Risk Factor Surveillance System surveyPast monthBody mass index categoriesEffective clinical targetsPrevention's Behavioral Risk Factor Surveillance System (BRFSS) surveysSelf-reported mental healthFrequency of exerciseSelf-reported physical healthFunction of exerciseMultiple sensitivity analysesPoor mental healthTerms of ageCause mortalityPrevious diagnosisPotential confoundersInterventional studyCardiovascular diseaseReduced riskIndex categories
2012
Hospitalist utilization and hospital performance on 6 publicly reported patient outcomes
Goodrich K, Krumholz HM, Conway PH, Lindenauer P, Auerbach AD. Hospitalist utilization and hospital performance on 6 publicly reported patient outcomes. Journal Of Hospital Medicine 2012, 7: 482-488. PMID: 22689448, PMCID: PMC3531241, DOI: 10.1002/jhm.1943.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPercentage of patientsHeart failurePatient outcomesOutcome measuresPresence of hospitalistsReadmission measuresCongestive heart failureCross-sectional studyMultivariable regression modelsComparison of hospitalQuality outcome measuresReadmission ratesIndependent predictorsMyocardial infarctionInpatient careHospitalist serviceHospitalist useMedical conditionsHospital personnelHospitalist programHospitalistsHospitalExpectation of improvementOutcomesHospital strategies for reducing risk-standardized mortality rates in acute myocardial infarction.
Bradley EH, Curry LA, Spatz ES, Herrin J, Cherlin EJ, Curtis JP, Thompson JW, Ting HH, Wang Y, Krumholz HM. Hospital strategies for reducing risk-standardized mortality rates in acute myocardial infarction. Annals Of Internal Medicine 2012, 156: 618-26. PMID: 22547471, PMCID: PMC3386642, DOI: 10.7326/0003-4819-156-9-201205010-00003.Peer-Reviewed Original ResearchConceptsRisk-standardized mortality ratesAcute myocardial infarctionLower risk-standardized mortality ratesMyocardial infarctionNurse championsMortality rateHospital strategiesHospital risk-standardized mortality ratesHospital-level factorsIntensive care unitAcute care hospitalsCardiac catheterization laboratoryCross-sectional surveyUnited Health FoundationCare hospitalCare unitCross-sectional designAMI casesAMI volumeCatheterization laboratoryHospital cliniciansHospitalMultivariate analysisPatientsHealth Foundation
2011
US Cardiologist Workforce From 1995 To 2007: Modest Growth, Lasting Geographic Maldistribution Especially In Rural Areas
Aneja S, Ross JS, Wang Y, Matsumoto M, Rodgers GP, Bernheim SM, Rathore SS, Krumholz HM. US Cardiologist Workforce From 1995 To 2007: Modest Growth, Lasting Geographic Maldistribution Especially In Rural Areas. Health Affairs 2011, 30: 2301-2309. PMID: 22147857, PMCID: PMC3332098, DOI: 10.1377/hlthaff.2011.0255.Peer-Reviewed Original ResearchConceptsPrimary care physiciansCare physiciansGeographic maldistributionChronic cardiovascular diseaseHospital referral regionsUse of telemedicineCardiology workforceNumber of cardiologistsTotal physician workforceCardiovascular diseaseCardiovascular careReferral regionsElderly populationUS populationTotal physiciansCardiologistsPhysiciansAge sixtyPhysician workforceDisadvantaged areasPercentRural areasPopulationDiseaseVariety of strategies
2010
Automated External Defibrillators and Survival After In-Hospital Cardiac Arrest
Chan PS, Krumholz HM, Spertus JA, Jones PG, Cram P, Berg RA, Peberdy MA, Nadkarni V, Mancini ME, Nallamothu BK, Investigators F. Automated External Defibrillators and Survival After In-Hospital Cardiac Arrest. JAMA 2010, 304: 2129-2136. PMID: 21078809, PMCID: PMC3587791, DOI: 10.1001/jama.2010.1576.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestCardiac arrestAED useHospital dischargeHospitalized patientsShockable rhythmNonshockable rhythmsIn-Hospital Cardiac ArrestMultivariable hierarchical regressionGeneral hospital wardsEntire study populationExternal defibrillatorsPropensity score analysisUse of AEDsCohort studyImproved survivalPatient factorsStudy populationMAIN OUTCOMEPatientsHospital wardsUS hospitalsHospital sitesHospital unitsAEDsMeta-analysis: effects of percutaneous coronary intervention versus medical therapy on angina relief.
Wijeysundera HC, Nallamothu BK, Krumholz HM, Tu JV, Ko DT. Meta-analysis: effects of percutaneous coronary intervention versus medical therapy on angina relief. Annals Of Internal Medicine 2010, 152: 370-9. PMID: 20231568, DOI: 10.7326/0003-4819-152-6-201003160-00007.Peer-Reviewed Original ResearchMeSH KeywordsAngina PectorisAngioplasty, Balloon, CoronaryCoronary DiseaseDrug-Eluting StentsHumansMyocardial InfarctionRegression AnalysisConceptsPercutaneous coronary interventionStable coronary artery diseaseEvidence-based medicationsCoronary artery diseaseMedical therapyAngina reliefCoronary interventionArtery diseaseIndependent reviewersTrials of PCIIncremental benefitRecent myocardial infarctionInclusion of patientsEvidence-based therapiesStudy-level dataDrug-eluting stentsRandom-effects modelMeta-regression analysisLong-term usePatient characteristicsCochrane LibraryContemporary trialsLanguage restrictionsMyocardial infarctionRecent trialsRecent Declines in Hospitalizations for Acute Myocardial Infarction for Medicare Fee-for-Service Beneficiaries
Chen J, Normand SL, Wang Y, Drye EE, Schreiner GC, Krumholz HM. Recent Declines in Hospitalizations for Acute Myocardial Infarction for Medicare Fee-for-Service Beneficiaries. Circulation 2010, 121: 1322-1328. PMID: 20212281, DOI: 10.1161/circulationaha.109.862094.Peer-Reviewed Original Research
2009
The Utility of Shorter Epochs in Direct Motion Monitoring
Dorsey K, Herrin J, Krumholz H, Irwin M. The Utility of Shorter Epochs in Direct Motion Monitoring. Research Quarterly For Exercise And Sport 2009, 80: 460-468. PMID: 19791632, PMCID: PMC3152374, DOI: 10.1080/02701367.2009.10599584.Peer-Reviewed Original ResearchElevated Admission Glucose and Mortality in Elderly Patients Hospitalized With Heart Failure
Kosiborod M, Inzucchi SE, Spertus JA, Wang Y, Masoudi FA, Havranek EP, Krumholz HM. Elevated Admission Glucose and Mortality in Elderly Patients Hospitalized With Heart Failure. Circulation 2009, 119: 1899-1907. PMID: 19332465, DOI: 10.1161/circulationaha.108.821843.Peer-Reviewed Original ResearchConceptsHeart failureAdmission glucoseElderly patientsDiabetes mellitusAdverse outcomesMultivariable Cox regression modelsAdmission glucose levelsElevated admission glucoseAcute myocardial infarctionCox regression modelCause mortalityMultivariable adjustmentEntire cohortGlucose controlMyocardial infarctionCardiovascular conditionsGlucose levelsLarge cohortElevated glucoseRepresentative cohortPatientsSignificant associationMortalityCohortMellitus
2008
Association of Early Follow-up After Acute Myocardial Infarction With Higher Rates of Medication Use
Daugherty SL, Ho PM, Spertus JA, Jones PG, Bach RG, Krumholz HM, Peterson ED, Rumsfeld JS, Masoudi FA. Association of Early Follow-up After Acute Myocardial Infarction With Higher Rates of Medication Use. JAMA Internal Medicine 2008, 168: 485-491. PMID: 18332293, DOI: 10.1001/archinte.168.5.485.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAngiotensin-Converting Enzyme InhibitorsAspirinContinuity of Patient CareEvidence-Based MedicineFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedMyocardial InfarctionPoisson DistributionProportional Hazards ModelsProspective StudiesRegistriesRegression AnalysisTreatment OutcomeConceptsAcute myocardial infarctionMedication useMyocardial infarctionMultivariable analysisEarly outpatientEvidence-based medication useProspective Registry Evaluating OutcomesSecondary analysisEarly Follow-upBeta-blocker useUse of aspirinCurrent guideline recommendationsPrimary care physiciansEvidence-based therapiesHigh rateEligible patientsStatin useClinical characteristicsHospital dischargePrimary outcomeCare physiciansGuideline recommendationsMedication prescriptionsFollow-upEvaluating OutcomesRegional Variation in Cardiac Catheterization Appropriateness and Baseline Risk After Acute Myocardial Infarction
Ko DT, Wang Y, Alter DA, Curtis JP, Rathore SS, Stukel TA, Masoudi FA, Ross JS, Foody JM, Krumholz HM. Regional Variation in Cardiac Catheterization Appropriateness and Baseline Risk After Acute Myocardial Infarction. Journal Of The American College Of Cardiology 2008, 51: 716-723. PMID: 18279735, DOI: 10.1016/j.jacc.2007.10.039.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCardiac catheterization useBaseline riskCardiac catheterizationMyocardial infarctionCardiology/American Heart Association classificationRisk-standardized mortality ratesAmerican Heart Association classificationCardiac catheterization ratesGRACE risk scoreHigh-risk patientsClass I patientsClass III patientsClass II patientsPatient appropriatenessCatheterization ratesHospital admissionI patientsPrimary outcomeAMI patientsII patientsIII patientsAppropriate indicationsInvasive strategyPhysician characteristics
2007
Cardiac Certificate of Need regulations and the availability and use of revascularization services
Ho V, Ross JS, Nallamothu BK, Krumholz HM. Cardiac Certificate of Need regulations and the availability and use of revascularization services. American Heart Journal 2007, 154: 767-775. PMID: 17893007, PMCID: PMC2084214, DOI: 10.1016/j.ahj.2007.06.031.Peer-Reviewed Original Research“America's Best Hospitals” in the Treatment of Acute Myocardial Infarction
Wang OJ, Wang Y, Lichtman JH, Bradley EH, Normand SL, Krumholz HM. “America's Best Hospitals” in the Treatment of Acute Myocardial Infarction. JAMA Internal Medicine 2007, 167: 1345-1351. PMID: 17620526, DOI: 10.1001/archinte.167.13.1345.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionStandardized mortality ratioBest HospitalsMyocardial infarctionAmerica's Best HospitalsTreatment of AMIMedicare administrative dataHeart surgeryMortality ratioLower riskMortality rateHospitalQuartile distributionPatientsRSMRInfarctionAdministrative dataOne-thirdHierarchical regression modelsRSMRsRegression modelsTreatmentSurgeryAdmissionQuartile
2006
An Administrative Claims Model Suitable for Profiling Hospital Performance Based on 30-Day Mortality Rates Among Patients With Heart Failure
Krumholz HM, Wang Y, Mattera JA, Wang Y, Han LF, Ingber MJ, Roman S, Normand SL. An Administrative Claims Model Suitable for Profiling Hospital Performance Based on 30-Day Mortality Rates Among Patients With Heart Failure. Circulation 2006, 113: 1693-1701. PMID: 16549636, DOI: 10.1161/circulationaha.105.611194.Peer-Reviewed Original ResearchAn Administrative Claims Model Suitable for Profiling Hospital Performance Based on 30-Day Mortality Rates Among Patients With an Acute Myocardial Infarction
Krumholz HM, Wang Y, Mattera JA, Wang Y, Han LF, Ingber MJ, Roman S, Normand SL. An Administrative Claims Model Suitable for Profiling Hospital Performance Based on 30-Day Mortality Rates Among Patients With an Acute Myocardial Infarction. Circulation 2006, 113: 1683-1692. PMID: 16549637, DOI: 10.1161/circulationaha.105.611186.Peer-Reviewed Original Research
2004
Predictors of cardiologist care for older patients hospitalized for heart failure
Foody JM, Rathore SS, Wang Y, Herrin J, Masoudi FA, Havranek EP, Radford MJ, Krumholz HM. Predictors of cardiologist care for older patients hospitalized for heart failure. American Heart Journal 2004, 147: 66-73. PMID: 14691421, DOI: 10.1016/j.ahj.2003.07.005.Peer-Reviewed Original ResearchConceptsHeart failureSpecialty careOlder patientsMultivariable hierarchical logistic regression modelsCoronary Artery Bypass GraftingChronic obstructive pulmonary diseasePercutaneous transluminal coronary angioplastyArtery Bypass GraftingHeart failure careObstructive pulmonary diseaseTransluminal coronary angioplastyHierarchical logistic regression modelsLogistic regression modelsCardiologist careBypass GraftingHospital factorsPatient characteristicsCardiology consultCoronary angioplastyCoronary diseasePulmonary diseaseClinical presentationCardiology carePatient raceMedicare patients
1999
Variations in and correlates of length of stay in academic hospitals among patients with heart failure resulting from systolic dysfunction.
Krumholz HM, Chen YT, Bradford WD, Cerese J. Variations in and correlates of length of stay in academic hospitals among patients with heart failure resulting from systolic dysfunction. The American Journal Of Managed Care 1999, 5: 715-23. PMID: 10538451.Peer-Reviewed Original ResearchConceptsLength of stayCongestive heart failureHeart failureSystolic dysfunctionPatient characteristicsAcademic hospitalCollaborative quality improvement projectIndividual hospitalsAdmission clinical characteristicsRetrospective cohort studyPrincipal discharge diagnosisNumber of patientsQuality improvement projectUniversity HealthSystem ConsortiumCorrelates of lengthHospital stayPeripheral edemaClinical characteristicsCohort studyRenal failureClinical factorsMajor complicationsHospital eventsRegression modelsAtrial fibrillation
1993
Sex differences in cardiac adaptation to isolated systolic hypertension
Krumholz H, Larson M, Levy D. Sex differences in cardiac adaptation to isolated systolic hypertension. The American Journal Of Cardiology 1993, 72: 310-313. PMID: 8342510, DOI: 10.1016/0002-9149(93)90678-6.Peer-Reviewed Original ResearchConceptsSystolic hypertensionLV massBlood pressureLV hypertrophyApparent cardiovascular diseaseDiastolic blood pressureBody mass indexLeft ventricular massLV wall thicknessM-mode echocardiographyM-mode echocardiogramsFramingham Offspring StudyBlood glucose levelsFramingham Heart StudyAntihypertensive medicationsDiastolic hypertensionNormotensive subjectsConcentric hypertrophyLV dilationMass indexIndex examinationChamber enlargementVentricular massCardiac adaptationCardiovascular disease