2022
Temporal trends in postoperative and ventilator-associated pneumonia in the United States
Metersky M, Wang Y, Klompas M, Eckenrode S, Mathew J, Krumholz H. Temporal trends in postoperative and ventilator-associated pneumonia in the United States. Infection Control And Hospital Epidemiology 2022, 44: 1247-1254. PMID: 36326283, DOI: 10.1017/ice.2022.264.Peer-Reviewed Original ResearchConceptsVentilator-associated pneumoniaMajor surgical proceduresPostoperative pneumoniaAcute myocardial infarctionSurgical proceduresHeart failureMyocardial infarctionMedicare Patient Safety Monitoring SystemAnnual riskRetrospective cohort studyPrior yearRisk-adjusted ratesAdverse event measuresCohort studyRetrospective reviewPneumoniaPatientsInfarctionUnited StatesRiskSignificant changesYearsTemporal trendsFailureLeading Causes of Death Among Adults Aged 25 to 44 Years by Race and Ethnicity in Texas During the COVID-19 Pandemic, March to December 2020
Faust JS, Chen AJ, Tiako M, Du C, Li SX, Krumholz HM, Barnett ML. Leading Causes of Death Among Adults Aged 25 to 44 Years by Race and Ethnicity in Texas During the COVID-19 Pandemic, March to December 2020. JAMA Internal Medicine 2022, 182: 87-90. PMID: 34807250, PMCID: PMC8609460, DOI: 10.1001/jamainternmed.2021.6734.Peer-Reviewed Original Research
2021
All-Cause Excess Mortality and COVID-19–Related Mortality Among US Adults Aged 25-44 Years, March-July 2020
Faust JS, Krumholz HM, Du C, Mayes KD, Lin Z, Gilman C, Walensky RP. All-Cause Excess Mortality and COVID-19–Related Mortality Among US Adults Aged 25-44 Years, March-July 2020. JAMA 2021, 325: 785-787. PMID: 33325994, PMCID: PMC7745134, DOI: 10.1001/jama.2020.24243.Peer-Reviewed Original Research
2015
Trends in Short- and Long-Term Outcomes for Takotsubo Cardiomyopathy Among Medicare Fee-for-Service Beneficiaries, 2007 to 2012
Murugiah K, Wang Y, Desai NR, Spatz ES, Nuti SV, Dreyer RP, Krumholz HM. Trends in Short- and Long-Term Outcomes for Takotsubo Cardiomyopathy Among Medicare Fee-for-Service Beneficiaries, 2007 to 2012. JACC Heart Failure 2015, 4: 197-205. PMID: 26746377, PMCID: PMC5323042, DOI: 10.1016/j.jchf.2015.09.013.Peer-Reviewed Original ResearchConceptsLong-term outcomesReadmission ratesNonwhite patientsHospitalization ratesSecondary diagnosisMedicare feeYears of ageTakotsubo cardiomyopathyWorse outcomesWhite racePatientsService beneficiariesHospitalMortalityTime pointsOutcomesHospitalizationCohortDiagnosisRepresentative dataTakotsuboTTCReadmissionCardiomyopathyYears
2014
Readmission Rates and Long-Term Hospital Costs Among Survivors of an In-Hospital Cardiac Arrest
Chan PS, Nallamothu BK, Krumholz HM, Curtis LH, Li Y, Hammill BG, Spertus JA. Readmission Rates and Long-Term Hospital Costs Among Survivors of an In-Hospital Cardiac Arrest. Circulation Cardiovascular Quality And Outcomes 2014, 7: 889-895. PMID: 25351479, PMCID: PMC4241155, DOI: 10.1161/circoutcomes.114.000925.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestCardiac arrestInpatient costsMean inpatient costsLarge national registryInpatient resource useNeurological statusReadmission patternsHospital dispositionPatient demographicsReadmission ratesMean ageInpatient useNational registryYounger ageReadmissionArrestAgeYearsDaysPatientsRegistryResource useSurvivors
2011
Improvements in Door-to-Balloon Time in the United States, 2005 to 2010
Krumholz HM, Herrin J, Miller LE, Drye EE, Ling SM, Han LF, Rapp MT, Bradley EH, Nallamothu BK, Nsa W, Bratzler DW, Curtis JP. Improvements in Door-to-Balloon Time in the United States, 2005 to 2010. Circulation 2011, 124: 1038-1045. PMID: 21859971, PMCID: PMC3598634, DOI: 10.1161/circulationaha.111.044107.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPercutaneous coronary interventionBalloon timeCoronary interventionMedian timeST-segment elevation myocardial infarctionHigher median timeCharacteristics of patientsPercentage of patientsTimeliness of treatmentYears of ageRegistry studyMyocardial infarctionInpatient measuresPatientsHospital groupMedicaid ServicesCalendar yearInterventionMinutesMedianGroupYearsPercentageInfarctionUse of Medical Imaging Procedures With Ionizing Radiation in Children: A Population-Based Study
Dorfman AL, Fazel R, Einstein AJ, Applegate KE, Krumholz HM, Wang Y, Christodoulou E, Chen J, Sanchez R, Nallamothu BK. Use of Medical Imaging Procedures With Ionizing Radiation in Children: A Population-Based Study. JAMA Pediatrics 2011, 165: 458-464. PMID: 21199972, PMCID: PMC3686496, DOI: 10.1001/archpediatrics.2010.270.Peer-Reviewed Original ResearchConceptsDiagnostic imaging proceduresTomographic scanImaging proceduresRetrospective cohort analysisPopulation-based ratesPediatric populationPlain radiographyCohort analysisHigh dosesMedical diagnostic imaging proceduresStudy periodAppropriate useChildrenHigh rateMedical imaging proceduresScansFrequent useHealth care marketUS health care marketYearsPatientsInfantsPopulationCare marketUnitedHealthcare
2009
Pooled Analysis of Rofecoxib Placebo-Controlled Clinical Trial Data: Lessons for Postmarket Pharmaceutical Safety Surveillance
Ross JS, Madigan D, Hill KP, Egilman DS, Wang Y, Krumholz HM. Pooled Analysis of Rofecoxib Placebo-Controlled Clinical Trial Data: Lessons for Postmarket Pharmaceutical Safety Surveillance. JAMA Internal Medicine 2009, 169: 1976-1985. PMID: 19933959, PMCID: PMC2830805, DOI: 10.1001/archinternmed.2009.394.Peer-Reviewed Original ResearchMeSH KeywordsAdverse Drug Reaction Reporting SystemsCardiovascular SystemCyclooxygenase 2 InhibitorsDrug IndustryHumansIncidenceLactonesMyocardial InfarctionRandomized Controlled Trials as TopicRisk AssessmentSafety-Based Drug WithdrawalsSulfonesTime FactorsUnited StatesUnited States Food and Drug AdministrationConceptsPlacebo-controlled trialVoluntary market withdrawalAdverse eventsCardiovascular riskThromboembolic adverse eventsMain outcome measurementsClinical trial dataRofecoxib groupOutcome measurementsTrial dataPlaceboTrial durationSafety surveillanceTrialsMarket withdrawalDeathRiskP-valueSurveillance effortsSubjectsWithdrawalRofecoxibYearsIncidenceDoseExposure to Low-Dose Ionizing Radiation from Medical Imaging Procedures
Fazel R, Krumholz HM, Wang Y, Ross JS, Chen J, Ting HH, Shah ND, Nasir K, Einstein AJ, Nallamothu BK. Exposure to Low-Dose Ionizing Radiation from Medical Imaging Procedures. New England Journal Of Medicine 2009, 361: 849-857. PMID: 19710483, PMCID: PMC3707303, DOI: 10.1056/nejmoa0901249.Peer-Reviewed Original ResearchConceptsCumulative effective dosesCumulative effective doseEffective dosesEffective doseMean cumulative effective doseImaging proceduresLow-dose ionizing radiationPopulation-based ratesMedian effective doseOutpatient settingGeneral populationHigh dosesUtilization dataDosesEnrolleesStudy periodRadiation exposureNuclear imagingDoseAnnual effective dosesMedical imaging proceduresUnited StatesExposureHealth care marketYears
2008
Factors Associated With Longer Time From Symptom Onset to Hospital Presentation for Patients With ST-Elevation Myocardial Infarction
Ting HH, Bradley EH, Wang Y, Lichtman JH, Nallamothu BK, Sullivan MD, Gersh BJ, Roger VL, Curtis JP, Krumholz HM. Factors Associated With Longer Time From Symptom Onset to Hospital Presentation for Patients With ST-Elevation Myocardial Infarction. JAMA Internal Medicine 2008, 168: 959-968. PMID: 18474760, PMCID: PMC4858313, DOI: 10.1001/archinte.168.9.959.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionMyocardial infarctionHospital presentationSymptom onsetPatient subgroupsRisk factorsOnset of symptomsQuality of careRace/ethnicityNational registryPatient responsivenessInfarctionPatientsReference groupSubgroupsWomenMenCareOnsetMinutesPresentationYearsHoursGeometric meanDiabetics
2006
National Trends in Outcomes Among Elderly Patients with Heart Failure
Kosiborod M, Lichtman JH, Heidenreich PA, Normand SL, Wang Y, Brass LM, Krumholz HM. National Trends in Outcomes Among Elderly Patients with Heart Failure. The American Journal Of Medicine 2006, 119: 616.e1-616.e7. PMID: 16828634, DOI: 10.1016/j.amjmed.2005.11.019.Peer-Reviewed Original ResearchConceptsHeart failure managementHeart failureElderly patientsHospital readmissionFailure managementOne-year mortalityThirty-day readmissionRisk-adjusted analysisCause hospital readmissionReferent yearCause mortalityReadmissionMedicare beneficiariesBetter outcomesMortality trendsMortalityPatientsRisk adjustmentTemporal trendsNational trendsOutcomesNational sampleFailureYears
2005
Validity of Using an Electronic Medical Record for Assessing Quality of Care in an Outpatient Setting
Benin AL, Vitkauskas G, Thornquist E, Shapiro ED, Concato J, Aslan M, Krumholz HM. Validity of Using an Electronic Medical Record for Assessing Quality of Care in an Outpatient Setting. Medical Care 2005, 43: 691-698. PMID: 15970784, DOI: 10.1097/01.mlr.0000167185.26058.8e.Peer-Reviewed Original ResearchConceptsElectronic medical recordsManagement of pharyngitisMedical recordsHealth Plan Employer DataDiagnostic testsEpisode of pharyngitisOutpatient electronic medical recordsProportion of episodesDiagnosis of pharyngitisOutpatient settingTotal episodesPharyngitisEmployer DataElectronic databasesDiagnostic testingClinical encountersMeasures of qualityEpisodesComplete evaluationCareAssessing QualityPediatricsYearsProportionDiagnosis
2002
The Burden of Chronic Congestive Heart Failure in Older Persons: Magnitude and Implications for Policy and Research
Masoudi FA, Havranek EP, Krumholz HM. The Burden of Chronic Congestive Heart Failure in Older Persons: Magnitude and Implications for Policy and Research. Heart Failure Reviews 2002, 7: 9-16. PMID: 11790919, DOI: 10.1023/a:1013793621248.Peer-Reviewed Original ResearchConceptsHeart failureOlder populationChronic congestive heart failureOlder personsPoor long-term survivalMore hospital admissionsCongestive heart failureLong-term survivalHospital admissionHigh riskFailureSingle conditionPopulationPersonsHospitalizationAdmissionDearth of researchYearsDiagnosisMonths
1998
Clinical correlates of in-hospital costs for acute myocardial infarction in patients 65 years of age and older
Krumholz H, Chen J, Murillo J, Cohen D, Radford M. Clinical correlates of in-hospital costs for acute myocardial infarction in patients 65 years of age and older. American Heart Journal 1998, 135: 523-531. PMID: 9506340, DOI: 10.1016/s0002-8703(98)70331-x.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPatients 65 yearsHospital costsMyocardial infarctionAcute myocardial infarction hospitalizationsActual clinical practiceMyocardial infarction hospitalizationsClinical characteristicsAdverse outcomesClinical correlatesMedical recordsClinical practiceHospital proceduresRoom costsInfarctionStudy sampleTotal meanRelative paucityAgeLarge proportionCorrelatesHospitalizationPatientsHospitalYears
1997
Differences in physician compensation for cardiovascular services by age, sex, and race.
Krumholz HM, Fendrick AM, Williams C, Hynes WM. Differences in physician compensation for cardiovascular services by age, sex, and race. The American Journal Of Managed Care 1997, 3: 557-63. PMID: 10169524.Peer-Reviewed Original ResearchConceptsConsecutive patientsCoronary angioplastyCardiovascular servicesPercutaneous transluminal coronary angioplastyPatients 75 yearsTransluminal coronary angioplastyPercutaneous coronary angioplastyPatients 40Patients 65Patient characteristicsPatient groupInsurance statusCardiology practicePhysiciansStress testingAngioplastySignificant differencesPatientsLower ratesSimilar differencesPhysician compensationAgeSexYearsDifferences
1995
Readmission rates, 30 days and 365 days postdischarge, among the 20 most frequent DRG groups, Medicare inpatients age 65 or older in Connecticut hospitals, fiscal years 1991, 1992, and 1993.
Hennen J, Krumholz HM, Radford MJ, Meehan TP. Readmission rates, 30 days and 365 days postdischarge, among the 20 most frequent DRG groups, Medicare inpatients age 65 or older in Connecticut hospitals, fiscal years 1991, 1992, and 1993. Connecticut Medicine 1995, 59: 263-70. PMID: 7600797.Peer-Reviewed Original ResearchConceptsCrude readmission ratesReadmission ratesDRG categoriesConnecticut acute care hospitalsAge 65Three-year study periodStudy periodElderly Medicare beneficiariesAcute care hospitalsInpatients age 65Days postdischargeFiscal year 1991Inpatient admissionsInpatients ageConnecticut hospitalsAge 75Medicare beneficiariesAge groupsDRG groupsSignificant decreaseHospitalCorresponding ratesAgeFY 1993YearsTwenty most frequent DRG groups among Medicare inpatients age 65 or older in Connecticut hospitals, fiscal years 1991, 1992, and 1993.
Hennen J, Krumholz HM, Radford MJ. Twenty most frequent DRG groups among Medicare inpatients age 65 or older in Connecticut hospitals, fiscal years 1991, 1992, and 1993. Connecticut Medicine 1995, 59: 11-5. PMID: 7859443.Peer-Reviewed Original ResearchConceptsDRG categoriesConnecticut acute care hospitalsElderly Medicare beneficiariesElderly Medicare patientsAge group 65Acute care hospitalsInpatients age 65Care hospitalFiscal year 1991Inpatient admissionsInpatients ageConnecticut hospitalsGroup 65Medicare patientsAge subgroupsMedicare beneficiariesThree-year study periodAge 65Study periodDRG groupsNumber of dischargesMedicare dischargesHospitalYear periodYears
1993
Cost-effectiveness of a smoking cessation program after myocardial infarction
Krumholz H, Cohen B, Tsevat J, Pasternak R, Weinstein M. Cost-effectiveness of a smoking cessation program after myocardial infarction. Journal Of The American College Of Cardiology 1993, 22: 1697-1702. PMID: 8227841, DOI: 10.1016/0735-1097(93)90598-u.Peer-Reviewed Original ResearchConceptsSmoking cessation programAcute myocardial infarctionNurse-managed smoking cessation programCessation programsMyocardial infarctionYears of lifeBeta-adrenergic antagonist therapyLife expectancyOne-way sensitivity analysesTwo-way sensitivity analysesCost-effective interventionHealth care resourcesAntagonist therapySmoking ratesInfarctionCare resourcesSmokersInterventionProgram costsYearsExpectancyTherapyLife