2024
Racial Differences in 1-Year Mortality after Hospitalization for Chronic Obstructive Pulmonary Disease in the United States.
Jain S, Priya A, Pekow P, Spitzer K, Walkey A, Opara I, Krumholz H, Lindenauer P. Racial Differences in 1-Year Mortality after Hospitalization for Chronic Obstructive Pulmonary Disease in the United States. Annals Of The American Thoracic Society 2024, 21: 585-594. PMID: 37943953, PMCID: PMC10995557, DOI: 10.1513/annalsats.202304-359oc.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseChronic obstructive pulmonary disease hospitalizationsObstructive pulmonary diseaseMedicare beneficiariesWhite racePulmonary diseaseChronic obstructive pulmonary disease exacerbationsChronic obstructive pulmonary disease patientsObstructive pulmonary disease exacerbationsObstructive pulmonary disease patientsHospital-level clusteringPulmonary disease exacerbationsRetrospective cohort studyPulmonary disease patientsCox regression modelIndividual socioeconomic statusDisease exacerbationPulmonary rehabilitationCohort studyDischarge dispositionOverall mortalityIllness severityHospitalized populationCare factorsDisease patients
2017
Inferior Vena Cava Filters to Prevent Pulmonary Embolism Systematic Review and Meta-Analysis
Bikdeli B, Chatterjee S, Desai NR, Kirtane AJ, Desai MM, Bracken MB, Spencer FA, Monreal M, Goldhaber SZ, Krumholz HM. Inferior Vena Cava Filters to Prevent Pulmonary Embolism Systematic Review and Meta-Analysis. Journal Of The American College Of Cardiology 2017, 70: 1587-1597. PMID: 28935036, PMCID: PMC8412839, DOI: 10.1016/j.jacc.2017.07.775.Peer-Reviewed Original ResearchConceptsDeep vein thrombosisSubsequent pulmonary embolismInferior vena cava filterPulmonary embolismVena cava filtersIVC filtersCause mortalityOdds ratioCava filtersSystematic reviewSubsequent deep vein thrombosisInverse variance fixed-effect modelRisk of PECochrane Central RegisterQuality of evidenceFixed-effects modelCentral RegisterVein thrombosisControlled TrialsOverall mortalityObservational studyMAIN OUTCOMEPrimary analysisMeta-AnalysisMortality
2009
Association of door-to-balloon time and mortality in patients admitted to hospital with ST elevation myocardial infarction: national cohort study
Rathore SS, Curtis JP, Chen J, Wang Y, Nallamothu BK, Epstein AJ, Krumholz HM, Registry F. Association of door-to-balloon time and mortality in patients admitted to hospital with ST elevation myocardial infarction: national cohort study. The BMJ 2009, 338: b1807. PMID: 19454739, PMCID: PMC2684578, DOI: 10.1136/bmj.b1807.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionST-elevation myocardial infarctionElevation myocardial infarctionPercutaneous coronary interventionBalloon timeCoronary interventionMyocardial infarctionCohort studyLower mortalityMultivariable logistic regression modelAssociation of doorIncremental mortality benefitProspective cohort studyNational cohort studyAcute care hospitalsLogistic regression modelsFractional polynomial modelsAdjusted riskLonger doorMedian doorMortality benefitCare hospitalOverall mortalityMAIN OUTCOMEAmerican College
2008
Systolic Function as a Predictor of Mortality and Quality of Life in Long‐term Survivors with Heart Failure
McNamara R, Austin B, Wang Y, Smith G, Vaccarine V, Krumholz H. Systolic Function as a Predictor of Mortality and Quality of Life in Long‐term Survivors with Heart Failure. Clinical Cardiology 2008, 31: 119-124. PMID: 18383045, PMCID: PMC6653267, DOI: 10.1002/clc.20118.Peer-Reviewed Original ResearchConceptsQuality of lifeEjection fractionHeart failureLong-term survivorsFunctional declineSystolic functionKansas City Cardiomyopathy Questionnaire scoreModest survival advantageReduced ejection fractionDaily living scoreDisease-related qualityPredictors of mortalityHeart failure patientsClinical summary scoreLong-term survivalHigh mortality rateKCCQ scoresRenal insufficiencyFailure patientsLiving scoreDiabetes mellitusOverall mortalityPrimary outcomeLimitation scoresQOL scores
2002
Sex-Based Differences in the Effect of Digoxin for the Treatment of Heart Failure
Rathore SS, Wang Y, Krumholz HM. Sex-Based Differences in the Effect of Digoxin for the Treatment of Heart Failure. New England Journal Of Medicine 2002, 347: 1403-1411. PMID: 12409542, DOI: 10.1056/nejmoa021266.Peer-Reviewed Original ResearchConceptsEffect of digoxinDepressed left ventricular systolic functionLeft ventricular systolic functionVentricular systolic functionSex-based differencesRate of deathDigoxin therapyHeart failureSystolic functionMultivariable Cox proportional hazards modelsDigitalis Investigation Group (DIG) studyDigitalis Investigation Group trialCox proportional hazards modelHeart failure variesPrimary end pointRisk of deathProportional hazards modelMantel-Haenszel testOverall mortalityTherapy differsEpidemiologic featuresMultivariable analysisClinical variablesSubgroup analysisGroup trials
2000
Pulse pressure and risk for myocardial infarction and heart failure in the elderly
Vaccarino V, Holford T, Krumholz H. Pulse pressure and risk for myocardial infarction and heart failure in the elderly. Journal Of The American College Of Cardiology 2000, 36: 130-138. PMID: 10898424, DOI: 10.1016/s0735-1097(00)00687-2.Peer-Reviewed Original ResearchConceptsCongestive heart failureCoronary heart diseaseSystolic blood pressureCardiovascular end pointsDiastolic blood pressurePulse pressureBlood pressureEnd pointHeart failureIndependent predictorsOverall mortalityIncidence of CHFIncidence of CHDEffect of PPElevated systolic blood pressureCurrent hypertension guidelinesIncident CHF eventsCHD risk factorsCurrent medication useIncident CHD eventsPowerful independent predictorBlood pressure parametersBlood pressure variablesElevated pulse pressureDiastolic hypertension
1996
Sex Differences in Survival After Myocardial Infarction in Older Adults: A Community‐Based Approach
Vaccarino V, Krumholz H, de Leon C, Holford T, Seeman T, Horwitz R, Berkman L. Sex Differences in Survival After Myocardial Infarction in Older Adults: A Community‐Based Approach. Journal Of The American Geriatrics Society 1996, 44: 1174-1182. PMID: 8855995, DOI: 10.1111/j.1532-5415.1996.tb01366.x.Peer-Reviewed Original ResearchConceptsMyocardial infarctionMultivariable adjustmentClinical severityRelative riskPsychosocial factorsOlder individualsProspective cohort studyMain outcome measuresDemographic factorsSex differencesHospital complicationsCause mortalityLate mortalityClinical characteristicsCohort studyCT cohortHospital admissionOverall mortalityEarly mortalityElderly ProgramMean agePhysical functionFunctional statusMedical recordsOutcome measures