2008
An early invasive strategy versus ischemia-guided management after fibrinolytic therapy for ST-segment elevation myocardial infarction: A meta-analysis of contemporary randomized controlled trials
Wijeysundera HC, You JJ, Nallamothu BK, Krumholz HM, Cantor WJ, Ko DT. An early invasive strategy versus ischemia-guided management after fibrinolytic therapy for ST-segment elevation myocardial infarction: A meta-analysis of contemporary randomized controlled trials. American Heart Journal 2008, 156: 564-572.e2. PMID: 18760142, DOI: 10.1016/j.ahj.2008.04.024.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryCardiac CatheterizationElectrocardiographyFemaleFibrinolytic AgentsHemorrhageHumansInjections, IntravenousInpatientsMaleMiddle AgedMyocardial InfarctionMyocardial IschemiaMyocardial ReperfusionRandomized Controlled Trials as TopicRecurrenceStentsStrokeThrombolytic TherapyConceptsST-segment elevation myocardial infarctionEarly invasive strategyPercutaneous coronary interventionElevation myocardial infarctionFibrinolytic therapyInvasive strategyMajor bleedingSTEMI patientsMyocardial infarctionHospital major bleedingIntravenous fibrinolytic therapyLarge randomized trialsRisk of strokeSignificant reductionCause mortalityEligible trialsCoronary interventionRandomized trialsContemporary trialsStent useInclusion criteriaPatientsReinfarctionTherapyTrials
2007
Rescue Angioplasty or Repeat Fibrinolysis After Failed Fibrinolytic Therapy for ST-Segment Myocardial Infarction A Meta-Analysis of Randomized Trials
Wijeysundera HC, Vijayaraghavan R, Nallamothu BK, Foody JM, Krumholz HM, Phillips CO, Kashani A, You JJ, Tu JV, Ko DT. Rescue Angioplasty or Repeat Fibrinolysis After Failed Fibrinolytic Therapy for ST-Segment Myocardial Infarction A Meta-Analysis of Randomized Trials. Journal Of The American College Of Cardiology 2007, 49: 422-430. PMID: 17258087, DOI: 10.1016/j.jacc.2006.09.033.Peer-Reviewed Original ResearchConceptsRescue percutaneous coronary interventionPercutaneous coronary interventionST-segment myocardial infarctionFibrinolytic therapyCause mortalityMinor bleedingRandomized trialsRisk of strokeSignificant clinical improvementImproved clinical outcomesSignificant risk reductionFixed-effects modelRescue angioplastySTEMI patientsClinical improvementConservative managementConservative treatmentCoronary interventionHospital dischargeHeart failureClinical outcomesMyocardial infarctionBest therapyCommon treatmentPatients
2006
Effect of Door-to-Balloon Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction
McNamara RL, Wang Y, Herrin J, Curtis JP, Bradley EH, Magid DJ, Peterson ED, Blaney M, Frederick PD, Krumholz HM, Investigators N. Effect of Door-to-Balloon Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction. Journal Of The American College Of Cardiology 2006, 47: 2180-2186. PMID: 16750682, DOI: 10.1016/j.jacc.2005.12.072.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionST-segment elevation myocardial infarctionBalloon timeElevation myocardial infarctionSymptom onsetMyocardial infarctionHospital mortalityPatient characteristicsDoor timeEffect of doorPrimary PCIBaseline risk statusPercutaneous coronary interventionHigh-risk factorsSTEMI patientsCohort studyCoronary interventionLonger doorEntire cohortSubgroup analysisNational registryBaseline riskMortality riskPatientsMortalityRegionalization of ST-Segment Elevation Acute Coronary Syndromes Care Putting a National Policy in Proper Perspective
Rathore SS, Epstein AJ, Nallamothu BK, Krumholz HM. Regionalization of ST-Segment Elevation Acute Coronary Syndromes Care Putting a National Policy in Proper Perspective. Journal Of The American College Of Cardiology 2006, 47: 1346-1349. PMID: 16580519, PMCID: PMC2789345, DOI: 10.1016/j.jacc.2005.11.053.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCISTEMI patientsFibrinolytic therapyPCI hospitalsST-segment elevation myocardial infarction (STEMI) careAcute coronary syndrome careHigh-volume PCI hospitalsHigh-risk STEMI patientsElevation Myocardial Infarction CareHigh-volume hospitalsLow-volume hospitalsPercutaneous coronary interventionMyocardial infarction careCardiac care facilitiesHealth care resourcesHealth care systemInitial hospitalPCI patientsCoronary interventionU.S. health care systemAverage patientSingle deathCare facilitiesPatientsRelation Between Hospital Specialization With Primary Percutaneous Coronary Intervention and Clinical Outcomes in ST-Segment Elevation Myocardial Infarction
Nallamothu BK, Wang Y, Magid DJ, McNamara RL, Herrin J, Bradley EH, Bates ER, Pollack CV, Krumholz HM. Relation Between Hospital Specialization With Primary Percutaneous Coronary Intervention and Clinical Outcomes in ST-Segment Elevation Myocardial Infarction. Circulation 2006, 113: 222-229. PMID: 16401769, DOI: 10.1161/circulationaha.105.578195.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionHospital mortalityBalloon timePPCI volumeFibrinolytic therapyClinical outcomesMyocardial infarctionPrimary percutaneous coronary intervention capabilityPercutaneous coronary intervention capabilityPrimary percutaneous coronary interventionHierarchical multivariable regressionMyocardial infarction 4Hospital-level factorsPercutaneous coronary interventionHospital specializationSTEMI patientsCoronary interventionHighest quartileShorter doorHospital characteristicsNational registryLowest quartileRelative riskMultivariable regression