2021
Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival
Yang DX, Khera R, Miccio JA, Jairam V, Chang E, Yu JB, Park HS, Krumholz HM, Aneja S. Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival. JAMA Network Open 2021, 4: e211793. PMID: 33755165, PMCID: PMC7988369, DOI: 10.1001/jamanetworkopen.2021.1793.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseNon-small cell lung cancerOverall survivalCell lung cancerCancer DatabaseMedical recordsLung cancerProstate cancerBreast cancerPatient recordsComplete dataRetrospective cohort studyCohort studyCancer RegistryCommon cancerVariables of interestHigh prevalenceMAIN OUTCOMEPatientsClinical advancementReal-world data sourcesCancerPrevalenceSurvivalHeterogeneous differences
2019
Association Between Hospital Recognition for Resuscitation Guideline Adherence and Rates of Survival for In-Hospital Cardiac Arrest
Khera R, Tang Y, Link MS, Krumholz HM, Girotra S, Chan PS. Association Between Hospital Recognition for Resuscitation Guideline Adherence and Rates of Survival for In-Hospital Cardiac Arrest. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005429. PMID: 30871337, PMCID: PMC6592630, DOI: 10.1161/circoutcomes.118.005429.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAwards and PrizesFemaleGuideline AdherenceHeart ArrestHospital MortalityHospitalsHumansInpatientsMaleMiddle AgedOutcome and Process Assessment, Health CarePatient DischargePractice Guidelines as TopicPractice Patterns, Physicians'Quality Indicators, Health CareRegistriesResuscitationTime FactorsTime-to-TreatmentTreatment OutcomeUnited StatesYoung AdultConceptsHospital cardiac arrestCardiac arrestRate of survivalSpontaneous circulationIn-Hospital Cardiac ArrestGuidelines-Resuscitation registryCardiac arrest survivalEndotracheal tube placementHigh rateHospital performanceBest tertileGuidelines-ResuscitationNational GetGuideline adherenceOverall survivalBackground HospitalTube placementNational registryChest compressionsResuscitation qualityHospitalHospital recognitionAward statusSurvivalWeak association
2016
Life Expectancy after Myocardial Infarction, According to Hospital Performance
Bucholz EM, Butala NM, Ma S, Normand ST, Krumholz HM. Life Expectancy after Myocardial Infarction, According to Hospital Performance. New England Journal Of Medicine 2016, 375: 1332-1342. PMID: 27705249, PMCID: PMC5118048, DOI: 10.1056/nejmoa1513223.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionRisk-standardized mortality ratesMyocardial infarctionLife expectancyMortality rateHospital performanceCooperative Cardiovascular ProjectProportional hazards modelLong-term survivalCase-mix severityLonger life expectancySurvival benefitInfarctionMedicare beneficiariesPatientsHospital case mixCase mixHospitalSurvival curvesQuintileStudy sampleSignificant differencesEarly survivalExpectancySurvival
2012
Trends in Survival after In-Hospital Cardiac Arrest
Girotra S, Nallamothu BK, Spertus JA, Li Y, Krumholz HM, Chan PS. Trends in Survival after In-Hospital Cardiac Arrest. New England Journal Of Medicine 2012, 367: 1912-1920. PMID: 23150959, PMCID: PMC3517894, DOI: 10.1056/nejmoa1109148.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestPulseless electrical activityCardiac arrestRisk-adjusted ratesNeurologic disabilityIn-Hospital Cardiac ArrestAcute resuscitation survivalGuidelines-Resuscitation registrySignificant neurologic disabilityQuality improvement registryPulseless ventricular tachycardiaElectrical activityInitial rhythmNeurologic outcomePostresuscitation careAcute resuscitationNeurologic functionSurvival improvementPostresuscitation survivalResuscitation careVentricular tachycardiaRhythm groupVentricular fibrillationMultivariable regressionSurvivalDuration of resuscitation efforts and survival after in-hospital cardiac arrest: an observational study
Goldberger ZD, Chan PS, Berg RA, Kronick SL, Cooke CR, Lu M, Banerjee M, Hayward RA, Krumholz HM, Nallamothu BK, Investigators F. Duration of resuscitation efforts and survival after in-hospital cardiac arrest: an observational study. The Lancet 2012, 380: 1473-1481. PMID: 22958912, PMCID: PMC3535188, DOI: 10.1016/s0140-6736(12)60862-9.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestSpontaneous circulationCardiac arrestResuscitation attemptsMedian durationResuscitation effortsGuidelines-Resuscitation registryDuration of resuscitationRisk-adjusted survivalHigh-risk populationAmerican Heart AssociationPrimary endpointHospital dischargeHeart AssociationObservational studyPatientsUS hospitalsClinical Scholars ProgramSurvival rateHospitalResuscitationHigher survival rateSurvivalNational InstituteHigher likelihood
2009
Hospital Variation in Time to Defibrillation After In-Hospital Cardiac Arrest
Chan PS, Nichol G, Krumholz HM, Spertus JA, Nallamothu BK. Hospital Variation in Time to Defibrillation After In-Hospital Cardiac Arrest. JAMA Internal Medicine 2009, 169: 1265-1273. PMID: 19636027, DOI: 10.1001/archinternmed.2009.196.Peer-Reviewed Original ResearchConceptsCardiac arrestHospital factorsHospital variationIn-Hospital Cardiac ArrestHospital-level effectsHospital cardiac arrestWorse survivalImproved survivalPatient factorsAdult inpatientsHospital predictorsNational registryHospital ratesCardiopulmonary resuscitationGreater oddsIdentical covariatesDefibrillation delaysHospitalDefibrillationDefibrillation timeSurvivalArrestWide variationPatientsInpatients
2008
Delayed Time to Defibrillation after In-Hospital Cardiac Arrest
S. C, M. K, Graham N, K. N, Investigators T. Delayed Time to Defibrillation after In-Hospital Cardiac Arrest. New England Journal Of Medicine 2008, 358: 9-17. PMID: 18172170, DOI: 10.1056/nejmoa0706467.Peer-Reviewed Original ResearchMeSH KeywordsAgedComorbidityElectric CountershockFemaleHeart ArrestHeart FailureHospital Bed CapacityHospital MortalityHospitalizationHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionRetrospective StudiesSurvival AnalysisTachycardia, VentricularTime FactorsVentricular FibrillationConceptsHospital cardiac arrestCardiac arrestHospital dischargeIn-Hospital Cardiac ArrestOverall median timePulseless ventricular tachycardiaMultivariable logistic regressionLower ratesMedian timeVentricular arrhythmiasBlack raceHospital characteristicsNational registryVentricular tachycardiaCardiopulmonary resuscitationExpert guidelinesVentricular fibrillationHospital unitsLogistic regressionPatientsDefibrillationSurvivalArrestHospitalMinutes of delay
2005
77 ADMISSION BODY TEMPERATURE AND MORTALITY IN PATIENTS HOSPITALIZED FOR HEART FAILURE
Nallamothu B, Payvar S, Wang Y, Kosiborod M, Foody J, Masoudi F, Havranek E, Casscells S, Krumholz H. 77 ADMISSION BODY TEMPERATURE AND MORTALITY IN PATIENTS HOSPITALIZED FOR HEART FAILURE. Journal Of Investigative Medicine 2005, 53: s400. DOI: 10.2310/6650.2005.00205.76.Peer-Reviewed Original ResearchOne-year mortalityAdmission body temperatureHeart failureWorse survivalBody temperatureLow body temperatureLogistic regressionPatients 65 yearsAdvanced heart failurePATIENTS HOSPITALIZEDHospital deathMultivariate adjustmentPatient subgroupsIndependent associationClinical dataStudy populationPatientsPolynomial logistic regressionCare ProjectMortalityHospitalSurvivalFailureSignificant relationshipHospitalized
2000
Long-term Outcome of Myocardial Infarction in Women and Men: A Population Perspective
Vaccarino V, Berkman LF, Krumholz HM. Long-term Outcome of Myocardial Infarction in Women and Men: A Population Perspective. American Journal Of Epidemiology 2000, 152: 965-973. PMID: 11092438, DOI: 10.1093/aje/152.10.965.Peer-Reviewed Original ResearchConceptsMyocardial infarctionSurvival advantageImpact of MIMultivariable-adjusted hazard ratiosWomen's survival advantageLong-term mortalityLong-term outcomesPresence of MIAbsence of MISurvival of personsProportional hazards modelPopulation perspectiveTime-dependent covariablesFatal infarctionHazard ratioSame followElderly cohortMI hospitalizationMI casesHazards modelGreater riskInfarctionWomenMenSurvival