2021
Trends and geographical variation in population thriving, struggling and suffering across the USA, 2008–2017: a retrospective repeated cross-sectional study
Riley C, Herrin J, Lam V, Hamar B, Witters D, Liu D, Krumholz HM, Roy B. Trends and geographical variation in population thriving, struggling and suffering across the USA, 2008–2017: a retrospective repeated cross-sectional study. BMJ Open 2021, 11: e043375. PMID: 34261676, PMCID: PMC8281074, DOI: 10.1136/bmjopen-2020-043375.Peer-Reviewed Original ResearchConceptsPercentage of peopleCross-sectional studyWell-Being IndexMarked geographical variationNational HealthRetrospective analysisUS populationCross-sectional sampleLife evaluationGeographical disparitiesGreater improvementCantril SelfCurrent life satisfactionGeographical variationLife optimismNational averageInterventionConceptions of healthHealthPercentage
2020
Non-inferiority trials using a surrogate marker as the primary endpoint: An increasing phenotype in cardiovascular trials
Bikdeli B, Caraballo C, Welsh J, Ross JS, Kaul S, Stone GW, Krumholz HM. Non-inferiority trials using a surrogate marker as the primary endpoint: An increasing phenotype in cardiovascular trials. Clinical Trials 2020, 17: 723-728. PMID: 32838556, PMCID: PMC8088773, DOI: 10.1177/1740774520949157.Peer-Reviewed Original ResearchConceptsNon-inferiority trialPrimary endpointClinical outcome trialsNon-inferiority marginSurrogate markerNon-inferiority designCardiovascular trialsOutcome trialsClinical outcomesDefinitive clinical outcome trialsNon-inferiority criteriaStudy protocolSurrogate outcomesBACKGROUND/Median numberSurrogate endpointsPrimary analysisCardiovascular interventionsCardiovascular medicineTrialsEndpointClinical interpretationOutcomesMarkersIntervention
2019
Noninferiority Designed Cardiovascular Trials in Highest-Impact Journals
Bikdeli B, Welsh JW, Akram Y, Punnanithinont N, Lee I, Desai NR, Kaul S, Stone G, Ross JS, Krumholz HM. Noninferiority Designed Cardiovascular Trials in Highest-Impact Journals. Circulation 2019, 140: 379-389. PMID: 31177811, PMCID: PMC8416048, DOI: 10.1161/circulationaha.119.040214.Peer-Reviewed Original ResearchConceptsNoninferiority marginNoninferiority trialCardiovascular trialsAllocation concealmentLower riskOpen labelHazard ratioRelative riskMethodological qualityProportion of trialsIndependent reviewersRisk differenceNew England JournalNoninferiorityHigh-impact journalsNew interventionsTrialsCohortDiscrepant resultsProtocol analysisTime trendsRiskTreatInterventionFactors
2017
Perspectives from NHLBI Global Health Think Tank Meeting for Late Stage (T4) Translation Research
Engelgau MM, Peprah E, Sampson UKA, Mishoe H, Benjamin IJ, Douglas PS, Hochman JS, Ridker PM, Brandes N, Checkley W, El-Saharty S, Ezzati M, Hennis A, Jiang L, Krumholz HM, Lamourelle G, Makani J, Narayan KMV, Ohene-Frempong K, Straus SE, Stuckler D, Chambers DA, Belis D, Bennett GC, Boyington JE, Creazzo TL, de Jesus JM, Krishnamurti C, Lowden MR, Punturieri A, Shero ST, Young NS, Zou S, Mensah GA. Perspectives from NHLBI Global Health Think Tank Meeting for Late Stage (T4) Translation Research. Global Heart 2017, 12: 341-348. PMID: 27452772, DOI: 10.1016/j.gheart.2016.03.640.Peer-Reviewed Original ResearchConceptsNational HeartDisease burdenNoncommunicable disease burdenHealth delivery modelsGlobal health researchMiddle-income countriesBlood InstituteGlobal health disparitiesThink Tank meetingHealth disparitiesEffective interventionsCompelling scientific questionsLungTank meetingHealth researchSustainable interventionsHeartThree-quartersDelivery modelInterventionBurdenImplementation strategiesResearch capacityMajor themesLater stagesTwo Decades of Cardiovascular Trials With Primary Surrogate Endpoints: 1990–2011
Bikdeli B, Punnanithinont N, Akram Y, Lee I, Desai NR, Ross JS, Krumholz HM. Two Decades of Cardiovascular Trials With Primary Surrogate Endpoints: 1990–2011. Journal Of The American Heart Association 2017, 6: e005285. PMID: 28325713, PMCID: PMC5524035, DOI: 10.1161/jaha.116.005285.Peer-Reviewed Original ResearchConceptsClinical outcome trialsOutcome trialsEndpoint trialsPrimary endpointCardiovascular trialsClinical outcome studiesClinical outcomesSurrogate markerPatient's perspectiveSurrogate endpointsOutcome studiesNew England JournalSample cohortTrial resultsTrialsSurrogate trialsEndpointPositive resultsAmerican MedicalInterventionHigh-impact journalsCohort
2016
2015 ACC/AHA/SCAI focused update on primary percutaneous coronary intervention for patients with ST‐elevation myocardial Infarction: An update of the 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention and the 2013 ACCF/AHA guideline for the management of ST‐elevation myocardial infarction: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Society for Cardiovascular Angiography and Interventions
Cardiology E, COMMITTEE P, Levine GN, Bates ER, Blankenship JC, Bailey SR, Bittl JA, Cercek B, Chambers CE, Ellis SG, Guyton RA, Hollenberg SM, Khot UN, Lange RA, Mauri L, Mehran R, Moussa ID, Mukherjee D, Ting HH, COMMITTEE S, O'Gara PT, Kushner FG, Ascheim DD, Brindis RG, Casey DE, Chung MK, de Lemos JA, Diercks DB, Fang JC, Franklin BA, Granger CB, Krumholz HM, Linderbaum JA, Morrow DA, Newby L, Ornato JP, Ou N, Radford MJ, Tamis‐Holland J, Tommaso CL, Tracy CM, Woo Y, Zhao DX, MEMBERS A, Halperin JL, Levine GN, Anderson JL, Albert NM, Al‐Khatib S, Birtcher KK, Bozkurt B, Brindis RG, Cigarroa JE, Curtis LH, Fleisher LA, Gentile F, Gidding S, Hlatky MA, Ikonomidis J, Joglar J, Kovacs RJ, Ohman E, Pressler SJ, Sellke FW, Shen W, Wijeysundera DN. 2015 ACC/AHA/SCAI focused update on primary percutaneous coronary intervention for patients with ST‐elevation myocardial Infarction: An update of the 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention and the 2013 ACCF/AHA guideline for the management of ST‐elevation myocardial infarction: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. Catheterization And Cardiovascular Interventions 2016, 87: 1001-1019. PMID: 26489034, DOI: 10.1002/ccd.26325.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionPercutaneous coronary interventionCoronary interventionMyocardial infarctionCardiology/American Heart Association Task ForceACCF/AHA/SCAI guidelinesAmerican Heart Association Task ForcePrimary percutaneous coronary interventionACCF/AHA guidelinesClinical practice guidelinesAHA guidelinesPractice guidelinesCardiovascular AngiographyAmerican CollegeInfarctionInterventionTask ForceGuidelinesAngiographyPatients
2015
2015 ACC/AHA/SCAI Focused Update on Primary Percutaneous Coronary Intervention for Patients With ST-Elevation Myocardial Infarction An Update of the 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention and the 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction
Levine GN, Bates ER, Blankenship JC, Bailey SR, Bittl JA, Cercek B, Chambers CE, Ellis SG, Guyton RA, Hollenberg SM, Khot UN, Lange RA, Mauri L, Mehran R, Moussa ID, Mukherjee D, Ting HH, O’Gara P, Kushner FG, Ascheim DD, Brindis RG, Casey DE, Chung MK, de Lemos JA, Diercks DB, Fang JC, Franklin BA, Granger CB, Krumholz HM, Linderbaum JA, Morrow DA, Newby LK, Ornato JP, Ou N, Radford MJ, Tamis-Holland JE, Tommaso CL, Tracy CM, Woo YJ, Zhao DX. 2015 ACC/AHA/SCAI Focused Update on Primary Percutaneous Coronary Intervention for Patients With ST-Elevation Myocardial Infarction An Update of the 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention and the 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction. Journal Of The American College Of Cardiology 2015, 67: 1235-1250. PMID: 26498666, DOI: 10.1016/j.jacc.2015.10.005.Peer-Reviewed Original Research
2013
Determinants of fluoroscopy time for invasive coronary angiography and percutaneous coronary intervention: Insights from the NCDR®
Fazel R, Curtis J, Wang Y, Einstein AJ, Smith‐Bindman R, Tsai TT, Chen J, Shah ND, Krumholz HM, Nallamothu BK. Determinants of fluoroscopy time for invasive coronary angiography and percutaneous coronary intervention: Insights from the NCDR®. Catheterization And Cardiovascular Interventions 2013, 82: 1091-1105. PMID: 23703793, DOI: 10.1002/ccd.24996.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionInvasive coronary angiographyHospital-level factorsFluoroscopy timePrior CABGCoronary interventionPrior coronary artery bypassRadiation exposureCoronary artery bypassNumerous clinical scenariosArtery bypassCathPCI RegistryPatient characteristicsCoronary angiographyPCI proceduresModifiable determinantsPatientsClinical scenariosModifiable sourceProcedure complexityCABGMinutesInterventionExposureWide variationComparison of Clinical Interpretation With Visual Assessment and Quantitative Coronary Angiography in Patients Undergoing Percutaneous Coronary Intervention in Contemporary Practice
Nallamothu BK, Spertus JA, Lansky AJ, Cohen DJ, Jones PG, Kureshi F, Dehmer GJ, Drozda JP, Walsh MN, Brush JE, Koenig GC, Waites TF, Gantt DS, Kichura G, Chazal RA, O’Brien P, Valentine CM, Rumsfeld JS, Reiber JH, Elmore JG, Krumholz RA, Weaver WD, Krumholz HM. Comparison of Clinical Interpretation With Visual Assessment and Quantitative Coronary Angiography in Patients Undergoing Percutaneous Coronary Intervention in Contemporary Practice. Circulation 2013, 127: 1793-1800. PMID: 23470859, PMCID: PMC3908681, DOI: 10.1161/circulationaha.113.001952.Peer-Reviewed Original ResearchConceptsQuantitative coronary angiographyPercent diameter stenosisPercutaneous coronary interventionDiameter stenosisCoronary interventionCoronary angiographyCoronary lesionsClinical interpretationAngiographic interpretationStenosis severityHigher percent diameter stenosisMedian percent diameter stenosisElective percutaneous coronary interventionMean differenceCoronary stenosis severityIntermediate lesionsUS hospitalsStenosisLesionsAngiographyPatientsInterventionSeverityVisual assessmentSuch findings
2011
National Performance on Door-In to Door-Out Time Among Patients Transferred for Primary Percutaneous Coronary Intervention
Herrin J, Miller LE, Turkmani DF, Nsa W, Drye EE, Bernheim SM, Ling SM, Rapp MT, Han LF, Bratzler DW, Bradley EH, Nallamothu BK, Ting HH, Krumholz HM. National Performance on Door-In to Door-Out Time Among Patients Transferred for Primary Percutaneous Coronary Intervention. JAMA Internal Medicine 2011, 171: 1879-1886. PMID: 22123793, PMCID: PMC4312661, DOI: 10.1001/archinternmed.2011.481.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionDIDO timeCoronary interventionST-segment elevation acute myocardial infarctionMixed-effects multivariable modelElevation acute myocardial infarctionPrimary percutaneous coronary interventionMedian DIDO timeAcute myocardial infarctionFibrinolytic therapyPatient characteristicsMultivariable analysisEmergency departmentMyocardial infarctionHospital characteristicsMultivariable modelPatientsRural hospitalsHospitalMedicaid ServicesAge categoriesInterventionAfrican AmericansMinutesTreatment timeImprovements in Door-to-Balloon Time in the United States, 2005 to 2010
Krumholz HM, Herrin J, Miller LE, Drye EE, Ling SM, Han LF, Rapp MT, Bradley EH, Nallamothu BK, Nsa W, Bratzler DW, Curtis JP. Improvements in Door-to-Balloon Time in the United States, 2005 to 2010. Circulation 2011, 124: 1038-1045. PMID: 21859971, PMCID: PMC3598634, DOI: 10.1161/circulationaha.111.044107.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPercutaneous coronary interventionBalloon timeCoronary interventionMedian timeST-segment elevation myocardial infarctionHigher median timeCharacteristics of patientsPercentage of patientsTimeliness of treatmentYears of ageRegistry studyMyocardial infarctionInpatient measuresPatientsHospital groupMedicaid ServicesCalendar yearInterventionMinutesMedianGroupYearsPercentageInfarction
2009
Association of Door-to-Balloon Time and Mortality in Patients ≥65 Years With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Rathore SS, Curtis JP, Nallamothu BK, Wang Y, Foody JM, Kosiborod M, Masoudi FA, Havranek EP, Krumholz HM. Association of Door-to-Balloon Time and Mortality in Patients ≥65 Years With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. The American Journal Of Cardiology 2009, 104: 1198-1203. PMID: 19840562, PMCID: PMC2790921, DOI: 10.1016/j.amjcard.2009.06.034.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIST-elevation myocardial infarctionPercutaneous coronary interventionBalloon timeMyocardial infarctionCoronary interventionAssociation of doorMinutes of admissionSecond-degree fractional polynomialsLogistic regression analysisFractional polynomial modelsMultivariable adjustmentLonger doorMedian doorCurrent guidelinesPatientsMortalityInfarctionRegression analysisFractional polynomialsAssociationInterventionMinutesTreatment
2007
Randomized Trial of Telemonitoring to Improve Heart Failure Outcomes (Tele-HF): Study Design
Chaudhry SI, Barton B, Mattera J, Spertus J, Krumholz HM. Randomized Trial of Telemonitoring to Improve Heart Failure Outcomes (Tele-HF): Study Design. Journal Of Cardiac Failure 2007, 13: 709-714. PMID: 17996818, PMCID: PMC2702538, DOI: 10.1016/j.cardfail.2007.06.720.Peer-Reviewed Case Reports and Technical NotesConceptsHeart failure outcomesHeart failureClinical statusFailure outcomesDecompensated heart failureHeart failure decompensationCare of patientsPrimary care practicesSelf-reported weightUsual careHospital readmissionDaily symptomsRandomized trialsGeneral cardiologyPatient participationHealth behaviorsCare practicesPatientsFrequent monitoringFavorable effectInterventionOutcomesSymptomsTrialsCare
2006
Driving Times and Distances to Hospitals With Percutaneous Coronary Intervention in the United States
Nallamothu BK, Bates ER, Wang Y, Bradley EH, Krumholz HM. Driving Times and Distances to Hospitals With Percutaneous Coronary Intervention in the United States. Circulation 2006, 113: 1189-1195. PMID: 16520425, DOI: 10.1161/circulationaha.105.596346.Peer-Reviewed Original ResearchConceptsNon-PCI hospitalsPercutaneous coronary interventionST-elevation myocardial infarctionPCI hospitalsAdult populationCoronary interventionPrehospital triage protocolsAdults 18 yearsCross-sectional studyAmerican Hospital Association Annual SurveyHospital-level dataMedian timeMyocardial infarctionDirect referralTriage protocolHospitalTimely accessPatientsUnited StatesMinutesCensus tract-level dataInterventionTract-level dataTransport timePopulation
2005
From Adversary to Partner: Have Quality Improvement Organizations Made the Transition?
Bradley EH, Carlson MD, Gallo WT, Scinto J, Campbell MK, Krumholz HM. From Adversary to Partner: Have Quality Improvement Organizations Made the Transition? Health Services Research 2005, 40: 459-476. PMID: 15762902, PMCID: PMC1361151, DOI: 10.1111/j.1475-6773.2005.0y368.x.Peer-Reviewed Original ResearchMeSH KeywordsAttitude of Health PersonnelBenchmarkingCenters for Medicare and Medicaid Services, U.S.Cross-Sectional StudiesHealth PromotionHospital AdministratorsHospitalsHumansMyocardial InfarctionOrganizational InnovationPhysician ExecutivesProfessional Review OrganizationsQuality Indicators, Health CareTotal Quality ManagementUnited StatesConceptsQuality Improvement OrganizationQuality of careAcute myocardial infarctionImprovement organizationsPeer review organizationsMyocardial infarctionHospital performance dataTarget physiciansNational random sampleSpecific interventionsHospitalHospital administrationQuality improvement directorsInterventionCareReview organizationsPhysiciansRandom sampleAdministrationOne-quarterManagement directorsInfarctionEducational materialsPatientsRespondents
2004
Clinical trial of an educational intervention to achieve recommended cholesterol levels in patients with coronary artery disease
Lichtman JH, Amatruda J, Yaari S, Cheng S, Smith GL, Mattera JA, Roumanis SA, Wang Y, Radford MJ, Krumholz HM. Clinical trial of an educational intervention to achieve recommended cholesterol levels in patients with coronary artery disease. American Heart Journal 2004, 147: 522-528. PMID: 14999204, DOI: 10.1016/j.ahj.2003.06.003.Peer-Reviewed Original ResearchConceptsLDL cholesterol target levelsCholesterol target levelsProportion of patientsCoronary artery diseaseUsual care groupArtery diseaseLevels 1 yearCholesterol managementCare groupEducational interventionPatient knowledgeLow-density lipoprotein cholesterol (LDL-C) target levelsTarget levelCholesterol knowledgeUsual careClinical characteristicsSecondary outcomesPrimary outcomeCholesterol levelsClinical trialsIntervention groupPatientsHospitalizationDiseaseIntervention
2003
What Are Hospitals Doing to Increase Beta-Blocker Use?
Bradley EH, Holmboe ES, Wang Y, Herrin J, Frederick PD, Mattera JA, Roumanis SA, Radford MJ, Krumholz HM. What Are Hospitals Doing to Increase Beta-Blocker Use? The Joint Commission Journal On Quality And Patient Safety 2003, 29: 409-415. PMID: 12953605, DOI: 10.1016/s1549-3741(03)29049-3.Peer-Reviewed Original ResearchConceptsBeta-blocker useQuality improvement interventionsMyocardial infarctionCare coordinatorsClinical pathwayImprovement interventionsAcute myocardial infarctionCross-sectional analysisQuality improvement staffQuality improvement effortsNational registryMedian numberHospitalTelephone surveyInfarctionReminder FormInterventionImprovement effortsRegistryPrevalencePathwayPhysicians
2002
Randomized trial of an education and support intervention to preventreadmission of patients with heart failure
Krumholz HM, Amatruda J, Smith GL, Mattera JA, Roumanis SA, Radford MJ, Crombie P, Vaccarino V. Randomized trial of an education and support intervention to preventreadmission of patients with heart failure. Journal Of The American College Of Cardiology 2002, 39: 83-89. PMID: 11755291, DOI: 10.1016/s0735-1097(01)01699-0.Peer-Reviewed Original ResearchConceptsHeart failureSupport interventionsIntervention groupControl groupHospital readmission costsOne-year readmissionRate of readmissionAdverse clinical outcomesCost of careDisease management programsReadmission costsClinical outcomesHospital costsReadmissionLower riskPatientsOne-yearDemographic characteristicsInterventionTrialsGroupFormal educationTotal numberMedical componentsFailure
1999
Cost-Effectiveness Analysis and the Treatment of Acute Coronary Syndromes
Krumholz H. Cost-Effectiveness Analysis and the Treatment of Acute Coronary Syndromes. Contemporary Cardiology 1999, 601-610. DOI: 10.1007/978-1-59259-731-4_25.Peer-Reviewed Original ResearchAcute coronary syndromeCoronary heart diseaseHealth care resourcesCost-effectiveness analysisHealth care systemHealth care expendituresCoronary syndromeCardiac eventsPharmacologic interventionsHeart diseaseEfficacious therapyCardiovascular diseaseCare resourcesNew interventionsCare expendituresCare systemHealth benefitsInterventionCare organizationsDiseaseTreatmentStandard practicePatientsHospitalSyndrome
1993
Cost-effectiveness of a smoking cessation program after myocardial infarction
Krumholz H, Cohen B, Tsevat J, Pasternak R, Weinstein M. Cost-effectiveness of a smoking cessation program after myocardial infarction. Journal Of The American College Of Cardiology 1993, 22: 1697-1702. PMID: 8227841, DOI: 10.1016/0735-1097(93)90598-u.Peer-Reviewed Original ResearchConceptsSmoking cessation programAcute myocardial infarctionNurse-managed smoking cessation programCessation programsMyocardial infarctionYears of lifeBeta-adrenergic antagonist therapyLife expectancyOne-way sensitivity analysesTwo-way sensitivity analysesCost-effective interventionHealth care resourcesAntagonist therapySmoking ratesInfarctionCare resourcesSmokersInterventionProgram costsYearsExpectancyTherapyLife