2021
The association of neighborhood walkability with health outcomes in older adults after acute myocardial infarction: The SILVER-AMI study
Roy B, Hajduk AM, Tsang S, Geda M, Riley C, Krumholz HM, Chaudhry SI. The association of neighborhood walkability with health outcomes in older adults after acute myocardial infarction: The SILVER-AMI study. Preventive Medicine Reports 2021, 23: 101391. PMID: 34040930, PMCID: PMC8141908, DOI: 10.1016/j.pmedr.2021.101391.Peer-Reviewed Original ResearchAcute myocardial infarctionSILVER-AMI StudyPhysical activityMental healthMyocardial infarctionNeighborhood walkabilityOlder adultsHealth outcomesSocial supportCommunity-Living AdultsSecondary outcomesCoronary diseasePrimary outcomeSF-12Longitudinal cohortPhysical therapyAdjusted modelSurvival timeBetter outcomesGreater walkabilitySurvival analysisMobility limitationsPhysical healthOutcomesAdults
2011
Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome
Morgan TM, House JA, Cresci S, Jones P, Allayee H, Hazen SL, Patel Y, Patel RS, Eapen DJ, Waddy SP, Quyyumi AA, Kleber ME, März W, Winkelmann BR, Boehm BO, Krumholz HM, Spertus JA. Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome. BMC Medical Genomics 2011, 12: 127. PMID: 21957892, PMCID: PMC3190329, DOI: 10.1186/1471-2350-12-127.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overAminohydrolasesCohort StudiesFemaleFormate-Tetrahydrofolate LigaseGenetic VariationGenome-Wide Association StudyGenotypeHumansKaplan-Meier EstimateMaleMethylenetetrahydrofolate Dehydrogenase (NADP)Middle AgedMultienzyme ComplexesMyocardial InfarctionPolymorphism, Single NucleotideProportional Hazards ModelsRisk FactorsWhite PeopleConceptsAcute coronary syndromeCoronary syndromeCoronary artery disease patientsKaplan-Meier survival analysisACS risk factorsCoronary artery diseaseUniversity-affiliated hospitalMyocardial infarction patientsPremature myocardial infarctionRace-adjusted analysesACS mortalityArtery diseaseCox regressionBorderline significanceDisease patientsInfarction patientsMyocardial infarctionRisk factorsMortality hazardIndependent cohortSurvival analysisDiverse cohortPatientsRelevant covariatesBackgroundGenome-wide association studies
2009
Predictors of Venous Thromboembolism in Patients with Advanced Common Solid Cancers
Hall IE, Andersen MS, Krumholz HM, Gross CP. Predictors of Venous Thromboembolism in Patients with Advanced Common Solid Cancers. Journal Of Cancer Epidemiology 2009, 2009: 182521. PMID: 20445797, PMCID: PMC2859683, DOI: 10.1155/2009/182521.Peer-Reviewed Original ResearchVenous thromboembolismVTE riskOlder patientsAdvanced cancerEnd Results cancer registryRetrospective cohort studyVTE ratesCohort studyCancer RegistrySurvival analysisPatientsCancer diagnosisCancerFirst yearRisk heterogeneityRiskThromboembolismComorbiditiesRegistryLungColonProstatePancreasBreastEpidemiology
2008
Investigation of 89 candidate gene variants for effects on all-cause mortality following acute coronary syndrome
Morgan TM, Xiao L, Lyons P, Kassebaum B, Krumholz HM, Spertus JA. Investigation of 89 candidate gene variants for effects on all-cause mortality following acute coronary syndrome. BMC Medical Genomics 2008, 9: 66. PMID: 18620593, PMCID: PMC2483267, DOI: 10.1186/1471-2350-9-66.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeRisk factorsACS mortalityCoronary syndromeTraditional cardiac risk factorsKaplan-Meier survival analysisMultivariate risk prediction modelCardiac risk factorsPutative genetic risk factorsGene variantsUniversity-affiliated hospitalBorderline statistical significanceGenetic risk factorsSystematic literature searchRisk prediction modelGenetic variantsCandidate gene variantsACS survivorsCause mortalityACS casesCox regressionPatient cohortClinical prognosisPotential confoundingSurvival analysis
2006
Impact of Medication Therapy Discontinuation on Mortality After Myocardial Infarction
Ho PM, Spertus JA, Masoudi FA, Reid KJ, Peterson ED, Magid DJ, Krumholz HM, Rumsfeld JS. Impact of Medication Therapy Discontinuation on Mortality After Myocardial Infarction. JAMA Internal Medicine 2006, 166: 1842-1847. PMID: 17000940, DOI: 10.1001/archinte.166.17.1842.Peer-Reviewed Original ResearchConceptsTherapy discontinuationMyocardial infarctionEvidence-based medicationsMulticenter prospective cohortUse of aspirinMultivariable survival analysisTransitions of careDiscontinuation of useProspective registryMortality benefitProspective cohortMultivariable analysisOutpatient settingMI hospitalizationDiscontinuationMortality riskMedicationsPatientsSurvival analysisHigh mortalityMortalityTreatment factorsMonthsInfarctionAspirin