2007
Renal Impairment Predicts Long-Term Mortality Risk after Acute Myocardial Infarction
Smith GL, Masoudi FA, Shlipak MG, Krumholz HM, Parikh CR. Renal Impairment Predicts Long-Term Mortality Risk after Acute Myocardial Infarction. Journal Of The American Society Of Nephrology 2007, 19: 141-150. PMID: 18003773, PMCID: PMC2391037, DOI: 10.1681/asn.2007050554.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionRenal functionRenal impairmentCreatinine clearanceMortality riskMyocardial infarctionCockcroft-Gault creatinine clearanceLong-term mortality riskMild renal impairmentSevere renal impairmentNormal renal functionCohort of patientsCooperative Cardiovascular ProjectPatient ageSystolic functionHospitalized patientsPrognostic importanceRisk factorsPatientsMortalityImpairmentClearanceGFRInfarctionRiskThe Prognostic Importance of a Small Acute Decrement in Kidney Function in Hospitalized Patients: A Systematic Review and Meta-Analysis
Coca SG, Peixoto AJ, Garg AX, Krumholz HM, Parikh CR. The Prognostic Importance of a Small Acute Decrement in Kidney Function in Hospitalized Patients: A Systematic Review and Meta-Analysis. American Journal Of Kidney Diseases 2007, 50: 712-720. PMID: 17954284, DOI: 10.1053/j.ajkd.2007.07.018.Peer-Reviewed Original ResearchConceptsSerum creatinine levelsCreatinine levelsRelative riskTerm mortalityAcute changesWorse short-term outcomesClinical settingRR of deathAcute kidney injuryObservational cohort studyShort-term outcomesGreater relative riskPercentage of changeAcute decrementsKidney injuryCohort studyRenal functionHospitalized patientsKidney functionPrognostic importanceEmbase databasesWorse outcomesAcute decreaseStatistical heterogeneityAbstractTextAdverse Effects of Combination Angiotensin II Receptor Blockers Plus Angiotensin-Converting Enzyme Inhibitors for Left Ventricular Dysfunction: A Quantitative Review of Data From Randomized Clinical Trials
Phillips CO, Kashani A, Ko DK, Francis G, Krumholz HM. Adverse Effects of Combination Angiotensin II Receptor Blockers Plus Angiotensin-Converting Enzyme Inhibitors for Left Ventricular Dysfunction: A Quantitative Review of Data From Randomized Clinical Trials. JAMA Internal Medicine 2007, 167: 1930-1936. PMID: 17923591, DOI: 10.1001/archinte.167.18.1930.Peer-Reviewed Original ResearchConceptsAngiotensin II receptor blockersSymptomatic left ventricular dysfunctionLeft ventricular dysfunctionII receptor blockersVentricular dysfunctionAdverse effectsMedication discontinuationReceptor blockersSymptomatic hypotensionRenal functionACE inhibitorsClinical trialsRelative riskEnzyme inhibitorsAngiotensin converting enzyme (ACE) inhibitorsACE inhibitor therapyHealth clinical trialsChronic heart failureRandomized clinical trialsAcute myocardial infarctionConfidence intervalsRandom-effects modelSignificant increaseEligible RCTsHeart failure
2006
Underrepresentation of Renal Disease in Randomized Controlled Trials of Cardiovascular Disease
Coca SG, Krumholz HM, Garg AX, Parikh CR. Underrepresentation of Renal Disease in Randomized Controlled Trials of Cardiovascular Disease. JAMA 2006, 296: 1377-1384. PMID: 16985230, DOI: 10.1001/jama.296.11.1377.Peer-Reviewed Original ResearchConceptsChronic congestive heart failureCongestive heart failureRenal diseaseRenal functionHeart failureSubgroup analysisCardiovascular diseaseCardiology/American Heart Association guidelinesAmerican Heart Association guidelinesAldosterone system antagonistsBaseline renal functionHeart Association guidelinesCardiovascular disease trialsCurrent American CollegeRandomized Controlled TrialsAcute myocardial infarctionEffects of interventionsRepresentation of patientsOriginal articlesBaseline characteristicsCardiovascular mortalityPatient characteristicsControlled TrialsPrognostic featuresMyocardial infarctionIncrease in Creatinine and Cardiovascular Risk in Patients with Systolic Dysfunction after Myocardial Infarction
Jose P, Skali H, Anavekar N, Tomson C, Krumholz HM, Rouleau JL, Moye L, Pfeffer MA, Solomon SD, Investigators F. Increase in Creatinine and Cardiovascular Risk in Patients with Systolic Dysfunction after Myocardial Infarction. Journal Of The American Society Of Nephrology 2006, 17: 2886-2891. PMID: 16928807, DOI: 10.1681/asn.2006010063.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionCaptopril groupCardiovascular riskRenal functionSerum creatininePotent independent risk factorVentricular Enlargement (SAVE) trialBaseline renal functionHeart failure populationComposite end pointIndependent risk factorSerum creatinine measurementsBaseline creatinineCardiovascular deathCardiovascular morbidityPlacebo groupRenal dysfunctionSystolic dysfunctionVentricular dysfunctionAdverse eventsPrognostic importanceFailure populationTherapeutic choiceRisk factorsSerum Urea Nitrogen, Creatinine, and Estimators of Renal Function: Mortality in Older Patients With Cardiovascular Disease
Smith GL, Shlipak MG, Havranek EP, Foody JM, Masoudi FA, Rathore SS, Krumholz HM. Serum Urea Nitrogen, Creatinine, and Estimators of Renal Function: Mortality in Older Patients With Cardiovascular Disease. JAMA Internal Medicine 2006, 166: 1134-1142. PMID: 16717177, DOI: 10.1001/archinte.166.10.1134.Peer-Reviewed Original ResearchConceptsCreatinine levelsMyocardial infarctionHeart failureMDRD eGFRCardiovascular patientsSerum urea nitrogen levelsOlder cardiovascular patientsHeart failure patientsModification of DietGlomerular filtration rateUrea nitrogen levelsProportional hazards modelSerum urea nitrogenML/minMagnitude of riskRenal measuresPostdischarge mortalityRenal dysfunctionOlder patientsRenal functionFailure patientsOutcome prognosticationRetrospective cohortFiltration rateCardiovascular diseaseRenal Impairment and Outcomes in Heart Failure Systematic Review and Meta-Analysis
Smith GL, Lichtman JH, Bracken MB, Shlipak MG, Phillips CO, DiCapua P, Krumholz HM. Renal Impairment and Outcomes in Heart Failure Systematic Review and Meta-Analysis. Journal Of The American College Of Cardiology 2006, 47: 1987-1996. PMID: 16697315, DOI: 10.1016/j.jacc.2005.11.084.Peer-Reviewed Original ResearchConceptsRenal impairmentHF patientsSevere impairmentRenal functionExcess mortalityMortality riskSystematic reviewAssociated mortality riskHeart failure patientsCause mortality riskPrecise risk estimatesCause mortalityFailure patientsDL increaseRisk stratificationTherapeutic strategiesPatientsMeta-AnalysisMortalityRisk estimatesImpairmentSystematic searchMin decreaseRiskCreatinine
2005
Race and Renal Impairment in Heart Failure
Smith GL, Shlipak MG, Havranek EP, Masoudi FA, McClellan WM, Foody JM, Rathore SS, Krumholz HM. Race and Renal Impairment in Heart Failure. Circulation 2005, 111: 1270-1277. PMID: 15769768, DOI: 10.1161/01.cir.0000158131.78881.d5.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkersBlack or African AmericanCohort StudiesComorbidityCreatinineDiabetes MellitusFemaleGlomerular Filtration RateHeart FailureHumansHypertensionInpatientsKidney DiseasesMaleMedicareMortalityMyocardial InfarctionPrognosisRetrospective StudiesRisk FactorsTreatment OutcomeWhite PeopleConceptsRenal impairmentHF patientsWhite patientsMortality riskRacial differencesElderly HF patientsSimilar racial differencesGlomerular filtration rateHeart failure patientsStriking racial disparitiesMagnitude of riskDistinct morbidityElevated creatinineFailure patientsRenal functionHeart failureHigher creatinineRenal diseaseBlack patientsOptimal therapyPrognostic indicatorFiltration rateMedicare patientsMortality burdenRepresentative cohort
2004
Renal Function, Digoxin Therapy, and Heart Failure Outcomes: Evidence from the Digoxin Intervention Group Trial
SHLIPAK MG, SMITH GL, RATHORE SS, MASSIE BM, KRUMHOLZ HM. Renal Function, Digoxin Therapy, and Heart Failure Outcomes: Evidence from the Digoxin Intervention Group Trial. Journal Of The American Society Of Nephrology 2004, 15: 2195-2203. PMID: 15284305, DOI: 10.1097/01.asn.0000135121.81744.75.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateHeart failure outcomesEffect of digoxinRenal functionHeart failureRenal dysfunctionGroup trialsMortality riskLow glomerular filtration rateLevel of GFRFailure outcomesSystolic heart failureHeart failure survivalLower mortality hazardDigoxin efficacyCause mortalityDigoxin therapyCommon complicationClinical outcomesFiltration rateGFR 60Failure survivalSimilar riskMortality hazardStable outpatientsRelationship between heart failure treatment and development of worsening renal function among hospitalized patients11Guest Editor for this manuscript was Peter M. Okin, MD, New York Hosptial-Cornell Medical Center, New York, NY.
Butler J, Forman DE, Abraham WT, Gottlieb SS, Loh E, Massie BM, O'Connor CM, Rich MW, Stevenson LW, Wang Y, Young JB, Krumholz HM. Relationship between heart failure treatment and development of worsening renal function among hospitalized patients11Guest Editor for this manuscript was Peter M. Okin, MD, New York Hosptial-Cornell Medical Center, New York, NY. American Heart Journal 2004, 147: 331-338. PMID: 14760333, DOI: 10.1016/j.ahj.2003.08.012.Peer-Reviewed Original ResearchConceptsFluid intake/outputHeart failureIntake/outputRenal functionHigh riskCalcium channel blocker useHistory of HFAssociation of medicationLoop diuretic dosesPredictors of WRFElevated creatinine levelEnzyme inhibitor useHeart failure treatmentCase-control studyUse of CCBGreater fluid lossHigher hematocrit levelsUncontrolled hypertensionBlocker useDiuretic dosesCreatinine levelsInhibitor useAcute treatmentDiabetes mellitusIndependent predictorsIncidence, predictors at admission, and impact of worsening renal function among patients hospitalized with heart failure
Forman DE, Butler J, Wang Y, Abraham WT, O'Connor CM, Gottlieb SS, Loh E, Massie BM, Rich MW, Stevenson LW, Young JB, Krumholz HM. Incidence, predictors at admission, and impact of worsening renal function among patients hospitalized with heart failure. Journal Of The American College Of Cardiology 2004, 43: 61-67. PMID: 14715185, DOI: 10.1016/j.jacc.2003.07.031.Peer-Reviewed Original ResearchConceptsRenal functionHF patientsHospitalized heart failure patientsHistory of HFChronic HF patientsDay of admissionHeart failure patientsLength of hospitalizationSystolic blood pressureRelative risk ratiosAssociation of developmentMajority of casesRegression model analysisAdmission creatinineHospital deathHospital outcomesChart reviewClinical characteristicsFailure patientsSerum creatinineBlood pressureClinical predictorsConsecutive patientsDiabetes mellitusHeart failure
2003
Worsening renal function: What is a clinically meaningful change in creatinine during hospitalization with heart failure?
Smith GL, Vaccarino V, Kosiborod M, Lichtman JH, Cheng S, Watnick SG, Krumholz HM. Worsening renal function: What is a clinically meaningful change in creatinine during hospitalization with heart failure? Journal Of Cardiac Failure 2003, 9: 13-25. PMID: 12612868, DOI: 10.1054/jcaf.2003.3.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersCohort StudiesConnecticutCreatinineFemaleFollow-Up StudiesHeart FailureHospitalizationHumansKidney DiseasesKidney Function TestsMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsProspective StudiesRisk FactorsSensitivity and SpecificityStatistics as TopicStroke VolumeSurvival AnalysisConceptsCreatinine elevationRenal functionHeart failureAdverse outcomesRisk of deathNumber of patientsMagnitude of riskBaseline creatinineProspective cohortRisk factorsFunctional declineHigh riskPatientsCreatinineMortalityHospitalizationDeathDlImportant predictorRiskElevationMeaningful changeMaximum specificityOutcomesBetter definition
2002
The prognostic importance of different definitions of worsening renal function in congestive heart failure
Gottlieb SS, Abraham W, Butler J, Forman DE, Loh E, Massie BM, O'Connor CM, Rich MW, Stevenson LW, Young J, Krumholz HM. The prognostic importance of different definitions of worsening renal function in congestive heart failure. Journal Of Cardiac Failure 2002, 8: 136-141. PMID: 12140805, DOI: 10.1054/jcaf.2002.125289.Peer-Reviewed Original ResearchConceptsCongestive heart failureRenal functionLength of stayHeart failurePrognostic importanceDepressed ejection fractionProlonged hospital stayFinal creatinineHospital mortalityHospital stayRenal failureSerum creatinineDL increaseEjection fractionACE inhibitorsPoor prognosisPatient populationWorse outcomesPrior historyTherapeutic interventionsCreatinineStayPatientsMortalityDlWorsening renal function: what is a clinically meaningful change in creatinine during hospitalization with heart failure?
Smith G, Vaccarino V, Kosiborod M, Lichtman J, Cheng S, Krumholz H. Worsening renal function: what is a clinically meaningful change in creatinine during hospitalization with heart failure? Journal Of The American College Of Cardiology 2002, 39: 461. DOI: 10.1016/s0735-1097(02)82070-8.Peer-Reviewed Original Research
2000
Correlates and impact on outcomes of worsening renal function in patients ≥65 years of age with heart failure
Krumholz H, Chen Y, Vaccarino V, Wang Y, Radford M, Bradford W, Horwitz R. Correlates and impact on outcomes of worsening renal function in patients ≥65 years of age with heart failure. The American Journal Of Cardiology 2000, 85: 1110-1113. PMID: 10781761, DOI: 10.1016/s0002-9149(00)00705-0.Peer-Reviewed Original Research