2024
A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression
Oikonomou E, Holste G, Yuan N, Coppi A, McNamara R, Haynes N, Vora A, Velazquez E, Li F, Menon V, Kapadia S, Gill T, Nadkarni G, Krumholz H, Wang Z, Ouyang D, Khera R. A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression. JAMA Cardiology 2024, 9: 534-544. PMID: 38581644, PMCID: PMC10999005, DOI: 10.1001/jamacardio.2024.0595.Peer-Reviewed Original ResearchCardiac magnetic resonanceAortic valve replacementCardiac magnetic resonance imagingAV VmaxSevere ASAortic stenosisCohort studyPeak aortic valve velocityCohort study of patientsAortic valve velocityCohort of patientsTraditional cardiovascular risk factorsAssociated with faster progressionStudy of patientsCedars-Sinai Medical CenterAssociated with AS developmentCardiovascular risk factorsCardiovascular imaging modalitiesIndependent of ageModerate ASEjection fractionEchocardiographic studiesValve replacementRisk stratificationCardiac structure
2022
Sex-Specific Risk Factors Associated With First Acute Myocardial Infarction in Young Adults
Lu Y, Li SX, Liu Y, Rodriguez F, Watson KE, Dreyer RP, Khera R, Murugiah K, D’Onofrio G, Spatz ES, Nasir K, Masoudi FA, Krumholz HM. Sex-Specific Risk Factors Associated With First Acute Myocardial Infarction in Young Adults. JAMA Network Open 2022, 5: e229953. PMID: 35503221, PMCID: PMC9066284, DOI: 10.1001/jamanetworkopen.2022.9953.Peer-Reviewed Original ResearchConceptsFirst acute myocardial infarctionAcute myocardial infarctionPsychosocial risk factorsRisk factor profilePopulation attributable fractionRisk factor associationsRisk factorsOdds ratioYoung womenAMI subtypesMyocardial infarctionPrevention of AMIType 1 acute myocardial infarctionFactor profileRisk of AMITraditional cardiovascular risk factorsSex-specific risk factorsFactor associationsYoung adultsRisk factor modificationCardiovascular risk factorsStrong associationNutrition Examination SurveyCase-control studyPopulation-based controls
1999
Risk factors for heart failure in the elderly: a prospective community-based study
Chen Y, Vaccarino V, Williams C, Butler J, Berkman L, Krumholz H. Risk factors for heart failure in the elderly: a prospective community-based study. The American Journal Of Medicine 1999, 106: 605-612. PMID: 10378616, DOI: 10.1016/s0002-9343(99)00126-6.Peer-Reviewed Original ResearchConceptsTraditional cardiovascular risk factorsCardiovascular risk factorsHeart failureRisk factorsMyocardial infarctionRisk ratioCommunity-based elderly populationProportional hazards regression modelsProspective community-based studyIncident heart failureBody mass indexHazards regression modelsConfidence intervalsCommunity-based studyManagement of diabetesYears of ageConnecticut cohortChart reviewBlood pressureIndependent predictorsMass indexMale sexElderly ProgramPulse pressurePreventive strategies
1995
Prognosis of left ventricular geometric patterns in the Framingham heart study
Krumholz H, Larson M, Levy D. Prognosis of left ventricular geometric patterns in the Framingham heart study. Journal Of The American College Of Cardiology 1995, 25: 879-884. PMID: 7884091, DOI: 10.1016/0735-1097(94)00473-4.Peer-Reviewed Original ResearchConceptsCardiovascular risk factorsLeft ventricular massTraditional cardiovascular risk factorsLeft ventricular geometric patternsVentricular geometric patternsVentricular massConcentric hypertrophyLeft ventricular geometryRisk factorsPopulation-based sampleCardiovascular diseaseFramingham Heart StudyVentricular geometryConcentric remodelingEccentric hypertrophyHeart StudyNormal geometryCardiovascular disease risk factorsProportional hazards regression modelsLittle prognostic informationIncremental prognostic valueApparent cardiovascular diseaseIncident cardiovascular diseaseDisease risk factorsHazards regression models