2023
Opportunities and Achievement of Medication Initiation Among Inpatients With Heart Failure With Reduced Ejection Fraction
Swat S, Xu H, Allen L, Greene S, DeVore A, Matsouaka R, Goyal P, Peterson P, Hernandez A, Krumholz H, Yancy C, Fonarow G, Hess P, Program A. Opportunities and Achievement of Medication Initiation Among Inpatients With Heart Failure With Reduced Ejection Fraction. JACC Heart Failure 2023, 11: 918-929. PMID: 37318420, DOI: 10.1016/j.jchf.2023.04.015.Peer-Reviewed Original ResearchConceptsEvidence-based medicationsMedication initiationReduced ejection fractionNumber of medicationsMultivariable logistic regressionNumber of patientsPre-existing conditionsReduced ejectionEjection fractionHeart failureMultivariable analysisFemale sexLower oddsMedicationsMean net gainPatientsRural hospitalsAdmissionOlder ageLogistic regressionStudy periodMean numberOddsInitiationRural locations
2015
National assessment of statin therapy for patients with acute myocardial infarction, 2001–11: insight from the China PEACE-Retrospective Acute Myocardial Infarction study
Zhang L, Li J, Li X, Nasir K, Zhang H, Wu Y, Hu S, Wang Q, Downing N, Desai N, Masoudi F, Spertus J, Krumholz H, Jiang L, Group O. National assessment of statin therapy for patients with acute myocardial infarction, 2001–11: insight from the China PEACE-Retrospective Acute Myocardial Infarction study. The Lancet 2015, 386: s42. DOI: 10.1016/s0140-6736(15)00623-6.Peer-Reviewed Original ResearchIntensive statin therapyAcute myocardial infarctionAcute Myocardial Infarction StudyStatin therapyMyocardial Infarction StudyMyocardial infarctionStatin useCardiovascular diseaseLow-density lipoprotein cholesterolStatin therapy useLong-term mortalityUse of statinsNumber of patientsTwo-stage random sampling designMultilevel logistic regression modelsCochran-Armitage testLogistic regression modelsWestern rural regionStatin regimensEligible patientsHospital mortalityLipoprotein cholesterolFamily Planning CommissionIntensive therapyTherapy use
2014
Relation between door-to-balloon times and mortality after primary percutaneous coronary intervention over time: a retrospective study
Nallamothu BK, Normand SL, Wang Y, Hofer TP, Brush JE, Messenger JC, Bradley EH, Rumsfeld JS, Krumholz HM. Relation between door-to-balloon times and mortality after primary percutaneous coronary intervention over time: a retrospective study. The Lancet 2014, 385: 1114-1122. PMID: 25467573, PMCID: PMC4409657, DOI: 10.1016/s0140-6736(14)61932-2.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionD2B timePercutaneous coronary interventionPopulation of patientsHospital mortalityBalloon timeCoronary interventionRetrospective studyMortality riskNational Cardiovascular Data Registry CathPCI RegistryST-elevation myocardial infarction (STEMI) patientsProcedural factorsStudy periodMyocardial infarction patientsNumber of patientsShorter D2B timesPopulation levelSecular trendsAbsence of associationPrimary PCICathPCI RegistryElderly patientsBlood InstituteEntire cohortAverage doorClinical Trial Evidence Supporting FDA Approval of Novel Therapeutic Agents, 2005-2012
Downing NS, Aminawung JA, Shah ND, Krumholz HM, Ross JS. Clinical Trial Evidence Supporting FDA Approval of Novel Therapeutic Agents, 2005-2012. JAMA 2014, 311: 368-377. PMID: 24449315, PMCID: PMC4144867, DOI: 10.1001/jama.2013.282034.Peer-Reviewed Original ResearchConceptsPivotal efficacy trialsNovel therapeutic agentsClinical trial evidencePivotal trialsEfficacy trialsTherapeutic agentsEnd pointTrial evidenceMedian numberAvailable FDA documentsSingle pivotal trialTrial end pointsSurrogate end pointsNumber of patientsLength of treatmentCross-sectional analysisPrimary outcomeClinical outcomesTrial completion ratesClinical benefitPlacebo comparatorSurrogate outcomesMAIN OUTCOMEDrug AdministrationUS Food
2013
National Trends in Heart Failure Hospitalization After Acute Myocardial Infarction for Medicare Beneficiaries
Chen J, Hsieh AF, Dharmarajan K, Masoudi FA, Krumholz HM. National Trends in Heart Failure Hospitalization After Acute Myocardial Infarction for Medicare Beneficiaries. Circulation 2013, 128: 2577-2584. PMID: 24190958, PMCID: PMC4415510, DOI: 10.1161/circulationaha.113.003668.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHF hospitalizationHeart failureMyocardial infarctionMedicare beneficiariesManagement of AMIHeart failure hospitalizationSubsequent HF hospitalizationNumber of patientsNational trendsHigh-risk conditionsContemporary national trendsRelative annual increaseDemographic factorsFailure hospitalizationPerson yearsClinical comorbiditiesNational sampleComplete national sampleHospitalizationMedicare feeAMI hospitalizationService beneficiariesAnnual declineStudy period
2008
The influence of age on health status outcomes after acute myocardial infarction
Ho PM, Eng MH, Rumsfeld JS, Spertus JA, Peterson PN, Jones PG, Peterson ED, Alexander KP, Havranek EP, Krumholz HM, Masoudi FA. The influence of age on health status outcomes after acute myocardial infarction. American Heart Journal 2008, 155: 855-861. PMID: 18440332, DOI: 10.1016/j.ahj.2007.11.032.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionYears of ageSurvivors of AMIHealth status outcomesOlder patientsBetter HRQLHigh mortalityMyocardial infarctionStatus outcomesSeattle Angina QuestionnaireBaseline health statusHealth-related qualityNumber of patientsInfluence of ageAngina burdenBaseline anginaAngina QuestionnaireAngina symptomsClinical characteristicsProspective cohortYounger patientsMultivariable analysisRisk factorsSpectrum of ageHRQL
2005
Volume-based referral for cardiovascular procedures in the United States: a cross-sectional regression analysis
Epstein AJ, Rathore SS, Krumholz HM, Volpp K. Volume-based referral for cardiovascular procedures in the United States: a cross-sectional regression analysis. BMC Health Services Research 2005, 5: 42. PMID: 15935099, PMCID: PMC1175086, DOI: 10.1186/1472-6963-5-42.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionHigh-volume hospitalsVolume hospitalsLow-volume hospitalsNumber of patientsHospital mortalityCoronary artery bypass graft surgeryLeapfrog GroupArtery bypass graft surgeryNational hospital discharge databaseProcedure-associated mortalityVolume-based referralBypass graft surgeryHospital discharge databaseNumber of deathsCABG patientsHospital CABGGraft surgeryPCI patientsCoronary interventionDischarge databaseRetrospective analysisCABGCardiovascular proceduresPatients
2003
Worsening renal function: What is a clinically meaningful change in creatinine during hospitalization with heart failure?
Smith GL, Vaccarino V, Kosiborod M, Lichtman JH, Cheng S, Watnick SG, Krumholz HM. Worsening renal function: What is a clinically meaningful change in creatinine during hospitalization with heart failure? Journal Of Cardiac Failure 2003, 9: 13-25. PMID: 12612868, DOI: 10.1054/jcaf.2003.3.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersCohort StudiesConnecticutCreatinineFemaleFollow-Up StudiesHeart FailureHospitalizationHumansKidney DiseasesKidney Function TestsMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsProspective StudiesRisk FactorsSensitivity and SpecificityStatistics as TopicStroke VolumeSurvival AnalysisConceptsCreatinine elevationRenal functionHeart failureAdverse outcomesRisk of deathNumber of patientsMagnitude of riskBaseline creatinineProspective cohortRisk factorsFunctional declineHigh riskPatientsCreatinineMortalityHospitalizationDeathDlImportant predictorRiskElevationMeaningful changeMaximum specificityOutcomesBetter definition
2002
β-Blocker Therapy and Symptoms of Depression, Fatigue, and Sexual Dysfunction
Ko DT, Hebert PR, Coffey CS, Sedrakyan A, Curtis JP, Krumholz HM. β-Blocker Therapy and Symptoms of Depression, Fatigue, and Sexual Dysfunction. JAMA 2002, 288: 351-357. PMID: 12117400, DOI: 10.1001/jama.288.3.351.Peer-Reviewed Original ResearchConceptsBeta-blocker therapySexual dysfunctionDepressive symptomsSymptoms of depressionAdverse eventsHeart failureMyocardial infarctionSignificant annual increaseAdditional reportsLipid solubilityAdverse effectsWithdrawal of therapyΒ-blocker therapyPatient-reported symptomsNumber of patientsEnglish-language articlesInclusion of trialsPlacebo groupMortality benefitRandomized trialsStudy treatmentCardiac patientsPlacebo controlRisk of fatigueClinical trials
1999
Variations in and correlates of length of stay in academic hospitals among patients with heart failure resulting from systolic dysfunction.
Krumholz HM, Chen YT, Bradford WD, Cerese J. Variations in and correlates of length of stay in academic hospitals among patients with heart failure resulting from systolic dysfunction. The American Journal Of Managed Care 1999, 5: 715-23. PMID: 10538451.Peer-Reviewed Original ResearchConceptsLength of stayCongestive heart failureHeart failureSystolic dysfunctionPatient characteristicsAcademic hospitalCollaborative quality improvement projectIndividual hospitalsAdmission clinical characteristicsRetrospective cohort studyPrincipal discharge diagnosisNumber of patientsQuality improvement projectUniversity HealthSystem ConsortiumCorrelates of lengthHospital stayPeripheral edemaClinical characteristicsCohort studyRenal failureClinical factorsMajor complicationsHospital eventsRegression modelsAtrial fibrillation