2021
Administrative Claims Measure for Profiling Hospital Performance Based on 90-Day All-Cause Mortality Following Coronary Artery Bypass Graft Surgery
Mori M, Nasir K, Bao H, Jimenez A, Legore SS, Wang Y, Grady J, Lama SD, Brandi N, Lin Z, Kurlansky P, Geirsson A, Bernheim SM, Krumholz HM, Suter LG. Administrative Claims Measure for Profiling Hospital Performance Based on 90-Day All-Cause Mortality Following Coronary Artery Bypass Graft Surgery. Circulation Cardiovascular Quality And Outcomes 2021, 14: e006644. PMID: 33535776, DOI: 10.1161/circoutcomes.120.006644.Peer-Reviewed Original ResearchConceptsRisk-standardized mortality ratesCoronary artery bypass graft surgeryArtery bypass graft surgeryBypass graft surgeryMortality rateGraft surgeryC-statisticMedicaid ServicesAdministrative Claims MeasureCause mortality ratesMortality measuresUnadjusted mortality ratesProfiling Hospital PerformanceHierarchical logistic regression modelsAlternate payment modelsHospital performanceLogistic regression modelsCABG recoveryPayment modelsCABG surgeryCause mortalityCABG proceduresDays postsurgeryHospital levelSurgery
2019
The relationship between off-hours admissions for primary percutaneous coronary intervention, door-to-balloon time and mortality for patients with ST-elevation myocardial infarction in England: a registry-based prospective national cohort study
Jayawardana S, Salas-Vega S, Cornehl F, Krumholz HM, Mossialos E. The relationship between off-hours admissions for primary percutaneous coronary intervention, door-to-balloon time and mortality for patients with ST-elevation myocardial infarction in England: a registry-based prospective national cohort study. BMJ Quality & Safety 2019, 29: 541-549. PMID: 31831635, PMCID: PMC7362773, DOI: 10.1136/bmjqs-2019-010067.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionOff-hours admissionPercutaneous coronary interventionDTB timeCoronary interventionBalloon timeST-elevation myocardial infarction (STEMI) patientsElevation myocardial infarction patientsProspective national cohort studyST-elevation myocardial infarctionCent of admissionsMedian DTB timeOff-hour effectPatient risk factorsProspective observational studyRecords of patientsPrimary outcome measureNational cohort studyTimeliness of careMyocardial infarction patientsHierarchical logistic regression modelsLogistic regression modelsHospital mortalityCohort studySecondary outcomesTraditional Chinese Medicine Use in the Treatment of Acute Heart Failure in Western Medicine Hospitals in China: Analysis From the China PEACE Retrospective Heart Failure Study
Yu Y, Spatz ES, Tan Q, Liu S, Lu Y, Masoudi FA, Schulz WL, Krumholz HM, Li J, Group T. Traditional Chinese Medicine Use in the Treatment of Acute Heart Failure in Western Medicine Hospitals in China: Analysis From the China PEACE Retrospective Heart Failure Study. Journal Of The American Heart Association 2019, 8: e012776. PMID: 31364457, PMCID: PMC6761625, DOI: 10.1161/jaha.119.012776.Peer-Reviewed Original ResearchConceptsTraditional Chinese medicineAcute heart failureHeart failureEvidence-based therapiesWestern Medicine HospitalTCM useMedicine HospitalEvidence-based therapy useTraditional Chinese medicine useChinese medicine useCoronary artery diseaseHeart Failure StudyHierarchical logistic regression modelsLogistic regression modelsSalvia miltiorrhizaRandom sampleHospital bleedingPatient's bleedingPatient characteristicsArtery diseaseTherapy useMedicine useHospital characteristicsRetrospective analysisHospital use
2018
Emergency Department Volume and Outcomes for Patients After Chest Pain Assessment
Ko DT, Dattani ND, Austin PC, Schull MJ, Ross JS, Wijeysundera HC, Tu JV, Eberg M, Koh M, Krumholz HM. Emergency Department Volume and Outcomes for Patients After Chest Pain Assessment. Circulation Cardiovascular Quality And Outcomes 2018, 11: e004683. PMID: 30354285, DOI: 10.1161/circoutcomes.118.004683.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeChest painHigh-volume EDsCoronary syndromeED volumeVolume thresholdCardiac medication useChest pain assessmentLower adverse outcomesEmergency department visitsAdjusted odds ratioPopulation-based dataProcess of carePotential confounding variablesHigher ED volumesHierarchical logistic regression modelsLogistic regression modelsEmergency department volumeCause deathCardiac testingComposite outcomeDepartment visitsDiabetes mellitusMedication usePrimary outcome
2014
Hospital Variation in Noninvasive Positive Pressure Ventilation for Acute Decompensated Heart Failure
Kulkarni VT, Kim N, Dai Y, Dharmarajan K, Safavi KC, Bikdeli B, Lindenauer PK, Testani J, Dries DL, Krumholz HM. Hospital Variation in Noninvasive Positive Pressure Ventilation for Acute Decompensated Heart Failure. Circulation Heart Failure 2014, 7: 427-433. PMID: 24633829, PMCID: PMC4386575, DOI: 10.1161/circheartfailure.113.000698.Peer-Reviewed Original ResearchConceptsAcute decompensated heart failureNoninvasive positive pressure ventilationDecompensated heart failureRisk-standardized mortality ratesPositive pressure ventilationHeart failureIntubation rateMortality ratePressure ventilationUse of NPPVHospital risk-standardized mortality ratesHigher intubation rateHospital practice patternsHospital-level outcomesCross-sectional studyHierarchical logistic regression modelsLogistic regression modelsNIPPV useHospital variationSuch hospitalizationsPractice patternsHospitalizationHospitalQuartileBottom quartile
2013
Regional Density of Cardiologists and Rates of Mortality for Acute Myocardial Infarction and Heart Failure
Kulkarni VT, Ross JS, Wang Y, Nallamothu BK, Spertus JA, Normand SL, Masoudi FA, Krumholz HM. Regional Density of Cardiologists and Rates of Mortality for Acute Myocardial Infarction and Heart Failure. Circulation Cardiovascular Quality And Outcomes 2013, 6: 352-359. PMID: 23680965, PMCID: PMC5323047, DOI: 10.1161/circoutcomes.113.000214.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiologyCohort StudiesFemaleHealth Services AccessibilityHealth Services Needs and DemandHealthcare DisparitiesHeart FailureHospitalizationHumansLinear ModelsLogistic ModelsMaleMedicareMyocardial InfarctionOdds RatioPhysiciansPneumoniaPrognosisResidence CharacteristicsRisk AssessmentRisk FactorsTime FactorsUnited StatesWorkforceConceptsAcute myocardial infarctionHeart failureHospital referral regionsMortality riskLowest quintileMyocardial infarctionReferral regionsMedicare administrative claims dataCharacteristics of patientsRisk of deathAdministrative claims dataHierarchical logistic regression modelsLogistic regression modelsRate of mortalityRegional densityHighest quintileNumber of cardiologistsWorse outcomesClaims dataPatientsPneumoniaCardiologistsHospitalizationAdmissionQuintile
2012
Hospital Patterns of Use of Positive Inotropic Agents in Patients With Heart Failure
Partovian C, Gleim SR, Mody PS, Li SX, Wang H, Strait KM, Allen LA, Lagu T, Normand SL, Krumholz HM. Hospital Patterns of Use of Positive Inotropic Agents in Patients With Heart Failure. Journal Of The American College Of Cardiology 2012, 60: 1402-1409. PMID: 22981548, PMCID: PMC3636773, DOI: 10.1016/j.jacc.2012.07.011.Peer-Reviewed Original ResearchConceptsPositive inotropic agentsRisk-standardized ratesInotropic agentsHeart failureInotrope useHospital patternsMortality rateRisk-standardized mortality ratesHospital mortality rateHeart failure patientsLittle clinical evidenceLength of stayPatient case mixHierarchical logistic regression modelsLogistic regression modelsIntraclass correlation coefficientFailure patientsHospital variationClinical evidenceInterhospital variationClinical guidelinesIndividual hospital effectsHospital ratesHospital effectsPatterns of useDevelopment of 2 Registry-Based Risk Models Suitable for Characterizing Hospital Performance on 30-Day All-Cause Mortality Rates Among Patients Undergoing Percutaneous Coronary Intervention
Curtis JP, Geary LL, Wang Y, Chen J, Drye EE, Grosso LM, Spertus JA, Rumsfeld JS, Weintraub WS, Masoudi FA, Brindis RG, Krumholz HM. Development of 2 Registry-Based Risk Models Suitable for Characterizing Hospital Performance on 30-Day All-Cause Mortality Rates Among Patients Undergoing Percutaneous Coronary Intervention. Circulation Cardiovascular Quality And Outcomes 2012, 5: 628-637. PMID: 22949491, DOI: 10.1161/circoutcomes.111.964569.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overAngina PectorisChi-Square DistributionComorbidityFemaleHeart DiseasesHospital MortalityHospitalsHumansLogistic ModelsMaleMyocardial InfarctionOdds RatioOutcome and Process Assessment, Health CarePercutaneous Coronary InterventionQuality Indicators, Health CareRegistriesRisk AssessmentRisk FactorsShock, CardiogenicTime FactorsTreatment OutcomeUnited StatesConceptsST-segment elevation myocardial infarctionPercutaneous coronary interventionRisk-standardized mortality ratesElevation myocardial infarctionPatient mortality ratesMyocardial infarctionMortality rateCardiogenic shockCoronary interventionDerivation cohortHospital risk-standardized mortality ratesCause mortality ratesAdministrative claims dataQuality of careHierarchical logistic regression modelsNational Quality ForumLogistic regression modelsObserved mortality rateCathPCI RegistryNational HospitalClaims dataInfarctionPatientsQuality ForumFinal model
2011
Use and Effectiveness of Intra-Aortic Balloon Pumps Among Patients Undergoing High Risk Percutaneous Coronary Intervention
Curtis JP, Rathore SS, Wang Y, Chen J, Nallamothu BK, Krumholz HM. Use and Effectiveness of Intra-Aortic Balloon Pumps Among Patients Undergoing High Risk Percutaneous Coronary Intervention. Circulation Cardiovascular Quality And Outcomes 2011, 5: 21-30. PMID: 22147887, PMCID: PMC3801197, DOI: 10.1161/circoutcomes.110.960385.Peer-Reviewed Original ResearchConceptsHigh-risk percutaneous coronary interventionIntra-aortic balloon pumpPercutaneous coronary interventionHospital quartilesHospital mortalityIABP useCoronary interventionBalloon pumpHospital characteristicsST-segment elevation myocardial infarctionDepressed left ventricular functionHigh-risk PCI patientsSegment elevation myocardial infarctionElevation myocardial infarctionLeft ventricular functionHierarchical logistic regression modelsLogistic regression modelsIABP usageCardiogenic shockPCI patientsCathPCI RegistryHemodynamic supportVentricular functionHospital variationMultivariable analysis
2010
Is Same-Hospital Readmission Rate a Good Surrogate for All-Hospital Readmission Rate?
Nasir K, Lin Z, Bueno H, Normand SL, Drye EE, Keenan PS, Krumholz HM. Is Same-Hospital Readmission Rate a Good Surrogate for All-Hospital Readmission Rate? Medical Care 2010, 48: 477-481. PMID: 20393366, DOI: 10.1097/mlr.0b013e3181d5fb24.Peer-Reviewed Original ResearchConceptsRisk-standardized readmission ratesHospital readmission ratesSame-hospital readmissionsSame-hospital readmission ratesDays of dischargeReadmission ratesHeart failureUS acute care hospitalsThirty-day readmissionStandard Analytic FilesAcute care hospitalsHierarchical logistic regression modelsLogistic regression modelsCause readmissionHF readmissionIndex hospitalizationCare hospitalHospital readmissionAnalytic FilesMedicare inpatientReadmissionStudy populationHospital measuresReadmission measuresHospitalizationHospital Volume and 30-Day Mortality for Three Common Medical Conditions
Ross JS, Normand SL, Wang Y, Ko DT, Chen J, Drye EE, Keenan PS, Lichtman JH, Bueno H, Schreiner GC, Krumholz HM. Hospital Volume and 30-Day Mortality for Three Common Medical Conditions. New England Journal Of Medicine 2010, 362: 1110-1118. PMID: 20335587, PMCID: PMC2880468, DOI: 10.1056/nejmsa0907130.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHospital volumeHeart failureMyocardial infarctionVolume thresholdRisk factorsAnnual hospital volumeHigh-volume hospitalsPatient risk factorsOdds of deathCommon medical conditionsAcute care hospitalsMedicare administrative claimsHierarchical logistic regression modelsCross-sectional analysisLogistic regression modelsCare hospitalHospital characteristicsReduced oddsMedical conditionsAdministrative claimsInfarctionPatientsPneumoniaService beneficiaries
2009
Association of Physician Certification and Outcomes Among Patients Receiving an Implantable Cardioverter-Defibrillator
Curtis JP, Luebbert JJ, Wang Y, Rathore SS, Chen J, Heidenreich PA, Hammill SC, Lampert RI, Krumholz HM. Association of Physician Certification and Outcomes Among Patients Receiving an Implantable Cardioverter-Defibrillator. JAMA 2009, 301: 1661-1670. PMID: 19383957, PMCID: PMC2805129, DOI: 10.1001/jama.2009.547.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac ElectrophysiologyCertificationClinical CompetenceDefibrillators, ImplantableFemaleHumansIntraoperative ComplicationsLogistic ModelsMaleMedicineMiddle AgedOutcome and Process Assessment, Health CarePhysiciansPostoperative ComplicationsProsthesis ImplantationRegistriesRetrospective StudiesSpecializationTreatment OutcomeUnited StatesConceptsCRT-D devicesThoracic surgeonsICD implantationPhysician certificationImplantable cardioverter-defibrillator (ICD) proceduresRetrospective cohort studyCardiac resynchronization therapyPatients meeting criteriaRisk of complicationsProcedural complication rateImplantable cardioverter defibrillatorHierarchical logistic regression modelsLogistic regression modelsCohort studyComplication rateICD RegistryResynchronization therapyProcedural complicationsIndependent associationPhysician specialtyCardioverter defibrillatorHigh riskPatientsMeeting criteriaNonelectrophysiologists
2008
An Administrative Claims Measure Suitable for Profiling Hospital Performance on the Basis of 30-Day All-Cause Readmission Rates Among Patients With Heart Failure
Keenan PS, Normand SL, Lin Z, Drye EE, Bhat KR, Ross JS, Schuur JD, Stauffer BD, Bernheim SM, Epstein AJ, Wang Y, Herrin J, Chen J, Federer JJ, Mattera JA, Wang Y, Krumholz HM. An Administrative Claims Measure Suitable for Profiling Hospital Performance on the Basis of 30-Day All-Cause Readmission Rates Among Patients With Heart Failure. Circulation Cardiovascular Quality And Outcomes 2008, 1: 29-37. PMID: 20031785, DOI: 10.1161/circoutcomes.108.802686.Peer-Reviewed Original ResearchConceptsRisk-standardized readmission ratesCause readmission rateReadmission ratesHeart failureHospital-level readmission ratesAdjusted readmission ratesAdministrative Claims MeasureUnadjusted readmission ratesHeart failure patientsHospital risk-standardized readmission ratesMedical record dataProfiling Hospital PerformanceHierarchical logistic regression modelsUse of MedicareMedical record modelNational Quality ForumLogistic regression modelsCause readmissionClaims-based modelsHospital dischargeFailure patientsC-statisticPreventable eventsPatientsQuality Forum
2006
Socioeconomic status, treatment, and outcomes among elderly patients hospitalized with heart failure: Findings from the National Heart Failure Project
Rathore SS, Masoudi FA, Wang Y, Curtis JP, Foody JM, Havranek EP, Krumholz HM. Socioeconomic status, treatment, and outcomes among elderly patients hospitalized with heart failure: Findings from the National Heart Failure Project. American Heart Journal 2006, 152: 371-378. PMID: 16875925, PMCID: PMC2790269, DOI: 10.1016/j.ahj.2005.12.002.Peer-Reviewed Original ResearchConceptsLeft ventricular systolic function assessmentHigh SES patientsVentricular systolic function assessmentHeart failureSES patientsSystolic function assessmentYear of dischargeQuality of careSocioeconomic statusMultivariable adjustmentFunction assessmentEnzyme inhibitorsNational Heart Failure ProjectHeart Failure ProjectPrescription of angiotensinLow SES patientsPatients' socioeconomic statusAssociation of SESYear of admissionMedical record dataHierarchical logistic regression modelsLow socioeconomic statusLogistic regression modelsPatient sElderly patients
2005
Sex, quality of care, and outcomes of elderly patients hospitalized with heart failure: Findings from the National Heart Failure Project
Rathore SS, Foody JM, Wang Y, Herrin J, Masoudi FA, Havranek EP, Ordin DL, Krumholz HM. Sex, quality of care, and outcomes of elderly patients hospitalized with heart failure: Findings from the National Heart Failure Project. American Heart Journal 2005, 149: 121-128. PMID: 15660043, PMCID: PMC2790278, DOI: 10.1016/j.ahj.2004.06.008.Peer-Reviewed Original ResearchConceptsAngiotensin receptor blockersNational Heart Failure ProjectLeft ventricular systolic functionQuality of careACE inhibitor prescriptionHeart Failure ProjectService Medicare patientsHeart failureInhibitor prescriptionMedicare patientsMultivariable hierarchical logistic regression modelsLower crude ratesPrescription of angiotensinLeft ventricular dysfunctionVentricular systolic functionYear of admissionHierarchical logistic regression modelsLower mortality rateLogistic regression modelsSex differencesLow overall rateMultivariable adjustmentVentricular dysfunctionElderly patientsReceptor blockers
2004
Predictors of cardiologist care for older patients hospitalized for heart failure
Foody JM, Rathore SS, Wang Y, Herrin J, Masoudi FA, Havranek EP, Radford MJ, Krumholz HM. Predictors of cardiologist care for older patients hospitalized for heart failure. American Heart Journal 2004, 147: 66-73. PMID: 14691421, DOI: 10.1016/j.ahj.2003.07.005.Peer-Reviewed Original ResearchConceptsHeart failureSpecialty careOlder patientsMultivariable hierarchical logistic regression modelsCoronary Artery Bypass GraftingChronic obstructive pulmonary diseasePercutaneous transluminal coronary angioplastyArtery Bypass GraftingHeart failure careObstructive pulmonary diseaseTransluminal coronary angioplastyHierarchical logistic regression modelsLogistic regression modelsCardiologist careBypass GraftingHospital factorsPatient characteristicsCardiology consultCoronary angioplastyCoronary diseasePulmonary diseaseClinical presentationCardiology carePatient raceMedicare patients
2003
Regional variation in the treatment and outcomes of myocardial infarction: investigating New England’s advantage
Krumholz HM, Chen J, Rathore SS, Wang Y, Radford MJ. Regional variation in the treatment and outcomes of myocardial infarction: investigating New England’s advantage. American Heart Journal 2003, 146: 242-249. PMID: 12891191, DOI: 10.1016/s0002-8703(03)00237-0.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAngioplasty, Balloon, CoronaryAspirinCoronary Artery BypassFemaleFibrinolytic AgentsHospitalizationHumansLogistic ModelsMaleMyocardial InfarctionNew EnglandOutcome Assessment, Health CarePractice Patterns, Physicians'Quality of Health CareThrombolytic TherapyUnited StatesConceptsPractice patternsMortality rateReperfusion therapyBetter short-term outcomesMedical therapy useShort-term outcomesQuality of careHierarchical logistic regression modelsMyocardial infarction treatmentLogistic regression modelsTherapy useMyocardial infarctionHospital characteristicsPhysician characteristicsProvider characteristicsBetter outcomesInfarction treatmentPatientsMI treatmentRegional variationLow useRegional differencesAspirinHospitalTherapy