2012
Role of Intensive Glucose Control in Development of Renal End Points in Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis
Coca SG, Ismail-Beigi F, Haq N, Krumholz HM, Parikh CR. Role of Intensive Glucose Control in Development of Renal End Points in Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis. JAMA Internal Medicine 2012, 172: 761-769. PMID: 22636820, PMCID: PMC3688081, DOI: 10.1001/archinternmed.2011.2230.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood GlucoseDiabetes Mellitus, Type 2Diabetic NephropathiesDisease ProgressionFemaleGlycated HemoglobinHumansHypoglycemic AgentsKidney Failure, ChronicKidney Function TestsMaleMiddle AgedMonitoring, PhysiologicPrognosisRandomized Controlled Trials as TopicRenal DialysisRisk AssessmentSeverity of Illness IndexConceptsIntensive glucose controlRenal end pointsSerum creatinine levelsConventional glucose controlGlucose controlType 2 diabetesRenal diseaseCreatinine levelsEnd pointGlycemic controlSystematic reviewType 2 diabetes mellitusAggressive glycemic controlClinical renal outcomesKidney-related outcomesIntensive glycemic controlRenal outcomesCumulative incidenceDiabetes mellitusRandomized trialsConventional therapyLanguage restrictionsMacroalbuminuriaMicroalbuminuriaType 2
2009
Relationship Between Spontaneous and Iatrogenic Hypoglycemia and Mortality in Patients Hospitalized With Acute Myocardial Infarction
Kosiborod M, Inzucchi SE, Goyal A, Krumholz HM, Masoudi FA, Xiao L, Spertus JA. Relationship Between Spontaneous and Iatrogenic Hypoglycemia and Mortality in Patients Hospitalized With Acute Myocardial Infarction. JAMA 2009, 301: 1556-1564. PMID: 19366775, DOI: 10.1001/jama.2009.496.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionInsulin therapyHospital mortalityIatrogenic hypoglycemiaHypoglycemic eventsMyocardial infarctionMortality riskGlucose-lowering therapyRetrospective cohort studySubgroup of patientsHigher mortality riskLogistic regression modelsMore comorbiditiesSubsequent hospitalizationMultivariable adjustmentCohort studyGlucose loweringGlucose controlEpisodic hypoglycemiaMAIN OUTCOMEHypoglycemiaPatientsHealth FactsHigh mortalityTherapyElevated Admission Glucose and Mortality in Elderly Patients Hospitalized With Heart Failure
Kosiborod M, Inzucchi SE, Spertus JA, Wang Y, Masoudi FA, Havranek EP, Krumholz HM. Elevated Admission Glucose and Mortality in Elderly Patients Hospitalized With Heart Failure. Circulation 2009, 119: 1899-1907. PMID: 19332465, DOI: 10.1161/circulationaha.108.821843.Peer-Reviewed Original ResearchConceptsHeart failureAdmission glucoseElderly patientsDiabetes mellitusAdverse outcomesMultivariable Cox regression modelsAdmission glucose levelsElevated admission glucoseAcute myocardial infarctionCox regression modelCause mortalityMultivariable adjustmentEntire cohortGlucose controlMyocardial infarctionCardiovascular conditionsGlucose levelsLarge cohortElevated glucoseRepresentative cohortPatientsSignificant associationMortalityCohortMellitus