2016
Life Expectancy after Myocardial Infarction, According to Hospital Performance
Bucholz EM, Butala NM, Ma S, Normand ST, Krumholz HM. Life Expectancy after Myocardial Infarction, According to Hospital Performance. New England Journal Of Medicine 2016, 375: 1332-1342. PMID: 27705249, PMCID: PMC5118048, DOI: 10.1056/nejmoa1513223.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionRisk-standardized mortality ratesMyocardial infarctionLife expectancyMortality rateHospital performanceCooperative Cardiovascular ProjectProportional hazards modelLong-term survivalCase-mix severityLonger life expectancySurvival benefitInfarctionMedicare beneficiariesPatientsHospital case mixCase mixHospitalSurvival curvesQuintileStudy sampleSignificant differencesEarly survivalExpectancySurvivalLife Years Gained From Smoking-Cessation Counseling After Myocardial Infarction
Bucholz EM, Beckman AL, Kiefe CI, Krumholz HM. Life Years Gained From Smoking-Cessation Counseling After Myocardial Infarction. American Journal Of Preventive Medicine 2016, 52: 38-46. PMID: 27692757, PMCID: PMC5459385, DOI: 10.1016/j.amepre.2016.08.013.Peer-Reviewed Original ResearchConceptsSmoking cessation counselingAcute myocardial infarctionLong-term survival benefitLife yearsSurvival benefitMyocardial infarctionLife expectancyLower short-term mortalityHigher crude mortalityLong-term mortalityProspective cohort studyShort-term mortalityCooperative Cardiovascular ProjectProportional hazards modelLonger life expectancyCohort studyElderly patientsElderly smokersOlder smokersCrude mortalitySurvival differencesHospital characteristicsSmokersHazards modelLower mortality
2015
Excess weight and life expectancy after acute myocardial infarction: The obesity paradox reexamined
Bucholz EM, Beckman AL, Krumholz HA, Krumholz HM, conducted. B. Excess weight and life expectancy after acute myocardial infarction: The obesity paradox reexamined. American Heart Journal 2015, 172: 173-181. PMID: 26856230, PMCID: PMC5097250, DOI: 10.1016/j.ahj.2015.10.024.Peer-Reviewed Original ResearchConceptsNormal weight patientsAcute myocardial infarctionBody mass indexHigher body mass indexLong-term survivalObese patientsOverweight patientsObesity paradoxExcess weightMyocardial infarctionLife expectancyTime of AMIHigher crude mortalityTime pointsShort-term mortalityCooperative Cardiovascular ProjectMedical record studyProportional hazards modelYears of ageMorbid obesityOlder patientsSurvival benefitYounger patientsCrude mortalityBMI groups
2004
Association Between Functional Status and Use and Effectiveness of Beta‐Blocker Prophylaxis in Elderly Survivors of Acute Myocardial Infarction
Vitagliano G, Curtis JP, Concato J, Feinstein AR, Radford MJ, Krumholz HM. Association Between Functional Status and Use and Effectiveness of Beta‐Blocker Prophylaxis in Elderly Survivors of Acute Myocardial Infarction. Journal Of The American Geriatrics Society 2004, 52: 495-501. PMID: 15066062, DOI: 10.1111/j.1532-5415.2004.52153.x.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAcute DiseaseAdrenergic beta-AntagonistsAge FactorsAgedAged, 80 and overCross-Sectional StudiesDrug PrescriptionsDrug UtilizationFemaleGeriatric AssessmentHumansLogistic ModelsMaleMultivariate AnalysisMyocardial InfarctionPatient DischargePatient SelectionPractice Patterns, Physicians'Proportional Hazards ModelsRetrospective StudiesSurvival AnalysisTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionHospital dischargeFunctional impairmentElderly patientsMyocardial infarctionAcute myocardial infarction survivorsBeta-blocker prescriptionBeta-blocker prophylaxisBeta-blocker treatmentRetrospective cohort studySimilar survival benefitMain outcome measuresMyocardial infarction survivorsAcute care hospitalsEligible patientsCohort studySurvival benefitCare hospitalFunctional statusNational cohortInfarction survivorsOutcome measuresElderly survivorsPatientsCognitive impairment
2002
Nonsteroidal antiinflammatory drugs after acute myocardial infarction
Ko D, Wang Y, Berger AK, Radford MJ, Krumholz HM. Nonsteroidal antiinflammatory drugs after acute myocardial infarction. American Heart Journal 2002, 143: 475-481. PMID: 11868054, DOI: 10.1067/mhj.2002.121270.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNonsteroidal antiinflammatory drugsNSAID therapyMyocardial infarctionAddition of aspirinMortality rateAspirin therapyElderly patientsAntiinflammatory drugsMedicare beneficiariesUse of NSAIDsRetrospective medical record reviewAdditional survival benefitMedical record reviewCooperative Cardiovascular ProjectElderly Medicare beneficiariesHospital dischargeOlder patientsSurvival benefitRecord reviewClinical informationInfarctionAspirinPatientsMedications
2001
Effectiveness of beta-blocker therapy after acute myocardial infarction in elderly patients with chronic obstructive pulmonary disease or asthma
Chen J, Radford M, Wang Y, Marciniak T, Krumholz H. Effectiveness of beta-blocker therapy after acute myocardial infarction in elderly patients with chronic obstructive pulmonary disease or asthma. Journal Of The American College Of Cardiology 2001, 37: 1950-1956. PMID: 11401137, DOI: 10.1016/s0735-1097(01)01225-6.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseBeta-blocker therapyAcute myocardial infarctionOne-year mortalityObstructive pulmonary diseasePulmonary diseaseElderly patientsSurvival benefitMyocardial infarctionSevere chronic obstructive pulmonary diseaseBeta-agonist therapyElderly AMI patientsSevere pulmonary diseaseCooperative Cardiovascular ProjectAsthma patientsClinical factorsAMI patientsMild diseaseClinical trialsDischarge useSevere diseaseAsthmaPatientsTherapyDisease
2000
Thrombolytic therapy in older patients
Berger A, Radford M, Wang Y, Krumholz H. Thrombolytic therapy in older patients. Journal Of The American College Of Cardiology 2000, 36: 366-374. PMID: 10933344, DOI: 10.1016/s0735-1097(00)00723-3.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrimary angioplastyThrombolytic therapyOlder patientsBundle branch blockAcute reperfusionBranch blockST-segment elevationPatients age 65Population-based cohortReperfusion strategyReperfusion therapyHospital arrivalSurvival benefitSymptom onsetSegment elevationPhysician factorsST elevationMyocardial infarctionNational cohortAngioplastyBetter survivalMedicare beneficiariesLower mortalityPatientsCare and outcomes of elderly patients with acute myocardial infarction by physician specialty: the effects of comorbidity and functional limitations
Chen J, Radford M, Wang Y, Krumholz H. Care and outcomes of elderly patients with acute myocardial infarction by physician specialty: the effects of comorbidity and functional limitations. The American Journal Of Medicine 2000, 108: 460-469. PMID: 10781778, DOI: 10.1016/s0002-9343(00)00331-4.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedCardiologyComorbidityFamily PracticeFemaleGeriatric AssessmentHospital MortalityHospitalizationHumansInternal MedicineMaleMedicareMyocardial InfarctionPractice Guidelines as TopicPractice Patterns, Physicians'Quality Indicators, Health CareRetrospective StudiesSeverity of Illness IndexSurvival AnalysisTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionMyocardial infarctionGeneral practitionersPhysician specialtyFunctional limitationsComorbid illnessesPatient characteristicsSurvival benefitComorbid conditionsCardiology careNational Cooperative Cardiovascular ProjectEffect of comorbidityCooperative Cardiovascular ProjectBoard-certified cardiologistsInternal medicine subspecialistsMost comorbiditiesClinical characteristicsElderly patientsClinical presentationSpecialty careHospital characteristicsExcess mortalityBaseline differencesMedicine subspecialistsGeneral internists
1995
A cost-effectiveness model of thrombolytic therapy for acute myocardial infarction
Kalish S, Gurwitz J, Krumholz H, Avorn J. A cost-effectiveness model of thrombolytic therapy for acute myocardial infarction. Journal Of General Internal Medicine 1995, 10: 321-330. PMID: 7562123, DOI: 10.1007/bf02599951.Peer-Reviewed Original ResearchConceptsQuality-adjusted life yearsTissue plasminogen activatorAcute myocardial infarctionAdditional quality-adjusted life yearMyocardial infarctionGUSTO trialThrombolytic therapyOne-year mortality dataOccluded Coronary Arteries (GUSTO-I) trialMortality dataPlasminogen activatorLong-term medical costsCoronary Arteries trialOne-year mortalityUse of streptokinaseInferior wall infarctionCost-effective therapyCost-effectiveness modelDecision analysis modelSurvival benefitSymptom onsetClinical outcomesRelative survival advantageThrombolytic agentsSurvival advantage