2020
Comparison of Cardiovascular and Safety Outcomes of Chlorthalidone vs Hydrochlorothiazide to Treat Hypertension
Hripcsak G, Suchard MA, Shea S, Chen R, You SC, Pratt N, Madigan D, Krumholz HM, Ryan PB, Schuemie MJ. Comparison of Cardiovascular and Safety Outcomes of Chlorthalidone vs Hydrochlorothiazide to Treat Hypertension. JAMA Internal Medicine 2020, 180: 542-551. PMID: 32065600, PMCID: PMC7042845, DOI: 10.1001/jamainternmed.2019.7454.Peer-Reviewed Original ResearchConceptsComposite outcome eventsHeart failureMyocardial infarctionOutcome eventsSafety outcomesComposite cardiovascular disease outcomeLarge-scale Evidence GenerationType 2 diabetes mellitusSignificant cardiovascular benefitsAcute renal failureAbnormal weight gainChronic kidney diseaseComposite cardiovascular outcomeFirst-line therapyAdministrative claims databaseComparative cohort studyCardiovascular disease outcomesSudden cardiac deathInpatient care episodesAcute myocardial infarctionPropensity score stratificationComparison of CardiovascularElectronic health recordsAntihypertensive monotherapyChlorthalidone use
1995
Sex differences in mortality after myocardial infarction. Is there evidence for an increased risk for women?
Vaccarino V, Krumholz H, Berkman L, Horwitz R. Sex differences in mortality after myocardial infarction. Is there evidence for an increased risk for women? Circulation 1995, 91: 1861-71. PMID: 7882498, DOI: 10.1161/01.cir.91.6.1861.Peer-Reviewed Original ResearchConceptsMyocardial infarctionMortality rateIncreased early mortalitySex differencesUnadjusted mortality ratesHigh mortality rateEnglish-language literatureEarly phaseImproved survivalPatient seriesEarly mortalityFemale sexRisk factorsOutcome eventsCrude rateMEDLINE searchInfarctionSurvival rateOlder ageMortalityWomenAgeMenNumber of studiesLower survival